SH pentamer localizes to host cell plasma membrane

Stable Identifier
R-HSA-9831152
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
trans-Golgi network membrane, plasma membrane
ReviewStatus
5/5
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SH pentamer localizes to host cell plasma membrane
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Small hydrophobic protein SH pentamer migrates to the host cell surface (Olmstedt & Collins, 1989; Collins & Mottet, 1993). While SH is not essential for virus replication in vitro (Karron et al, 1997; Bukreyev et al, 1997), deletion mutants are attenuated in animal models suggesting that SH contributes to RSV infectivity (Bukreyev et al, 1997; Whitehead et al, 2004).
Literature References
PubMed ID Title Journal Year
9391135 Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant

Karron, RA, Buonagurio, DA, Georgiu, AF, Whitehead, SS, Adamus, JE, Clements-Mann, ML, Harris, DO, Randolph, VB, Udem, SA, Murphy, BR, Sidhu, MS

Proc Natl Acad Sci U S A 1997
8336126 Membrane orientation and oligomerization of the small hydrophobic protein of human respiratory syncytial virus

Collins, PL, Mottet, G

J Gen Virol 1993
15659757 The respiratory syncytial virus small hydrophobic protein is phosphorylated via a mitogen-activated protein kinase p38-dependent tyrosine kinase activity during virus infection

Rixon, HWM, Brown, G, Murray, JT, Sugrue, RJ

J Gen Virol 2005
9371553 Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse

Bukreyev, A, Whitehead, SS, Murphy, BR, Collins, PL

J Virol 1997
10074199 Recombinant respiratory syncytial virus bearing a deletion of either the NS2 or SH gene is attenuated in chimpanzees

Whitehead, SS, Bukreyev, A, Teng, MN, Firestone, CY, St Claire, M, Elkins, WR, Collins, PL, Murphy, BR

J Virol 1999
2649692 The 1A protein of respiratory syncytial virus is an integral membrane protein present as multiple, structurally distinct species

Olmsted, RA, Collins, PL

J Virol 1989
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Cross References
Mondo
Authored
Stephan, R  (2023-03-16)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Stephan, R  (2023-03-19)
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