Nascent M2-1 binds Zn2+

Stable Identifier
R-HSA-9832006
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
ReviewStatus
5/5
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Nascent M2-1 binds Zn2+
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Protein M2-1 of human respiratory syncytial virus (hRSV) complexes with a zinc ion. This reaction is necessary for M2-1 tetramerization (Esperante et al, 2011; Esperante et al, 2013).
Literature References
PubMed ID Title Journal Year
23984912 Fine modulation of the respiratory syncytial virus M2-1 protein quaternary structure by reversible zinc removal from its Cys(3)-His(1) motif

Silva, JL, Noval, MG, Altieri, TA, de Oliveira, GA, de Prat-Gay, G, Esperante, SA

Biochemistry 2013
21877705 The respiratory syncytial virus transcription antiterminator M(2-1) is a highly stable, zinc binding tetramer with strong pH-dependent dissociation and a monomeric unfolding intermediate

Chemes, LB, de Prat-Gay, G, Sánchez, IE, Esperante, SA

Biochemistry 2011
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Authored
Stephan, R  (2023-03-24)
Reviewed
Bergeron, HC  (2023-11-10)
Created
Stephan, R  (2023-03-28)
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