M dimer gets exported from nucleus

Stable Identifier
R-HSA-9831677
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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M dimer gets exported from nucleus
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In order to fulfill its role as a scaffold in virus assembly, which takes place in the periplasmic region of the host cell, protein M localizes to cytosol. Nuclear export is dependent on exportin-1 (XPO1, CRM1), a component of nuclear export receptor complexes, that associates with a nuclear export signal (NES) within residues 194 to 206 of M (Ghildyal et al, 2009).
Literature References
PubMed ID Title Journal Year
19297465 The respiratory syncytial virus matrix protein possesses a Crm1-mediated nuclear export mechanism

Bardin, PG, Teng, MN, Ghildyal, R, Tran, KC, Soegiyono, L, Ho, A, Jans, DA, Dias, M

J Virol 2009
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
XPO1 [nucleoplasm] (Homo sapiens)
Disease
Authored
Stephan, R  (2023-03-22)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Stephan, R  (2023-03-24)
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