F0 is palmitoylated

Stable Identifier
R-HSA-9829047
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
endoplasmic reticulum-Golgi intermediate compartment, trans-Golgi network membrane
ReviewStatus
5/5
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F0 is palmitoylated
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Palmitoylation of prepro-fusion protein F0 of human respiratory syncytial virus (hRSV) on Cys-550 probably occurs during transport to the Golgi network as the responsible enzymes are localized in the Golgi membrane. The fatty acid is linked to cysteine via the thioester moiety. This modification does not affect F oligomerization and its significance is unknown (Arumugham et al, 1989).
Literature References
PubMed ID Title Journal Year
2732224 Fatty acid acylation of the fusion glycoprotein of human respiratory syncytial virus

Arumugham, RG, Seid, RC, Doyle, S, Hildreth, SW, Paradiso, PR

J Biol Chem 1989
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Catalyst Activity

protein-cysteine S-palmitoyltransferase activity of unknown palmitoyltransferase [endoplasmic reticulum-Golgi intermediate compartment]

Physical Entity
unknown palmitoyltransferase [endoplasmic reticulum-Golgi intermediate compartment] (Homo sapiens)
Activity
protein-cysteine S-palmitoyltransferase activity (GO:0019706)
Disease
Cross References
Mondo
Authored
Stephan, R  (2023-02-18)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Stephan, R  (2023-02-22)
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