Reactome | PEX7 [cytosol]

PEX7 [cytosol]

Stable Identifier

R-HSA-9033107

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Peroxisomal targeting signal 2 receptor, PEX7_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O00628 PEX7

Gene Names

PEX7, PTS2R

Chain

chain:1-323

Reference Genes

BioGPS Gene:5191 O006282

COSMIC (genes):PEX7 PEX7

CTD Gene:5191 PEX7

dbSNP Gene:5191 PEX7

ENSEMBL:ENSG00000112357 PEX7

HGNC:8860 O006282

KEGG:hsa:5191 O006282

Monarch:5191 O006282

NCBI Gene:5191 O006282

OMIM:601757 O006282

UCSC:O00628 O006282

Reference Transcript

RefSeq:NM_000288.4 O006282

Participates

as an output of

PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Homo sapiens)

as a component of

as an input of

PEX7 binds cargo proteins containing PTS2 (Homo sapiens)

Other forms of this molecule

PEX7 [peroxisomal membrane]

Inferred To

pex7 [cytosol] (Danio rerio)

pex7 [cytosol] (Dictyostelium discoideum)

pex7 [cytosol] (Schizosaccharomyces pombe)

PEX7 [cytosol] (Bos taurus)

PEX7 [cytosol] (Canis familiaris)

PEX7 [cytosol] (Gallus gallus)

PEX7 [cytosol] (Saccharomyces cerevisiae)

PEX7 [cytosol] (Sus scrofa)

Pex7 [cytosol] (Drosophila melanogaster)

Pex7 [cytosol] (Mus musculus)

Pex7 [cytosol] (Rattus norvegicus)

Ghost homologue of PEX7 [cytosol] (Caenorhabditis elegans)

Ghost homologue of PEX7 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_000279.1

ENSEMBL

ENSG00000112357, ENST00000541292, ENSP00000315680, ENSP00000441004, ENST00000318471

OpenTargets

ENSG00000112357

GeneCards

PEX7

HPA

ENSG00000112357-PEX7

PRO

O00628

Pharos - Targets

O00628

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H2J4 PDCL3			0.643	4
UniProt:Q92968 PEX13	2	PEX13 [cytosol] (R-HSA-9603795) PEX13 [peroxisomal membrane] (R-HSA-452790)	0.643	4
UniProt:Q13371 PDCL	2	PDCL [cytosol] (R-HSA-6813727) p-S18,S19,S20,S25-PDCL [cytosol] (R-HSA-6814228)	0.643	3
UniProt:P57076 CF298			0.623	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.527	3
UniProt:P78371 CCT2	3	CCT2 [cytosol] (R-HSA-390464) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [extracellular region] (R-HSA-6806220)	0.527	3
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.527	3
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.527	3
UniProt:Q8IYD2 KLD8A			0.527	2
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.527	3
UniProt:O14530 TXND9			0.527	2
UniProt:P50990 CCT8	5	CCT8 [cytosol] (R-HSA-390449) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [azurophil granule lumen] (R-HSA-6799369)	0.527	3
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.527	3
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.527	3
UniProt:Q5I0X4 PEX39			0.527	3
UniProt:Q92526 CCT6B	1	CCT6B [cytosol] (R-HSA-5216201)	0.527	3
UniProt:P61758 VBP1	1	VBP1 [cytosol] (R-HSA-379543)	0.527	2
UniProt:Q9UQ74 PSG8	1	PSG8 [extracellular region] (R-HSA-8870757)	0.527	2
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	3
UniProt:P09110 ACAA1	6	ACAA1(1-26) [peroxisomal matrix] (R-HSA-9033534) ACAA1(1-424) [peroxisomal matrix] (R-HSA-9033517) ACAA1(1-424) [cytosol] (R-HSA-9033127) ACAA1 [extracellular region] (R-HSA-6799680) ACAA1 [specific granule lumen] (R-HSA-6799608) ACAA1 [peroxisomal matrix] (R-HSA-390238)	0.527	3

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