Reactome | Nascent G signal peptide is cleaved at ER membrane

Nascent G signal peptide is cleaved at ER membrane

Stable Identifier

R-HSA-9830882

Type

Reaction [uncertain]

Species

Homo sapiens

Related Species

Human respiratory syncytial virus A

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
        
        Maturation of hRSV A proteins (Homo sapiens)
        
        Nascent G signal peptide is cleaved at ER membrane (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Nascent G signal peptide is cleaved at ER membrane

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The leading 65 amino acids of nascent membrane-bound G protein variant of RSV, assumed to be the signal sequence directing it to the endoplasmic reticulum (ER) membrane, are cleaved off by an unknown enzyme (Fernie et al, 1985; Ding et al, 1987). While the responsible peptidase has not been experimentally investigated, signal peptides of human proteins are cleaved by the signal peptidase complex (SPC) located at the endoplasmic reticulum membrane. This complex, which can exist in two versions, SPC-A and SPC-C, that differ in their catalytic subunits (SEC11A in SPC-A, and SEC11C in SPC-C), is known to be involved in cleavage of signal peptides in other viruses (Liaci et al. 2021), and is a plausible candidate for the membrane-bound G protein signal peptidase.

Literature References

PubMed ID	Title	Journal	Year
4031826	Kinetics of synthesis of respiratory syncytial virus glycoproteins Gerin, JL, Fernie, BF, Cote, PJ, Dapolito, G	J Gen Virol	1985
3113070	Expression and glycosylation of the respiratory syncytial virus G protein in Saccharomyces cerevisiae Wertz, GW, Wen, DZ, Ball, LA, Ding, MX, Schlesinger, MJ	Virology	1987