F subunits form trimers at plasma membrane rafts

Stable Identifier
R-HSA-9829164
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
trans-Golgi network membrane, plasma membrane
ReviewStatus
5/5
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F subunits form trimers at plasma membrane rafts
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Homotrimers of the F1-F2 conjugate form during their targeted transport from the Golgi to the plasma membrane where they associate with lipid rafts (Routledge et al, 1987; Brock et al, 2005; Fleming et al, 2006; Oomens et al, 2006; Swanson et al, 2011).
Literature References
PubMed ID Title Journal Year
21586636 Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers

Carfi, A, Swanson, KA, Rappuoli, R, Settembre, EC, Dormitzer, PR, Mandl, CW, Dey, AK, Shaw, CA

Proc Natl Acad Sci U S A 2011
16160180 The transmembrane domain of the respiratory syncytial virus F protein is an orientation-independent apical plasma membrane sorting sequence

McGraw, PA, Crowe, JE, Heck, JM, Brock, SC

J Virol 2005
3553424 Expression of the respiratory syncytial virus 22K protein on the surface of infected HeLa cells

Samson, AC, Scott, R, Willcocks, MM, Toms, GL, Morgan, L, Routledge, EG

J Gen Virol 1987
16928754 The cytoplasmic tail of the human respiratory syncytial virus F protein plays critical roles in cellular localization of the F protein and infectious progeny production

Wertz, GW, Oomens, AG, Bevis, KP

J Virol 2006
17005642 Respiratory syncytial virus F envelope protein associates with lipid rafts without a requirement for other virus proteins

Kolokoltsov, AA, Fleming, EH, Roberts, NJ, Davey, RA, Nichols, JE

J Virol 2006
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Authored
Stephan, R  (2023-02-22)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Stephan, R  (2023-02-24)
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