Reactome | GHR(19-638) [plasma membrane]

GHR(19-638) [plasma membrane]

Stable Identifier

R-HSA-982779

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Growth Hormone Receptor, GHR, GHR_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P10912 GHR

Gene Names

GHR

Chain

signal peptide:1-18, chain:19-638, chain:19-256

Reference Genes

BioGPS Gene:2690 GHR

COSMIC (genes):GHR GHR

CTD Gene:2690 GHR

dbSNP Gene:2690 GHR

ENSEMBL:ENSG00000112964 GHR

ENSEMBL_homo_sapiens_GENE:ENSG00000112964.14 GHR

HGNC:4263 GHR

KEGG Gene (Homo sapiens):2690 GHR

Monarch:2690 GHR

NCBI Gene:2690 GHR

OMIM:600946 GHR

UCSC:P10912 GHR

Reference Transcript

Other Identifiers

11728055_at

11752376_a_at

1215_at

160030_at

16984365

205498_PM_at

205498_at

2690

2807961

2807962

2807963

2807978

2807984

2807988

2808001

2808007

2808008

2808009

2808010

2808013

2808014

2808015

2808016

2808018

2808019

2808020

2808021

2808022

8105121

A_14_P116270

A_23_P156087

A_24_P72064

A_33_P3260733

GE59684

GO:0004896

GO:0004903

GO:0005515

GO:0005576

GO:0005615

GO:0005829

GO:0005886

GO:0006790

GO:0006897

GO:0007259

GO:0008289

GO:0009629

GO:0009725

GO:0009755

GO:0009897

GO:0009986

GO:0016020

GO:0016192

GO:0017046

GO:0019221

GO:0019530

GO:0019838

GO:0019901

GO:0019903

GO:0019955

GO:0023052

GO:0030154

GO:0031623

GO:0032094

GO:0032107

GO:0032355

GO:0032869

GO:0032870

GO:0034097

GO:0036211

GO:0036464

GO:0040014

GO:0040018

GO:0042169

GO:0042445

GO:0042531

GO:0042802

GO:0042803

GO:0043025

GO:0043226

GO:0043235

GO:0043406

GO:0043434

GO:0045597

GO:0046427

GO:0046898

GO:0048009

GO:0048856

GO:0050731

GO:0051384

GO:0060089

GO:0060351

GO:0060396

GO:0060416

GO:0070064

GO:0070195

GO:0070555

HMNXSV003002974

HMNXSV003041248

ILMN_1775814

PH_hs_0007066

TC05002346.hg

TC05002347.hg

X06562_at

g4503992_3p_at

Participates

as an input of

as a component of

Other forms of this molecule

p-Y332,Y487,Y627-GHR(19-638) [plasma membrane]

GHR(257-638) [plasma membrane]

p-5Y-GHR(19-638) [plasma membrane]

GHR(19-638) [endosome lumen]

GHR(19-256) [extracellular region]

GHR activated [plasma membrane]

Inferred To

Ghr [plasma membrane] (Mus musculus)

Ghost homologue of GHR(19-638) [plasma membrane] (Bos taurus)

Ghost homologue of GHR(19-638) [plasma membrane] (Canis familiaris)

Ghost homologue of GHR(19-638) [plasma membrane] (Sus scrofa)

ghra [plasma membrane] (Danio rerio)

GHR [plasma membrane] (Gallus gallus)

Activated growth hormone receptor [plasma membrane] (Rattus norvegicus)

let-805 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001229331.1, NP_001229333.1, NP_001229335.1, NP_000154.1, NP_001229328.1, NP_001229389.1, NP_001229334.1, NP_001229332.1, NP_001229329.1, NP_001229391.1, NP_001229330.1

Guide to Pharmacology - Targets

1720

OpenTargets

ENSG00000112964

GeneCards

P10912

HPA

ENSG00000112964-GHR

Ensembl

ENSP00000478291, ENST00000357703, ENST00000537449, ENSP00000442206, ENSG00000112964, ENST00000612382, ENSP00000478332, ENSP00000230882, ENSP00000482373, ENST00000612626, ENSP00000350335, ENST00000230882, ENST00000615111, ENSP00000479846, ENST00000618088

PRO

P10912

Pharos - Targets

P10912

Orphanet

16122

PDB

1HWH, 1A22, 6I5J, 5OHD, 1HWG, 3HHR, 2AEW, 1AXI, 5OEK, 6I5N, 1KF9

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01241 GH1	2	GH1 [endosome lumen] (R-HSA-8942972) GH1 [extracellular region] (R-HSA-422070)	0.73	4
UniProt:P23467 PTPRB	3	PTPRB [specific granule membrane] (R-HSA-6799638) PTPRB [plasma membrane] (R-HSA-437247) PTPRB [tertiary granule membrane] (R-HSA-6801032)	0.683	3
UniProt:Q9HD43 PTPRH			0.645	4
UniProt:P26045 PTPN3	3	PTPN3 [plasma membrane] (R-HSA-5490317) p-S459 PTPN3 [cytosol] (R-HSA-8868111) PTPN3 [cytosol] (R-HSA-8867650)	0.645	4
UniProt:P17706 PTPN2	3	p-PTPN2 [cytosol] (R-HSA-9836510) PTPN2 [nucleoplasm] (R-HSA-9008891) PTPN2 [cytosol] (R-HSA-997292)	0.645	8
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.645	5
UniProt:Q16829 DUSP7	2	DUSP7 [cytosol] (R-HSA-5675346) DUSP7 [nucleoplasm] (R-HSA-203791)	0.558	2
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.558	2
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.536	3
UniProt:P10912 GHR	7	p-Y332,Y487,Y627-GHR(19-638) [plasma membrane] (R-HSA-1169226) GHR(257-638) [plasma membrane] (R-HSA-1168803) p-5Y-GHR(19-638) [plasma membrane] (R-HSA-1168904) GHR(19-638) [endosome lumen] (R-HSA-1169263) GHR(19-256) [extracellular region] (R-HSA-1168821) GHR(19-638) [plasma membrane] (R-HSA-982779) GHR activated [plasma membrane] (R-HSA-1168385)	0.512	4
UniProt:Q9JLI4 NCOA6			0.508	2

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