M dimer localizes to nucleus

Stable Identifier
R-HSA-9831702
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
nucleoplasm
ReviewStatus
5/5
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M dimer localizes to nucleus
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Early in hRSV infection, the matrix protein localizes to the nucleus utilizing the conventional nuclear import pathway. This is dependent on the nuclear import receptor importin-beta 1 (IMPĪ²1, KPNB1) and the guanine nucleotide-binding protein Ran (Ghildyal et al, 2003; Ghildyal et al, 2005; Ghildyal et al, 2022).
Literature References
PubMed ID Title Journal Year
35887322 Nuclear Transport of Respiratory Syncytial Virus Matrix Protein Is Regulated by Dual Phosphorylation Sites

Ghildyal, R, Teng, MN, Tran, KC, Mills, J, Casarotto, MG, Bardin, PG, Jans, DA

Int J Mol Sci 2022
16171404 Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha

Ghildyal, R, Ho, A, Wagstaff, KM, Dias, MM, Barton, CL, Jans, P, Bardin, P, Jans, DA

Biochemistry 2005
12827470 The matrix protein of Human respiratory syncytial virus localises to the nucleus of infected cells and inhibits transcription

Ghildyal, R, Baulch-Brown, C, Mills, J, Meanger, J

Arch Virol 2003
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
protein import into nucleus (0006606)
This event is regulated
Positively by
Regulator
KPNB1 [cytosol] (Homo sapiens)
Disease
Cross References
Mondo
Authored
Stephan, R  (2023-03-22)
Reviewed
Bergeron, HC  (2023-11-03)
Matthews, L  (2025-03-04)
Created
Stephan, R  (2023-03-24)
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