Maturation of hRSV A proteins

Stable Identifier
R-HSA-9828806
Type
Pathway
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol, nucleoplasm, plasma membrane, endoplasmic reticulum lumen, endoplasmic reticulum membrane, trans-Golgi network membrane
ReviewStatus
5/5
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Maturation of hRSV A proteins
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Human respiratory syncytial virus contains 10 genes which are translated into 11 proteins, of which 2 have translation isoforms due to use of alternative translation initiation codons. These proteins function in viral replication and host interaction. Fusion protein F, glycoprotein G, and both variants of small hydrophobic protein, SH and SHt, get glycosylated and F, G, and SH later migrate to the plasma membrane where virion assembly takes place. Matrix protein M first translocates to the nucleus and back to cytosol before serving as a scaffold at the assembly site. M2-1 is also found in the nucleus. Phosphorylations, partially transient, appear to be necessary for oligomerization and function of the SH, N, P, M, and M2-1 proteins (Gan & Torres, 2011; McLellan et al, 2013; Muniyandi et al, 2018; Anderson et al, 2021).
Literature References
PubMed ID Title Journal Year
  Structural and functional aspects of the small hydrophobic (SH) protein in the human respiratory syncytial virus.

Gan, SW, Torres, J

   
24362685 Structure and function of respiratory syncytial virus surface glycoproteins

McLellan, JS, Ray, WC, Peeples, ME

Curr Top Microbiol Immunol 2013
29900500 Structure and Function of the Human Respiratory Syncytial Virus M2-1 Protein

Muniyandi, S, Pangratiou, G, Edwards, TA, Barr, JN

Subcell Biochem 2018
34372490 Functional Features of the Respiratory Syncytial Virus G Protein

Anderson, LJ, Jadhao, SJ, Paden, CR, Tong, S

Viruses 2021
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Cross References
Mondo
Authored
Stephan, R  (2023-02-18)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Stephan, R  (2023-02-18)
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