Interaction of GRB2:SOS complex with p-SHC1

Stable Identifier
R-HSA-2730844
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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GRB2 is an adapter protein that contains a central SH2 domain flanked by N- and C-terminal SH3 domains. GRB2 acts downstream of receptor protein-tyrosine kinases and is involved in Ras and MAP kinase pathway activation by associating with the guanine exchange factor (GEF) SOS. GRB2 is constitutively bound to SOS through its SH3 domains, which interact with a proline-rich sequence in the C-terminal part of SOS (Chardin et al. 1993). GRB2-SOS complex binds to phosphotyrosine Y239 and Y317 of SHC1. SHC1 associates with the tyrosine-phosphorylated ITAMs of the FCERI beta-chain and can recruit SOS to membrane. SHC1 and SOS have also been described to associate with LAT via GRB2. Shc binding to Phospho-ITAMs (in vitro binding to phospho peptides) has never been linked to any biological function (activation) and is probably not relevant in a physiological setting.

Literature References
PubMed ID Title Journal Year
9199344 Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes

Harmer, SL, DeFranco, AL

Mol Cell Biol 1997
19909365 Adapters in the organization of mast cell signaling

Alvarez-Errico, D, Lessmann, E, Rivera, J

Immunol. Rev. 2009
8493579 Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

Chardin, P, Camonis, JH, Gale, NW, Van Aelst, L, Schlessinger, J, Wigler, MH, Bar-Sagi, D

Science 1993
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