NS1 binds RPL18

Stable Identifier
R-HSA-9921306
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
cytosol
ReviewStatus
5/5
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NS1 binds RPL18
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In human Huh-7 cells infected with DENV2 (strain 16681), DENV NS1 interacts with the large ribosomal subunit protein eL18 (RPL18). Silencing RPL18 in these cells significantly reduces viral translation, replication, and viral yield. The requirement of RPL18 for viral translation/replication was also confirmed in monkey Vero cells using a DENV4 replicon, suggesting that RPL18 is required during the DENV replicative cycle (Cervantes-Salazar et al., 2015).
Literature References
PubMed ID Title Journal Year
26092250 Dengue virus NS1 protein interacts with the ribosomal protein RPL18: this interaction is required for viral translation and replication in Huh-7 cells

Cervantes-Salazar, M, Angel-Ambrocio, AH, Soto-Acosta, R, Bautista-Carbajal, P, Hurtado-Monzon, AM, Alcaraz-Estrada, SL, Ludert, JE, Del Angel, RM

Virology 2015
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-09-08)
Reviewed
Roque Ascenção, F  (2025-10-29)
Mansur, DS  (2025-10-29)
Created
Stephan, R  (2024-09-09)
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