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SCN5A [plasma membrane]
Stable Identifier
R-HSA-443382
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Sodium channel protein type 5 subunit alpha, SCN5A_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Interaction between L1 and Ankyrins (Homo sapiens)
Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
SCNAs:SCNBs [plasma membrane] (Homo sapiens)
SCNAs [plasma membrane] (Homo sapiens)
SCN5A [plasma membrane] (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin:KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
SCNAs:SCNBs [plasma membrane] (Homo sapiens)
SCNAs [plasma membrane] (Homo sapiens)
SCN5A [plasma membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Phase 0 - rapid depolarisation (Homo sapiens)
SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Homo sapiens)
SCNAs:SCNBs [plasma membrane] (Homo sapiens)
SCNAs [plasma membrane] (Homo sapiens)
SCN5A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14524 SCN5A
Gene Names
SCN5A
Chain
chain:1-2016
Reference Genes
BioGPS Gene:6331 SCN5A
COSMIC (genes):SCN5A SCN5A
CTD Gene:6331 SCN5A
dbSNP Gene:6331 SCN5A
ENSEMBL:ENSG00000183873 SCN5A
HGNC:10593 SCN5A
Monarch:6331 SCN5A
NCBI Gene:6331 SCN5A
OMIM:600163 SCN5A
UCSC:Q14524 SCN5A
Reference Transcript
RefSeq:NM_001099405.1 SCN5A
RefSeq:NM_000335.4 SCN5A
RefSeq:NM_001099404.1 SCN5A
RefSeq:NM_198056.2 SCN5A
RefSeq:NM_001160160.1 SCN5A
RefSeq:NM_001160161.1 SCN5A
Other Identifiers
11731350_a_at
11734577_a_at
11745665_a_at
11751890_a_at
11762784_at
16952280
207413_PM_s_at
207413_s_at
2669645
2669646
2669647
2669648
2669649
2669650
2669651
2669652
2669653
2669654
2669655
2669656
2669658
2669660
2669666
2669667
2669668
2669669
2669671
2669672
2669675
2669677
2669678
2669682
2669683
2669684
2669687
2669689
2669691
2669693
2669694
2669695
2669696
2669697
2669698
2669703
2669704
2669705
2669710
2669711
2669712
2669713
2669714
2669715
2669716
2669727
31490_at
6331
8086222
A_23_P21063
A_24_P128233
A_33_P3350547
A_33_P3391455
GE80906
GO:0001518
GO:0002027
GO:0003012
GO:0003161
GO:0003231
GO:0003360
GO:0005215
GO:0005216
GO:0005248
GO:0005261
GO:0005272
GO:0005515
GO:0005516
GO:0005654
GO:0005730
GO:0005737
GO:0005783
GO:0005886
GO:0005901
GO:0006811
GO:0006814
GO:0008092
GO:0009986
GO:0010765
GO:0014704
GO:0014894
GO:0016020
GO:0016328
GO:0017134
GO:0019899
GO:0019901
GO:0019904
GO:0021537
GO:0021549
GO:0030018
GO:0030315
GO:0030506
GO:0031625
GO:0034220
GO:0034702
GO:0035725
GO:0042383
GO:0042475
GO:0043226
GO:0044325
GO:0045760
GO:0048471
GO:0048856
GO:0050679
GO:0050998
GO:0051899
GO:0055085
GO:0060048
GO:0060307
GO:0060371
GO:0060372
GO:0060373
GO:0070161
GO:0071277
GO:0086002
GO:0086004
GO:0086005
GO:0086006
GO:0086010
GO:0086012
GO:0086014
GO:0086015
GO:0086016
GO:0086043
GO:0086045
GO:0086046
GO:0086047
GO:0086048
GO:0086060
GO:0086061
GO:0086062
GO:0086063
GO:0086067
GO:0086091
GO:0097110
GO:0098912
GO:1902305
HMNXSV003054044
ILMN_1690160
ILMN_1694956
ILMN_1773802
M77235_at
PH_hs_0031969
TC03001297.hg
TC03002864.hg
g4506808_3p_s_at
Participates
as a member of
SCNAs [plasma membrane] (Homo sapiens)
Inferred To
SCN5A [plasma membrane]
(Bos taurus)
Cross References
ZINC - World Drugs
SCN5A_HUMAN
Guide to Pharmacology - Targets
582
OpenTargets
ENSG00000183873
ENSEMBL
ENST00000423572
,
ENSP00000328968
,
ENSP00000398266
,
ENSP00000333674
,
ENST00000327956
,
ENST00000333535
ZINC - FDA approved
SCN5A_HUMAN
ZINC - Substances
SCN5A_HUMAN
ZINC - Biogenic
SCN5A_HUMAN
ZINC target
Q14524
PRO
Q14524
GlyGen
Q14524
PDB
4OVN
,
4DJC
,
4DCK
,
4JQ0
,
5DBR
,
2L53
,
6MUD
,
7L83
,
6LQA
,
7DTC
,
2KBI
ZINC - Investigational
SCN5A_HUMAN
HPA
ENSG00000183873-SCN5A
Pharos - Targets
Q14524
Orphanet
SCN5A
ZINC - Predictions - Purchasable
SCN5A_HUMAN
HMDB Protein
HMDBP09086
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26045 PTPN3
3
PTPN3 [cytosol]
(R-HSA-8867650)
p-S459 PTPN3 [cytosol]
(R-HSA-8868111)
PTPN3 [plasma membrane]
(R-HSA-5490317)
0.527
2
UniProt:Q99873 PRMT1
2
PRMT1 [nucleoplasm]
(R-HSA-3215140)
PRMT1 [cytosol]
(R-HSA-9632173)
0.471
2
UniProt:O60678 PRMT3
1
PRMT3 [cytosol]
(R-HSA-8876692)
0.471
2
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