CK2 phosphorylates nascent P

Stable Identifier
R-HSA-9831514
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
ReviewStatus
5/5
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Phosphorylation of RSV P protein at S232 and S237 was found to be essential for the transcription elongation activity of RSV polymerase complex. The modifications are catalyzed by cellular casein kinase II (CKII, CK2) (Villanueva et al, 1994; Mazumder et al, 1994; Mazumder & Barik, 1994; Sanchez-Seco et al, 1995; Barik et al, 1995; Dupuy et al, 1999; Lu et al, 2002).
Literature References
PubMed ID Title Journal Year
7844563 C-terminal phosphorylation of human respiratory syncytial virus P protein occurs mainly at serine residue 232

Villanueva, N, Navarro, J, Martinez, R, Sánchez-Seco, MP

J Gen Virol 1995
8126452 Identification of a protein kinase involved in the phosphorylation of the C-terminal region of human respiratory syncytial virus P protein

García-Albert, I, Villanueva, N, Navarro, J, Méndez, E

J Gen Virol 1994
7975241 Bacterial expression of human respiratory syncytial viral phosphoprotein P and identification of Ser237 as the site of phosphorylation by cellular casein kinase II

Mazumder, B, Barik, S, Adhikary, G

Virology 1994
7491765 Phosphorylation of Ser232 directly regulates the transcriptional activity of the P protein of human respiratory syncytial virus: phosphorylation of Ser237 may play an accessory role

McLean, T, Dupuy, LC, Barik, S

Virology 1995
10482589 Casein kinase 2-mediated phosphorylation of respiratory syncytial virus phosphoprotein P is essential for the transcription elongation activity of the viral polymerase; phosphorylation by casein kinase 1 occurs mainly at Ser(215) and is without effect

Bitko, V, Dupuy, LC, Dobson, S, Barik, S

J Virol 1999
7975205 Requirement of casein kinase II-mediated phosphorylation for the transcriptional activity of human respiratory syncytial viral phosphoprotein P: transdominant negative phenotype of phosphorylation-defective P mutants

Mazumder, B, Barik, S

Virology 1994
12368320 The major phosphorylation sites of the respiratory syncytial virus phosphoprotein are dispensable for virus replication in vitro

Jin, H, Ma, CH, Brazas, R, Lu, B

J Virol 2002
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of Casein kinase II [cytosol]

Authored
Reviewed
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