P protein oligomerizes

Stable Identifier
R-HSA-9825422
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
ReviewStatus
5/5
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P protein oligomerizes
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The P protein of the human respiratory syncytial virus oligomerizes, predominantly forming tetramers (Asenjo and Villanueva 2000; Castagné et al. 2004; Esperante et al. 2012; Cao et al. 2020) that have been suggested to represent dimers of dimers (Asenjo and Villanueva 2000). While bulk constitutive phosphorylation of the P protein in host cells does not appear to be a prerequisite for oligomerization, phosphorylation at specific sites may be necessary (Asenjo and Villanueva 2000; Castagné et al. 2004; Hengst & Kiefer, 2000; Llorente et al, 2008; Esperante et al, 2012).
Literature References
PubMed ID Title Journal Year
15166449 Biochemical characterization of the respiratory syncytial virus P-P and P-N protein complexes and localization of the P protein oligomerization domain

Castagné, N, Barbier, A, Bernard, J, Rezaei, H, Huet, JC, Henry, C, Costa, BD, Eléouët, JF

J Gen Virol 2004
31953395 Cryo-EM structure of the respiratory syncytial virus RNA polymerase

Cao, D, Gao, Y, Roesler, C, Rice, S, D'Cunha, P, Zhuang, L, Slack, J, Domke, M, Antonova, A, Romanelli, S, Keating, S, Forero, G, Juneja, P, Liang, B

Nat Commun 2020
10675554 Regulated but not constitutive human respiratory syncytial virus (HRSV) P protein phosphorylation is essential for oligomerization

Asenjo, A, Villanueva, N

FEBS Lett 2000
18300250 Structural properties of the human respiratory syncytial virus P protein: evidence for an elongated homotetrameric molecule that is the smallest orthologue within the family of paramyxovirus polymerase cofactors

Llorente, MT, Taylor, IA, López-Viñas, E, Gomez-Puertas, P, Calder, LJ, García-Barreno, B, Melero, JA

Proteins 2008
10949949 Domains of human respiratory syncytial virus P protein essential for homodimerization and for binding to N and NS1 protein

Hengst, U, Kiefer, P

Virus Genes 2000
22978633 Modular unfolding and dissociation of the human respiratory syncytial virus phosphoprotein p and its interaction with the m(2-1) antiterminator: a singular tetramer-tetramer interface arrangement

Esperante, SA, Paris, G, de Prat-Gay, G

Biochemistry 2012
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Cross References
Mondo
Authored
Stephan, R  (2023-03-29)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Orlic-Milacic, M  (2023-01-26)
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