Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
p-5Y,S1119-TEK [plasma membrane]
Stable Identifier
R-HSA-204772
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-6Y-TEK, Phosphorylated angiopoietin 1 receptor, pTEK
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Tie2 Signaling (Homo sapiens)
Interaction of SOS-1 to Tie2 bound Grb2 (Homo sapiens)
Grb2 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Homo sapiens)
Grb2 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
Interaction of Tie2 and Dok-2 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
Tie2 and Dok-2 complex [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
Interaction of Tie2 and Grb14 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
Tie2 and Grb14 complex [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
Interaction of Tie2 and Grb2 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
Grb2 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
Interaction of Tie2 and Grb7 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
Tie2:Grb7 complex [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
Interaction of Tie2 and Shc1 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK:SHC1 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
Interaction of Tie2 and Shp2 (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
pTie2 and SHP2 complex [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
Interaction of Tie2 and p85 of PI3K (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
p85 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Homo sapiens)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Homo sapiens)
Grb2 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
Trans-phosphorylation of Tie2 (Homo sapiens)
Phosphorylated Tie2 in Tie2/Akt dimer [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Homo sapiens)
Grb2 bound to Tie2 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
p-5Y,S1119-TEK [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q02763 TEK
Gene Names
TEK, TIE2, VMCM, VMCM1
Chain
signal peptide:1-22, chain:23-1124
Reference Genes
BioGPS Gene:7010 TEK
COSMIC (genes):TEK TEK
CTD Gene:7010 TEK
dbSNP Gene:7010 TEK
ENSEMBL:ENSG00000120156.22 TEK
HGNC:11724 TEK
KEGG Gene (Homo sapiens):7010 TEK
Monarch:7010 TEK
NCBI Gene:7010 TEK
OMIM:600221 TEK
UCSC:Q02763 TEK
Reference Transcript
RefSeq:NM_001290078.1 TEK
RefSeq:NM_000459.4 TEK
RefSeq:NM_001290077.1 TEK
Other Identifiers
11727406_a_at
11748375_a_at
11750679_a_at
1595_at
1596_g_at
17084130
206702_PM_at
206702_at
217711_PM_at
217711_at
3165829
3165830
3165831
3165840
3165844
3165845
3165848
3165849
3165850
3165852
3165853
3165854
3165857
3165858
3165859
3165861
3165862
3165864
3165865
3165867
3165869
3165870
3165871
3165872
3165875
3165876
3165877
3165878
3165879
7010
8154692
A_14_P116356
A_14_P136657
A_23_P374695
GE57565
GO:0000166
GO:0001525
GO:0001725
GO:0001934
GO:0001935
GO:0001938
GO:0002040
GO:0002376
GO:0003013
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005515
GO:0005524
GO:0005576
GO:0005737
GO:0005815
GO:0005856
GO:0005884
GO:0005886
GO:0005887
GO:0005902
GO:0005911
GO:0005925
GO:0006468
GO:0006629
GO:0006954
GO:0007010
GO:0007155
GO:0007163
GO:0007165
GO:0007169
GO:0007267
GO:0007507
GO:0009925
GO:0009986
GO:0010595
GO:0012501
GO:0014068
GO:0016020
GO:0016301
GO:0016310
GO:0016323
GO:0016324
GO:0016525
GO:0016740
GO:0018108
GO:0023052
GO:0030154
GO:0030334
GO:0032878
GO:0033674
GO:0034330
GO:0034446
GO:0034451
GO:0036211
GO:0038023
GO:0042802
GO:0043066
GO:0043114
GO:0043226
GO:0043235
GO:0043410
GO:0043552
GO:0045121
GO:0045766
GO:0046777
GO:0048014
GO:0048856
GO:0048870
GO:0050728
GO:0051894
GO:0051897
GO:0060089
GO:0060216
GO:0060347
GO:0070161
GO:0070374
GO:0072012
GO:0072359
GO:0140096
GO:1902533
GO:2000026
GO:2000251
GO:2000351
GO:2000352
HMNXSV003039708
Hs.287335.0.A1_3p_at
Hs.287335.0.A1_3p_x_at
ILMN_2066151
L06139_at
TC09000121.hg
g4557868_3p_at
Participates
as a component of
ANGPT1:p-5Y,S119-TEK [plasma membrane] (Homo sapiens)
Other forms of this molecule
TEK [plasma membrane]
Inferred To
phospho-kin-30 [plasma membrane]
(Caenorhabditis elegans)
Homologues of p-5Y,S1119-TEK [plasma membrane]
(Caenorhabditis elegans)
Homologues of p-5Y,S1119-TEK [plasma membrane]
(Drosophila melanogaster)
phospho-kin-9 [plasma membrane]
(Caenorhabditis elegans)
phospho-p-5Y,S1119-TEK [plasma membrane]
(Bos taurus)
phospho-p-5Y,S1119-TEK [plasma membrane]
(Caenorhabditis elegans)
phospho-p-5Y,S1119-TEK [plasma membrane]
(Canis familiaris)
phospho-p-5Y,S1119-TEK [plasma membrane]
(Danio rerio)
phospho-p-5Y,S1119-TEK [plasma membrane]
(Drosophila melanogaster)
phospho-p-5Y,S1119-TEK [plasma membrane]
(Gallus gallus)
phospho-p-5Y,S1119-TEK [plasma membrane]
(Mus musculus)
phospho-p-5Y,S1119-TEK [plasma membrane]
(Rattus norvegicus)
phospho-p-5Y,S1119-TEK [plasma membrane]
(Sus scrofa)
phospho-p-5Y,S1119-TEK [plasma membrane]
(Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 816
Coordinate
816
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 992
Coordinate
992
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1102
Coordinate
1102
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1108
Coordinate
1108
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-serine at 1119
Coordinate
1119
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 1113
Coordinate
1113
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001277006.1
,
NP_000450.2
,
NP_001277007.1
ZINC - World Drugs
TIE2_HUMAN
Guide to Pharmacology - Targets
1842
OpenTargets
ENSG00000120156
ZINC - FDA approved
TIE2_HUMAN
ZINC - Substances
TIE2_HUMAN
ZINC - Biogenic
TIE2_HUMAN
ZINC target
Q02763
PRO
Q02763
PDB
2OSC
,
7E72
,
5MYA
,
1FVR
,
4X3J
,
3L8P
,
2P4I
,
2GY5
,
6MWE
,
4K0V
,
5MYB
,
2GY7
,
2OO8
,
5UTK
,
2WQB
,
3BEA
ZINC - Investigational
TIE2_HUMAN
ZINC - Metabolites
TIE2_HUMAN
HPA
ENSG00000120156-TEK
GeneCards
Q02763
Ensembl
ENST00000380036
,
ENST00000519097
,
ENSP00000383977
,
ENSG00000120156
,
ENST00000406359
,
ENSP00000369375
,
ENSP00000430686
Pharos - Targets
Q02763
ZINC - Predictions - Purchasable
TIE2_HUMAN
Orphanet
15599
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15123-1 ANGPT2
0.743
5
UniProt:O15123 ANGPT2
1
ANGPT2 [extracellular region]
(R-HSA-204801)
0.618
4
UniProt:Q15389 ANGPT1
1
ANGPT1 [extracellular region]
(R-HSA-204854)
0.609
2
UniProt:P62158 CALM
0.462
2
IntAct:EBI-11820565 HSPA1A
0.462
2
UniProt:P29353 SHC1
5
SHC1 [cytosol]
(R-HSA-74680)
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
0.462
2
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text