Reactome | F0 gets N-glycosylated

F0 gets N-glycosylated

Stable Identifier

R-HSA-9829060

Type

Reaction [uncertain]

Species

Homo sapiens

Related Species

Human respiratory syncytial virus A

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane

ReviewStatus

5/5

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
        
        Maturation of hRSV A proteins (Homo sapiens)
        
        F0 gets N-glycosylated (Homo sapiens)

General

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Prepro-fusion protein F0 of human respiratory syncytial virus (hRSV) is glycosylated during its passage from the endoplasmic reticulum (ER) membrane to the late Golgi membrane (Elango et al, 1985; Lambert 1988; Anderson et al, 1992; Swanson et al, 2011). Glycosylation happens at three residues N27, N70, and N500. The N500 modification is essential for the cell-cell fusion function of the F trimer (Zimmer et al, 2001).

Literature References

PubMed ID	Title	Journal	Year
21586636	Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers Swanson, KA, Settembre, EC, Shaw, CA, Dey, AK, Rappuoli, R, Mandl, CW, Dormitzer, PR, Carfi, A	Proc Natl Acad Sci U S A	2011
1375280	Intracellular processing of the human respiratory syncytial virus fusion glycoprotein: amino acid substitutions affecting folding, transport and cleavage Anderson, K, Stott, EJ, Wertz, GW	J Gen Virol	1992
2987829	Respiratory syncytial virus fusion glycoprotein: nucleotide sequence of mRNA, identification of cleavage activation site and amino acid sequence of N-terminus of F1 subunit Elango, N, Satake, M, Coligan, JE, Norrby, E, Camargo, E, Venkatesan, S	Nucleic Acids Res	1985
16513154	Evidence that maturation of the N-linked glycans of the respiratory syncytial virus (RSV) glycoproteins is required for virus-mediated cell fusion: The effect of alpha-mannosidase inhibitors on RSV infectivity McDonald, TP, Jeffree, CE, Li, P, Rixon, HW, Brown, G, Aitken, JD, Maclellan, K, Sugrue, RJ	Virology	2006
11312346	N-glycans of F protein differentially affect fusion activity of human respiratory syncytial virus Zimmer, G, Trotz, I, Herrler, G	J Virol	2001
3369089	Role of oligosaccharides in the structure and function of respiratory syncytial virus glycoproteins Lambert, DM	Virology	1988

Participants

Input

F0 [endoplasmic reticulum membrane] (Human respiratory syncytial virus A)

Output

N-glycan-F0 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human respiratory syncytial virus A)

Participates

as an event of

Maturation of hRSV A proteins (Homo sapiens)

Disease

Name	Identifier	Synonyms
respiratory syncytial virus infectious disease	DOID:1273

Cross References

Mondo

0001577

Authored

Stephan, R (2023-02-18)

Reviewed

Bergeron, HC (2023-11-03)

Created

Stephan, R (2023-02-22)

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