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GHR(19-638) [plasma membrane]
Stable Identifier
R-HSA-982779
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Growth Hormone Receptor, GHR, GHR_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Growth hormone receptor signaling (Homo sapiens)
GH:GHR:JAK2 complex undergoes a conformational change (Homo sapiens)
Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
Growth Hormone Receptor:JAK2 [plasma membrane] (Homo sapiens)
GHR(19-638) [plasma membrane] (Homo sapiens)
GHBP binds GHR (Homo sapiens)
GHBP:GHR [plasma membrane] (Homo sapiens)
GHR(19-638) [plasma membrane] (Homo sapiens)
GHR(19-638) [plasma membrane] (Homo sapiens)
GHR internalization (Homo sapiens)
GHR(19-638) [plasma membrane] (Homo sapiens)
Growth hormone binds the growth hormone receptor (Homo sapiens)
Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
Growth Hormone Receptor:JAK2 [plasma membrane] (Homo sapiens)
GHR(19-638) [plasma membrane] (Homo sapiens)
Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
Growth Hormone Receptor:JAK2 [plasma membrane] (Homo sapiens)
GHR(19-638) [plasma membrane] (Homo sapiens)
Growth hormone receptor binds JAK2 (Homo sapiens)
GHR(19-638) [plasma membrane] (Homo sapiens)
Growth Hormone Receptor:JAK2 [plasma membrane] (Homo sapiens)
GHR(19-638) [plasma membrane] (Homo sapiens)
Growth hormone receptor binds Lyn (Homo sapiens)
Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
Growth Hormone Receptor:JAK2 [plasma membrane] (Homo sapiens)
GHR(19-638) [plasma membrane] (Homo sapiens)
Growth Hormone:Growth Hormone Receptor-JAK2 dimer:LYN [plasma membrane] (Homo sapiens)
Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
Growth Hormone Receptor:JAK2 [plasma membrane] (Homo sapiens)
GHR(19-638) [plasma membrane] (Homo sapiens)
Growth hormone receptor dimerizes (Homo sapiens)
GHBP:GHR [plasma membrane] (Homo sapiens)
GHR(19-638) [plasma membrane] (Homo sapiens)
Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
Growth Hormone Receptor:JAK2 [plasma membrane] (Homo sapiens)
GHR(19-638) [plasma membrane] (Homo sapiens)
Growth Hormone Receptor:JAK2 [plasma membrane] (Homo sapiens)
GHR(19-638) [plasma membrane] (Homo sapiens)
Lyn activates ERK (Homo sapiens)
Growth Hormone:Growth Hormone Receptor-JAK2 dimer:LYN [plasma membrane] (Homo sapiens)
Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
Growth Hormone Receptor:JAK2 [plasma membrane] (Homo sapiens)
GHR(19-638) [plasma membrane] (Homo sapiens)
Metalloprotease cleavage of GHR (Homo sapiens)
GHR(19-638) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10912 GHR
Gene Names
GHR
Chain
signal peptide:1-18, chain:19-638, chain:19-256
Reference Genes
BioGPS Gene:2690 GHR
COSMIC (genes):GHR GHR
CTD Gene:2690 GHR
dbSNP Gene:2690 GHR
ENSEMBL:ENSG00000112964 GHR
HGNC:4263 GHR
KEGG Gene (Homo sapiens):2690 GHR
Monarch:2690 GHR
NCBI Gene:2690 GHR
OMIM:600946 GHR
UCSC:P10912 GHR
Reference Transcript
RefSeq:NM_000163.4 GHR
RefSeq:NM_001242406.2 GHR
RefSeq:NM_001242403.2 GHR
RefSeq:NM_001242404.2 GHR
RefSeq:NM_001242401.3 GHR
RefSeq:NM_001242402.2 GHR
RefSeq:NM_001242460.1 GHR
RefSeq:NM_001242399.2 GHR
RefSeq:NM_001242462.1 GHR
RefSeq:NM_001242400.2 GHR
RefSeq:NM_001242405.2 GHR
Other Identifiers
0003360364
11728055_at
11752376_a_at
1215_at
160030_at
16984365
205498_at
2690
2807961
2807962
2807963
2807978
2807984
2807988
2808001
2808007
2808008
2808009
2808010
2808013
2808014
2808015
2808016
2808018
2808019
2808020
2808021
2808022
8105121
A_14_P116270
A_23_P156087
A_24_P72064
A_33_P3260733
GE59684
GO:0000187
GO:0003674
GO:0004896
GO:0004903
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0005887
GO:0006464
GO:0006790
GO:0006810
GO:0006897
