M dimer localizes to nucleus

Stable Identifier
R-HSA-9831702
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
M dimer localizes to nucleus
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Early in hRSV infection, the matrix protein localizes to the nucleus utilizing the conventional nuclear import pathway. This is dependent on the nuclear import receptor importin-beta 1 (IMPĪ²1, KPNB1) and the guanine nucleotide-binding protein Ran (Ghildyal et al, 2003; Ghildyal et al, 2005; Ghildyal et al, 2022).
Literature References
PubMed ID Title Journal Year
35887322 Nuclear Transport of Respiratory Syncytial Virus Matrix Protein Is Regulated by Dual Phosphorylation Sites

Mills, J, Casarotto, MG, Teng, MN, Ghildyal, R, Tran, KC, Bardin, PG, Jans, DA

Int J Mol Sci 2022
16171404 Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha

Wagstaff, KM, Ghildyal, R, Jans, P, Dias, MM, Ho, A, Bardin, P, Barton, CL, Jans, DA

Biochemistry 2005
12827470 The matrix protein of Human respiratory syncytial virus localises to the nucleus of infected cells and inhibits transcription

Baulch-Brown, C, Mills, J, Ghildyal, R, Meanger, J

Arch Virol 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
Importin subunit beta-1 [cytosol] (Mus musculus)
Disease
Authored
Stephan, R  (2023-03-22)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Stephan, R  (2023-03-24)
Cite Us!