Reactome | G is N-glycosylated

G is N-glycosylated

Stable Identifier

R-HSA-9830872

Type

Reaction [uncertain]

Species

Homo sapiens

Related Species

Human respiratory syncytial virus A

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
        
        Maturation of hRSV A proteins (Homo sapiens)
        
        G is N-glycosylated (Homo sapiens)

General

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Membrane-bound G protein gets N-glycosylated, presumably on some of its Asn residues (Lambert, 1988; McDonald et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
16513154	Evidence that maturation of the N-linked glycans of the respiratory syncytial virus (RSV) glycoproteins is required for virus-mediated cell fusion: The effect of alpha-mannosidase inhibitors on RSV infectivity Jeffree, CE, Maclellan, K, Rixon, HW, Sugrue, RJ, McDonald, TP, Brown, G, Aitken, JD, Li, P	Virology	2006
3369089	Role of oligosaccharides in the structure and function of respiratory syncytial virus glycoproteins Lambert, DM	Virology	1988

Participants

Input

G [endoplasmic reticulum membrane] (Human respiratory syncytial virus A)

Output

N-glycan G [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human respiratory syncytial virus A)

Participates

as an event of

Maturation of hRSV A proteins (Homo sapiens)

Disease

Name	Identifier	Synonyms
respiratory syncytial virus infectious disease	DOID:1273

Authored

Stephan, R (2023-03-15)

Reviewed

Bergeron, HC (2023-11-03)

Created

Stephan, R (2023-03-16)

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