F subunits form trimers at plasma membrane rafts

Stable Identifier
R-HSA-9829164
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
trans-Golgi network membrane, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
F subunits form trimers at plasma membrane rafts
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Homotrimers of the F1-F2 conjugate form during their targeted transport from the Golgi to the plasma membrane where they associate with lipid rafts (Routledge et al, 1987; Brock et al, 2005; Fleming et al, 2006; Oomens et al, 2006; Swanson et al, 2011).
Literature References
PubMed ID Title Journal Year
21586636 Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers

Swanson, KA, Settembre, EC, Shaw, CA, Dey, AK, Rappuoli, R, Mandl, CW, Dormitzer, PR, Carfi, A

Proc Natl Acad Sci U S A 2011
16160180 The transmembrane domain of the respiratory syncytial virus F protein is an orientation-independent apical plasma membrane sorting sequence

Brock, SC, Heck, JM, McGraw, PA, Crowe, JE

J Virol 2005
3553424 Expression of the respiratory syncytial virus 22K protein on the surface of infected HeLa cells

Routledge, EG, Willcocks, MM, Morgan, L, Samson, AC, Scott, R, Toms, GL

J Gen Virol 1987
16928754 The cytoplasmic tail of the human respiratory syncytial virus F protein plays critical roles in cellular localization of the F protein and infectious progeny production

Oomens, AG, Bevis, KP, Wertz, GW

J Virol 2006
17005642 Respiratory syncytial virus F envelope protein associates with lipid rafts without a requirement for other virus proteins

Fleming, EH, Kolokoltsov, AA, Davey, RA, Nichols, JE, Roberts, NJ

J Virol 2006
Participants
Input
Output
Participates
as an event of
Disease
Cross References
Mondo
Authored
Stephan, R  (2023-02-22)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Stephan, R  (2023-02-24)
Cite Us!