GO:0007165
GO:0007259
GO:0008150
GO:0008219
GO:0009725
GO:0009755
GO:0009897
GO:0009986
GO:0016020
GO:0016021
GO:0016192
GO:0017046
GO:0019221
GO:0019530
GO:0019838
GO:0019899
GO:0019901
GO:0019903
GO:0019955
GO:0030154
GO:0031623
GO:0032094
GO:0032355
GO:0032869
GO:0032870
GO:0032991
GO:0034097
GO:0036464
GO:0040007
GO:0040014
GO:0040018
GO:0042169
GO:0042445
GO:0042531
GO:0042802
GO:0042803
GO:0042976
GO:0043025
GO:0043226
GO:0043235
GO:0043278
GO:0043434
GO:0044281
GO:0045597
GO:0046427
GO:0046898
GO:0048009
GO:0048856
GO:0050731
GO:0051384
GO:0060351
GO:0060396
GO:0060397
GO:0060416
GO:0070064
GO:0070195
GO:0070555
GO:1901215
HMNXSV003002974
HMNXSV003041248
ILMN_1775814
ILMN_1833977
ILMN_1837244
ILMN_1845433
PH_hs_0007066
TC05002346.hg
TC05002347.hg
X06562_at
g4503992_3p_at
Participates
as an input of
GHBP binds GHR (Homo sapiens)
Metalloprotease cleavage of GHR (Homo sapiens)
GHR internalization (Homo sapiens)
Growth hormone receptor binds JAK2 (Homo sapiens)
as a component of
GHBP:GHR [plasma membrane] (Homo sapiens)
Growth Hormone Receptor:JAK2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y332,Y487,Y627-GHR(19-638) [plasma membrane]
GHR(257-638) [plasma membrane]
p-5Y-GHR(19-638) [plasma membrane]
GHR(19-638) [endosome lumen]
GHR(19-256) [extracellular region]
GHR activated [plasma membrane]
Inferred To
ghr [plasma membrane]
(Xenopus tropicalis)
Ghr [plasma membrane]
(Mus musculus)
Ghost homologue of GHR(19-638) [plasma membrane]
(Canis familiaris)
ghra [plasma membrane]
(Danio rerio)
GHR [plasma membrane]
(Gallus gallus)
Activated growth hormone receptor [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001229389.1
,
NP_001229328.1
,
NP_001229331.1
,
NP_001229329.1
,
NP_001229335.1
,
NP_001229332.1
,
NP_001229391.1
,
NP_001229333.1
,
NP_001229330.1
,
NP_001229334.1
,
NP_000154.1
Guide to Pharmacology - Targets
1720
OpenTargets
ENSG00000112964
HPA
ENSG00000112964-GHR
GeneCards
P10912
Ensembl
ENSP00000230882
,
ENST00000230882
,
ENSP00000479846
,
ENST00000357703
,
ENSG00000112964
,
ENST00000615111
,
ENST00000612382
,
ENSP00000350335
,
ENST00000612626
,
ENSP00000482373
,
ENSP00000478291
,
ENST00000618088
,
ENSP00000442206
,
ENST00000537449
,
ENSP00000478332
PRO
P10912
Pharos - Targets
P10912
Orphanet
16122
GlyGen
P10912
PDB
5OHD
,
1KF9
,
2AEW
,
1HWG
,
5OEK
,
1AXI
,
1A22
,
1HWH
,
3HHR
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01241 GH1
2
GH1 [endosome lumen]
(R-HSA-8942972)
GH1 [extracellular region]
(R-HSA-422070)
0.73
4
UniProt:P23467 PTPRB
3
PTPRB [tertiary granule membrane]
(R-HSA-6801032)
PTPRB [plasma membrane]
(R-HSA-437247)
PTPRB [specific granule membrane]
(R-HSA-6799638)
0.683
3
UniProt:Q9HD43 PTPRH
0.645
4
UniProt:P26045 PTPN3
3
PTPN3 [plasma membrane]
(R-HSA-5490317)
p-S459 PTPN3 [cytosol]
(R-HSA-8868111)
PTPN3 [cytosol]
(R-HSA-8867650)
0.645
4
UniProt:P17706 PTPN2
2
PTPN2 [cytosol]
(R-HSA-997292)
PTPN2 [nucleoplasm]
(R-HSA-9008891)
0.645
8
UniProt:P18031 PTPN1
1
PTPN1 [cytosol]
(R-HSA-210625)
0.645
5
UniProt:Q16829 DUSP7
2
DUSP7 [cytosol]
(R-HSA-5675346)
DUSP7 [nucleoplasm]
(R-HSA-203791)
0.558
2
UniProt:P43378 PTPN9
1
PTPN9 [nucleoplasm]
(R-HSA-9008907)
0.558
2
UniProt:P16333 NCK1
2
NCK1 [plasma membrane]
(R-HSA-202992)
NCK1 [cytosol]
(R-HSA-197954)
0.536
3
UniProt:P10912 GHR
7
p-Y332,Y487,Y627-GHR(19-638) [plasma membrane]
(R-HSA-1169226)
GHR(257-638) [plasma membrane]
(R-HSA-1168803)
p-5Y-GHR(19-638) [plasma membrane]
(R-HSA-1168904)
GHR(19-638) [endosome lumen]
(R-HSA-1169263)
GHR(19-256) [extracellular region]
(R-HSA-1168821)
GHR(19-638) [plasma membrane]
(R-HSA-982779)
GHR activated [plasma membrane]
(R-HSA-1168385)
0.512
4
UniProt:Q9JLI4 NCOA6
0.508
2
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