Reactome | NOS2 [nucleoplasm]

NOS2 [nucleoplasm]

Stable Identifier

R-HSA-9636250

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nitric oxide synthase, inducible, iNOS

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Infection with Mycobacterium tuberculosis (Homo sapiens)
      - Response of Mtb to phagocytosis (Homo sapiens)
        
        Suppression of phagosomal maturation (Homo sapiens)
        
        Inhibition of nitric oxide production (Homo sapiens)
        
        NOS2 gene produces NOS2 protein (Homo sapiens)
        
        NOS2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35228 NOS2

Gene Names

NOS2, NOS2A

Chain

chain:1-1153

Reference Genes

BioGPS Gene:4843 NOS2

COSMIC (genes):NOS2 NOS2

CTD Gene:4843 NOS2

dbSNP Gene:4843 NOS2

ENSEMBL:ENSG00000007171 NOS2

ENSEMBL_homo_sapiens_GENE:ENSG00000007171.19 NOS2

HGNC:7873 NOS2

KEGG Gene (Homo sapiens):4843 NOS2

Monarch:4843 NOS2

NCBI Gene:4843 NOS2

OMIM:163730 NOS2

UCSC:P35228 NOS2

Reference Transcript

Other Identifiers

11724403_at

11752035_a_at

11752213_a_at

1418_at

1419_g_at

16842517

1948_f_at

210037_PM_s_at

210037_s_at

2576342

3714422

3714424

3748390

3748392

3750338

3750346

3750376

3750377

3750378

3750379

3750380

3750381

3750382

3750383

3750384

3750385

3750386

3750388

3750391

3750393

3750396

3750397

3750398

3750399

3750401

3750403

3750404

3750405

3750406

3750407

3750409

3750410

3750411

3750412

3750413

3750415

3750416

3750417

3750418

3750421

3750422

3750423

4843

8013536

A_23_P502464

D29675_at

D29675_s_at

GE61880

GO:0001666

GO:0001912

GO:0002227

GO:0002376

GO:0003013

GO:0003824

GO:0004517

GO:0005515

GO:0005516

GO:0005634

GO:0005654

GO:0005737

GO:0005777

GO:0005782

GO:0005829

GO:0005856

GO:0005886

GO:0006091

GO:0006520

GO:0006527

GO:0006801

GO:0006809

GO:0006954

GO:0007263

GO:0007623

GO:0009617

GO:0009725

GO:0010181

GO:0010629

GO:0012501

GO:0016491

GO:0018119

GO:0020037

GO:0023052

GO:0030163

GO:0030863

GO:0032310

GO:0032496

GO:0032755

GO:0032757

GO:0034617

GO:0034618

GO:0036211

GO:0042127

GO:0042177

GO:0042742

GO:0042803

GO:0043226

GO:0043457

GO:0045454

GO:0045776

GO:0046872

GO:0048471

GO:0050660

GO:0050661

GO:0050796

GO:0050829

GO:0051712

GO:0071222

GO:0071346

GO:0071466

GO:0098542

GO:1900015

HMNXSV003026794

HMNXSV003051116

ILMN_1747882

ILMN_1748765

ILMN_2322831

PH_hs_0027962

TC17002562.hg

TC17002894.hg

X85781_s_at

g404048_3p_a_at

Participates

as an output of

NOS2 gene produces NOS2 protein (Homo sapiens)

Other forms of this molecule

NOS2 [peroxisomal matrix]

NOS2 [cytosol]

Cross References

RefSeq

XP_011523161.1, NP_000616.3

Guide to Pharmacology - Targets

1250

OpenTargets

ENSG00000007171

IntEnz

1.14.13.39

HPA

ENSG00000007171-NOS2

GeneCards

P35228

Ensembl

ENSP00000327251, ENST00000313735, ENSG00000007171

ZINC target

P35228

PRO

P35228

Pharos - Targets

P35228

HMDB Protein

HMDBP00926

PDB

2LL6, 3EJ8, 3E7G, 4NOS, 1NSI, 2NSI, 5TP6, 6JWM, 6KEY, 6JWN, 4CX7, 3HR4, 5XN3

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.499	8
UniProt:P05109 S100A8	3	S100A8 [secretory granule lumen] (R-HSA-6804772) S100A8 [cytosol] (R-HSA-9626834) S100A8 [extracellular region] (R-HSA-5432846)	0.462	4
UniProt:P06702 S100A9	3	S100A9 [secretory granule lumen] (R-HSA-6804774) S100A9 [cytosol] (R-HSA-9626869) S100A9 [extracellular region] (R-HSA-5432857)	0.462	7