Reactome | p-IGFBP1 [endoplasmic reticulum lumen]

p-IGFBP1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8957029

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

IGFBP1, Insulin-like growth factor-binding protein 1, IBP1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P08833 IGFBP1

Gene Names

IGFBP1, IBP1

Chain

signal peptide:1-25, chain:26-259

Reference Genes

BioGPS Gene:3484 IGFBP1

COSMIC (genes):IGFBP1 IGFBP1

CTD Gene:3484 IGFBP1

dbSNP Gene:3484 IGFBP1

ENSEMBL:ENSG00000146678.10 IGFBP1

HGNC:5469 IGFBP1

KEGG Gene (Homo sapiens):3484 IGFBP1

Monarch:3484 IGFBP1

NCBI Gene:3484 IGFBP1

OMIM:146730 IGFBP1

UCSC:P08833 IGFBP1

Reference Transcript

RefSeq:NM_000596.2 IGFBP1

Other Identifiers

11717473_s_at

1232_s_at

17045838

205302_PM_at

205302_at

3000516

3000517

3000518

3000519

3000521

3000522

3000524

3000526

3000527

3484

8132694

A_23_P42868

GE508365

GO:0005102

GO:0005515

GO:0005520

GO:0005576

GO:0005615

GO:0005783

GO:0005788

GO:0005794

GO:0007165

GO:0007568

GO:0008286

GO:0010259

GO:0014070

GO:0019838

GO:0023052

GO:0030307

GO:0031994

GO:0031995

GO:0042246

GO:0043226

GO:0043567

GO:0048856

GO:0090090

HMNXSV003028591

ILMN_1728445

ILMN_2387385

M74587_rna1_s_at

PH_hs_0019089

TC07000294.hg

g4504614_3p_at

Participates

as a member of

FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

IGFBP1 [extracellular region]

IGFBP1 [endoplasmic reticulum lumen]

Inferred To

phospho-IGFBP1 [endoplasmic reticulum lumen] (Bos taurus)

phospho-IGFBP1 [endoplasmic reticulum lumen] (Sus scrofa)

phospho-Igfbp1 [endoplasmic reticulum lumen] (Mus musculus)

phospho-Igfbp1 [endoplasmic reticulum lumen] (Rattus norvegicus)

phospho-p-IGFBP1 [endoplasmic reticulum lumen] (Danio rerio)

phospho-p-IGFBP1 [endoplasmic reticulum lumen] (Gallus gallus)

phospho-igfbp1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_000587.1

OpenTargets

ENSG00000146678

ZINC - Substances

IBP1_HUMAN

GeneCards

P08833

HPA

ENSG00000146678-IGFBP1

ZINC target

P08833

Ensembl

ENSP00000275525, ENST00000275525, ENSG00000146678

PRO

P08833

Pharos - Targets

P08833

PDB

1ZT5, 2DSQ, 1ZT3

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05019 IGF1	2	IGF1 [platelet alpha granule lumen] (R-HSA-139878) IGF1 [extracellular region] (R-HSA-2404178)	0.623	2
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [cytosol] (R-HSA-5654207) SPRED1 [plasma membrane] (R-HSA-5658225)	0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:O14901 KLF11			0.556	3