Reactome | NS1 (1C) binds to NS2 (1B)

NS1 (1C) binds to NS2 (1B)

Stable Identifier

R-HSA-9832574

Type

Reaction [binding]

Species

Homo sapiens

Related Species

Human respiratory syncytial virus A

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
        
        Maturation of hRSV A proteins (Homo sapiens)
        
        NS1 (1C) binds to NS2 (1B) (Homo sapiens)

General

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RSV non-structural proteins 1C (NS1) and 1B (NS2) form a heterodimer (Swedan et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
21795342	Multiple functional domains and complexes of the two nonstructural proteins of human respiratory syncytial virus contribute to interferon suppression and cellular location Swedan, S, Andrews, J, Majumdar, T, Musiyenko, A, Barik, S	J Virol	2011

Participants

Input

Output

NS1:NS2 [cytosol] (Human respiratory syncytial virus A)

Participates

as an event of

Maturation of hRSV A proteins (Homo sapiens)

Disease

Name	Identifier	Synonyms
respiratory syncytial virus infectious disease	DOID:1273

Cross References

Mondo

0001577

Authored

Stephan, R (2023-03-30)

Reviewed

Bergeron, HC (2023-11-03)

Created

Stephan, R (2023-04-03)

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