Reactome | G is O-glycosylated

G is O-glycosylated

Stable Identifier

R-HSA-9830867

Type

Reaction [uncertain]

Species

Homo sapiens

Related Species

Human respiratory syncytial virus A

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
        
        Maturation of hRSV A proteins (Homo sapiens)
        
        G is O-glycosylated (Homo sapiens)

General

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Membrane-bound glycoprotein G is estimated to contain O-linked carbohydrates that account for approximately 55% of its mature weight. Manual assertion according to computational sequence analysis performed by UniProt shows >20 potentially O-glycosylated serine and threonine residues (Lambert, 1988; Wertz et al, 1989; Collins, 1990; Palomo et al, 1991; Collins & Mottet, 1992).

Literature References

PubMed ID	Title	Journal	Year
2005433	The G protein of human respiratory syncytial virus: significance of carbohydrate side-chains and the C-terminal end to its antigenicity Melero, JA, García-Barreno, B, Palomo, C, Peñas, C	J Gen Virol	1991
2677404	Structure and cell surface maturation of the attachment glycoprotein of human respiratory syncytial virus in a cell line deficient in O glycosylation Wertz, GW, Ball, LA, Krieger, M	J Virol	1989
1634876	Oligomerization and post-translational processing of glycoprotein G of human respiratory syncytial virus: altered O-glycosylation in the presence of brefeldin A Collins, PL, Mottet, G	J Gen Virol	1992
2164608	O glycosylation of glycoprotein G of human respiratory syncytial virus is specified within the divergent ectodomain Collins, PL	J Virol	1990
3369089	Role of oligosaccharides in the structure and function of respiratory syncytial virus glycoproteins Lambert, DM	Virology	1988

Participants

Input

N-glycan-PALM-G [trans-Golgi network membrane] (Human respiratory syncytial virus A)

Output

Mature G [trans-Golgi network membrane] (Human respiratory syncytial virus A)

Participates

as an event of

Maturation of hRSV A proteins (Homo sapiens)

Disease

Name	Identifier	Synonyms
respiratory syncytial virus infectious disease	DOID:1273

Authored

Stephan, R (2023-03-15)

Reviewed

Bergeron, HC (2023-11-03)

Created

Stephan, R (2023-03-16)

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