N-/O-glycan-sG is secreted

Stable Identifier
R-HSA-9830804
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
endoplasmic reticulum lumen, extracellular region
ReviewStatus
5/5
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N-/O-glycan-sG is secreted
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Soluble G protein is secreted in large amounts from RSV-infected cells before the first assembled virions appear on the host cell plasma membrane (Hendricks et al, 1987; Hendricks et al, 1988). The alternative initiation codon leading to sG expression is conserved in many RSV strains. There is evidence that sG binds to glycosaminoglycans presented on the surface of other cells where it presumably functions as an antigen decoy facilitating RSV evasion of antibody-mediated restriction of replication (Escribano-Romero et al, 2004; Bukreyev et al, 2008).
Literature References
PubMed ID Title Journal Year
18611945 Soluble G protein of respiratory syncytial virus inhibits Toll-like receptor 3/4-mediated IFN-beta induction

Shingai, M, Azuma, M, Ebihara, T, Sasai, M, Funami, K, Ayata, M, Ogura, H, Tsutsumi, H, Matsumoto, M, Seya, T

Int Immunol 2008
18842713 The secreted form of respiratory syncytial virus G glycoprotein helps the virus evade antibody-mediated restriction of replication by acting as an antigen decoy and through effects on Fc receptor-bearing leukocytes

Bukreyev, A, Yang, L, Fricke, J, Cheng, L, Ward, JM, Murphy, BR, Collins, PL

J Virol 2008
15016875 The soluble form of human respiratory syncytial virus attachment protein differs from the membrane-bound form in its oligomeric state but is still capable of binding to cell surface proteoglycans

Escribano-Romero, E, Rawling, J, García-Barreno, B, Melero, JA

J Virol 2004
3585282 Appearance of a soluble form of the G protein of respiratory syncytial virus in fluids of infected cells

Hendricks, DA, Baradaran, K, McIntosh, K, Patterson, JL

J Gen Virol 1987
3373568 Further characterization of the soluble form of the G glycoprotein of respiratory syncytial virus

Hendricks, DA, McIntosh, K, Patterson, JL

J Virol 1988
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Disease
Cross References
Mondo
Authored
Stephan, R  (2023-03-15)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Stephan, R  (2023-03-15)
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