Reactome | RpL18 [cytosol]

RpL18 [cytosol]

Stable Identifier

R-DME-72420

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

RPL18, Q9VS34

Locations in the PathwayBrowser

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Metabolism of RNA (Drosophila melanogaster)

- Nonsense-Mediated Decay (NMD) (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Drosophila melanogaster)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL18 [cytosol] (Drosophila melanogaster)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL18 [cytosol] (Drosophila melanogaster)
    - SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL18 [cytosol] (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Drosophila melanogaster)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL18 [cytosol] (Drosophila melanogaster)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL18 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VS34

Gene Names

RpL18

Reference Genes

BioGPS Gene:38794 RpL18

ENSEMBL:FBgn0035753

FlyBase:FBgn0035753

KEGG:dme:Dmel_CG8615 RpL18

Monarch:38794 RpL18

NCBI Gene:38794 RpL18

UCSC:Q9VS34 RpL18

Reference Transcript

Other Identifiers

148318_at

1629400_at

38794

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005737

GO:0005840

GO:0006412

GO:0022625

GO:0022626

GO:1990904

Participates

as a component of

Inferred From

RPL18 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001286966.1, NP_001261501.1, NP_648091.1

ENSEMBL

FBpp0305562, FBgn0035753, FBpp0311286, FBtr0333370, FBtr0076892, FBpp0076602, FBtr0345036

FlyBase

FBgn0035753

PRO

Q9VS34

PDB

6XU8, 6XU7, 6XU6, 4V6W

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