Reactome | RPL18 [cytosol]

RPL18 [cytosol]

Stable Identifier

R-HSA-72420

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L18, Q07020

Locations in the PathwayBrowser for interactor UniProt:P03372 ESR1

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus-Host Interactions (Homo sapiens)
        
        NS1 binds RPL18 (Homo sapiens)
        
        RPL18 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q07020 RPL18

Gene Names

RPL18

Chain

initiator methionine:1, chain:2-188

Reference Genes

BioGPS Gene:6141 RPL18

COSMIC - genes:RPL18 RPL18

CTD Gene:6141 RPL18

dbSNP Gene:6141 RPL18

ENSEMBL:ENSG00000063177 RPL18

HGNC:10310 RPL18

KEGG:hsa:6141 RPL18

Monarch:6141 RPL18

NCBI Gene:6141 RPL18

OMIM:604179 RPL18

UCSC:Q07020 RPL18

Reference Transcript

Other Identifiers

11744147_x_at

11763719_a_at

16873987

18671277

18671278

18671279

18671280

18671281

18671282

18671283

18671284

18671285

18671286

18671287

18671288

18671289

18671290

18671291

18671292

200022_PM_at

200022_at

214335_PM_at

214335_at

31546_at

3634715

3867222

3867224

3867225

3867226

3867227

3867228

3867229

3867230

3867231

3867232

3867233

3867234

3867235

3867236

3867237

3867238

3867239

3867240

6141

7892519

7892817

7892868

7893133

7894114

7894858

7895518

7896349

8038086

A_23_P142146

A_24_P356721

GE507012

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005730

GO:0005737

GO:0005783

GO:0005791

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0016020

GO:0022625

GO:0022626

GO:1990904

HMNXSV003025887

Hs.317387.0.S1_3p_x_at

Hs.75458.2.S1_3p_at

Hs.75458.2.S1_3p_x_at

ILMN_1695598

ILMN_2230624

L11566_at

PH_hs_0030088

PH_hs_0035920

TC19001687.hg

g4506606_3p_at

p8399

p8400

Participates

as a component of

as an input of

NS1 binds RPL18 (Homo sapiens)

Inferred To

RPL18B [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of RPL18 [cytosol] (Gallus gallus)

Homologues of RPL18 [cytosol] (Saccharomyces cerevisiae)

Homologues of RPL18 [cytosol] (Schizosaccharomyces pombe)

RpL18 [cytosol] (Drosophila melanogaster)

RPL18A [cytosol] (Saccharomyces cerevisiae)

Rpl18 [cytosol] (Mus musculus)

Rpl18 [cytosol] (Rattus norvegicus)

rpl18 [cytosol] (Danio rerio)

rpl18 [cytosol] (Dictyostelium discoideum)

rpl18 [cytosol] (Xenopus tropicalis)

rpl1802 [cytosol] (Schizosaccharomyces pombe)

rpl1801 [cytosol] (Schizosaccharomyces pombe)

RPL18 [cytosol] (Bos taurus)

RPL18 [cytosol] (Canis familiaris)

RPL18 [cytosol] (Plasmodium falciparum)

RPL18 [cytosol] (Sus scrofa)

rpl-18 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000970.1, NP_001257419.1

OpenTargets

ENSG00000063177

ENSEMBL

ENSG00000063177, ENST00000549920, ENSP00000447001, ENST00000552588, ENSP00000449204

GeneCards

RPL18

HPA

ENSG00000063177-RPL18

PRO

Q07020

Pharos - Targets

Q07020

GlyGen

Q07020

Orphanet

RPL18

PDB

9AZS, 8FKR, 6ZM7, 6XA1, 8FLA, 6IP6, 9G8M, 9C3H, 9B0G, 6OLI, 7XNY, 9B11, 8OHD, 6ZMO, 8FL2, 8UIY, 8QYX, 8K2C, 8IPX, 8OJ8, 8JDM, 8Y0W, 8UKB, 8G61, 6OM0, 8UIK, 6Y2L, 8FKW, 8FKV, 8GLP, 8FKP, 6QZP, 6LSR, 6Y6X, 6ZVK, 6W6L, 8INF, 8IDT, 7A01, 8IR1, 8FKQ, 6IP5, 8FLB, 8FKZ, 8UJJ, 6Z6M, 8G5Z, 6ZMI, 8G60, 8UJB, 9B0H, 9GMO, 8FL3, 8QFD, 8UIZ, 8XSZ, 8G6J, 8IPY, 6LSS, 8FLC, 4UG0, 8JDJ, 8UJC, 8INK, 6OLZ, 6OLF, 9B0O, 6OLG, 9B0Q, 9B0F, 6ZME, 8A3D, 8FL6, 5T2C, 7F5S, 6LU8, 8FKT, 7OW7, 8FKY, 8FLE, 8YOO, 8IR3, 6IP8, 8Y0X, 6Z6L, 8IFE, 4V6X, 8UJ9, 8IDY, 5LKS, 6OM7, 8JDK, 9B0W, 8UJD, 8QOI, 9B0R, 8FKU, 9GY4, 7BHP, 5AJ0, 9AZC, 8OJ0, 8RL2, 8FL0, 8FKS, 8FLD, 8INE, 8YOP, 6Y0G, 9B0P, 7XNX, 8XSY, 6Z6N, 9QIW, 9B0J, 9B0S, 8FL4, 8XSX, 8IE3, 8IFD, 9B0N, 9AZN, 8FLF, 8JDL, 8G5Y, 6OLE, 8OJ5, 8FL9, 8UJK, 6LQM, 6Y57, 8FL7, 8FKX, 7QVP, 8IPD

Interactors (69)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.669	3
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.643	4
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.643	3
UniProt:P82933 MRPS9	1	MRPS9 [mitochondrial inner membrane] (R-HSA-5368194)	0.643	4
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.643	3
UniProt:Q9C0C9 UBE2O	1	UBE2O [cytosol] (R-HSA-947641)	0.643	5
UniProt:Q9Y3T9 NOC2L	1	NOC2L [nucleoplasm] (R-HSA-3222129)	0.643	4
UniProt:Q03701 CEBPZ			0.643	5
UniProt:Q9GZR2 REXO4			0.643	3
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.564	3
UniProt:P54253 ATX1			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	12
UniProt:Q9UQ80 PA2G4	2	PA2G4 [azurophil granule lumen] (R-HSA-6799205) PA2G4 [extracellular region] (R-HSA-6806200)	0.528	2
UniProt:Q8N8A6 DDX51			0.527	2
UniProt:Q9Y291 MRPS33	1	MRPS33 [mitochondrial inner membrane] (R-HSA-5368228)	0.527	3
UniProt:Q96CB9 NSUN4	1	NSUN4 [mitochondrial matrix] (R-HSA-6793068)	0.527	2
UniProt:P62424 RPL7A	1	RPL7A [cytosol] (R-HSA-72488)	0.527	4
UniProt:P42696 RBM34			0.527	2
UniProt:P51608 MECP2			0.527	3
UniProt:Q68D10 SPT2			0.527	2
UniProt:P55209 NP1L1			0.527	4
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P46779 RPL28	1	RPL28 [cytosol] (R-HSA-72444)	0.527	2
UniProt:Q9BZE4 GTPB4			0.527	3
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.527	2
UniProt:Q15050 RRS1			0.527	2
UniProt:Q9BYC9 MRPL20	1	MRPL20 [mitochondrial inner membrane] (R-HSA-5368243)	0.527	2
UniProt:Q9Y3D5 MRPS18C	1	MRPS18C [mitochondrial inner membrane] (R-HSA-5368218)	0.527	2
UniProt:O00567 NOP56	2	NOP56 [nucleoplasm] (R-HSA-6790696) NOP56 [cytosol] (R-HSA-391293)	0.527	2
UniProt:Q03188 CENPC	2	CENPC [nucleoplasm] (R-HSA-5633512) CENPC1 [cytosol] (R-HSA-375292)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.527	3
UniProt:Q13823 NOG2			0.527	2
UniProt:Q9GZR7 DDX24			0.527	2
UniProt:P61247 RPS3A	2	RPS3A [cytosol] (R-HSA-72373) RPS3A [nucleoplasm] (R-HSA-6791182)	0.527	2
UniProt:O60832 DKC1	1	DKC1 [nucleoplasm] (R-HSA-163102)	0.527	2
UniProt:P62917 RPL8	3	RPL8 [cytosol] (R-HSA-72490) RPL8 [nucleoplasm] (R-HSA-9630985) 3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976)	0.527	2
UniProt:O60287 NPA1P			0.527	2
UniProt:P40429 RPL13A	2	RPL13A [cytosol] (R-HSA-72412) p-RPL13A [cytosol] (R-HSA-156829)	0.527	3
UniProt:Q96ME7 ZN512			0.527	2
UniProt:Q9NVX2 NLE1			0.527	3
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.527	2
UniProt:Q13206 DDX10			0.527	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	2
UniProt:Q9UII4 HERC5	1	HERC5 [cytosol] (R-HSA-936553)	0.527	2
UniProt:P49356 FNTB	1	FNTB [cytosol] (R-HSA-2530482)	0.527	3
UniProt:Q96GQ7 DDX27			0.527	2
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.527	2
UniProt:Q8TDN6 BRX1			0.527	2
UniProt:P17026 ZNF22			0.527	2
UniProt:P82664 MRPS10	2	MRPS10 [mitochondrial inner membrane] (R-HSA-5368190) MRPS10 [mitochondrial matrix] (R-HSA-9839687)	0.527	3
UniProt:Q15397 PUM3			0.527	2
UniProt:Q96K80 ZC3HA			0.527	2
UniProt:Q9NX20 MRPL16	1	MRPL16 [mitochondrial inner membrane] (R-HSA-5368216)	0.527	2
UniProt:Q8WTT2 NOC3L			0.527	2
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.527	2
UniProt:Q9Y4C8 RBM19			0.527	2
UniProt:Q99733 NP1L4			0.527	2
UniProt:Q14690 PDCD11	1	PDCD11 [nucleoplasm] (R-HSA-6790646)	0.527	3
UniProt:Q13084 MRPL28	1	MRPL28 [mitochondrial inner membrane] (R-HSA-5368246)	0.527	2
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.527	2
UniProt:P62888 RPL30	1	RPL30 [cytosol] (R-HSA-72452)	0.527	2
UniProt:Q6DKK2 TTC19	1	TTC19 [mitochondrial inner membrane] (R-HSA-9906047)	0.527	3
UniProt:Q9UN86 G3BP2	1	G3BP2 [cytosol] (R-HSA-9729507)	0.527	2
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.483	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	12
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-ESR1 [cytosol] (R-HSA-9632177) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

Cite Us!