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NOS2 [cytosol]
Stable Identifier
R-HSA-202107
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Nitric oxide synthase, inducible, iNOS
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Nitric oxide stimulates guanylate cyclase (Homo sapiens)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Homo sapiens)
NOS1,2,3 [cytosol] (Homo sapiens)
NOS2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated cytosolic proteins (Homo sapiens)
STAT3-upregulated cytosolic proteins [cytosol] (Homo sapiens)
NOS2 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
ROS and RNS production in phagocytes (Homo sapiens)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Homo sapiens)
NOS1,2,3 [cytosol] (Homo sapiens)
NOS2 [cytosol] (Homo sapiens)
Protein localization (Homo sapiens)
Peroxisomal protein import (Homo sapiens)
Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Homo sapiens)
PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:Cargo protein [cytosol] (Homo sapiens)
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
NOS2 [cytosol] (Homo sapiens)
PEX5S,L binds cargo proteins containing PTS1 (Homo sapiens)
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
NOS2 [cytosol] (Homo sapiens)
PEX5S,L:Cargo protein [cytosol] (Homo sapiens)
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
NOS2 [cytosol] (Homo sapiens)
PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)
PEX5S,L:Cargo protein [cytosol] (Homo sapiens)
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
NOS2 [cytosol] (Homo sapiens)
PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:Cargo protein [cytosol] (Homo sapiens)
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
NOS2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35228 NOS2
Gene Names
NOS2, NOS2A
Chain
chain:1-1153
Reference Genes
BioGPS Gene:4843 NOS2
COSMIC (genes):NOS2 NOS2
CTD Gene:4843 NOS2
dbSNP Gene:4843 NOS2
ENSEMBL:ENSG00000007171 NOS2
ENSEMBL_homo_sapiens_GENE:ENSG00000007171.19 NOS2
HGNC:7873 NOS2
KEGG Gene (Homo sapiens):4843 NOS2
Monarch:4843 NOS2
NCBI Gene:4843 NOS2
OMIM:163730 NOS2
UCSC:P35228 NOS2
Reference Transcript
RefSeq:XM_011524859.2 NOS2
RefSeq:NM_000625.4 NOS2
Other Identifiers
11724403_at
11752035_a_at
11752213_a_at
1418_at
1419_g_at
16842517
1948_f_at
210037_PM_s_at
210037_s_at
2576342
3714422
3714424
3748390
3748392
3750338
3750346
3750376
3750377
3750378
3750379
3750380
3750381
3750382
3750383
3750384
3750385
3750386
3750388
3750391
3750393
3750396
3750397
3750398
3750399
3750401
3750403
3750404
3750405
3750406
3750407
3750409
3750410
3750411
3750412
3750413
3750415
3750416
3750417
3750418
3750421
3750422
3750423
4843
8013536
A_23_P502464
D29675_at
D29675_s_at
GE61880
GO:0001666
GO:0001912
GO:0002227
GO:0002376
GO:0003013
GO:0003824
GO:0004517
GO:0005515
GO:0005516
GO:0005634
GO:0005654
GO:0005737
GO:0005777
GO:0005782
GO:0005829
GO:0005856
GO:0005886
GO:0006091
GO:0006520
GO:0006527
GO:0006801
GO:0006809
GO:0006954
GO:0007263
GO:0007623
GO:0009617
GO:0009725
GO:0010181
GO:0010629
GO:0012501
GO:0016491
GO:0018119
GO:0020037
GO:0023052
GO:0030163
GO:0030863
GO:0032310
GO:0032496
GO:0032755
GO:0032757
GO:0034617
GO:0034618
GO:0036211
GO:0042127
GO:0042177
GO:0042742
GO:0042803
GO:0043226
GO:0043457
GO:0045454
GO:0045776
GO:0046872
GO:0048471
GO:0050660
GO:0050661
GO:0050796
GO:0050829
GO:0051712
GO:0071222
GO:0071346
GO:0071466
GO:0098542
GO:1900015
HMNXSV003026794
HMNXSV003051116
ILMN_1747882
ILMN_1748765
ILMN_2322831
PH_hs_0027962
TC17002562.hg
TC17002894.hg
X85781_s_at
g404048_3p_a_at
Participates
as a member of
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
STAT3-upregulated cytosolic proteins [cytosol] (Homo sapiens)
NOS1,2,3 [cytosol] (Homo sapiens)
Other forms of this molecule
NOS2 [peroxisomal matrix]
NOS2 [nucleoplasm]
Inferred To
NOS2 [cytosol]
(Bos taurus)
NOS2 [cytosol]
(Canis familiaris)
NOS2 [cytosol]
(Danio rerio)
NOS2 [cytosol]
(Dictyostelium discoideum)
NOS2 [cytosol]
(Drosophila melanogaster)
NOS2 [cytosol]
(Gallus gallus)
NOS2 [cytosol]
(Mus musculus)
NOS2 [cytosol]
(Plasmodium falciparum)
NOS2 [cytosol]
(Rattus norvegicus)
NOS2 [cytosol]
(Saccharomyces cerevisiae)
NOS2 [cytosol]
(Schizosaccharomyces pombe)
NOS2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_011523161.1
,
NP_000616.3
Guide to Pharmacology - Targets
1250
OpenTargets
ENSG00000007171
IntEnz
1.14.13.39
HPA
ENSG00000007171-NOS2
GeneCards
P35228
Ensembl
ENSP00000327251
,
ENST00000313735
,
ENSG00000007171
ZINC target
P35228
PRO
P35228
Pharos - Targets
P35228
HMDB Protein
HMDBP00926
PDB
2LL6
,
3EJ8
,
3E7G
,
4NOS
,
1NSI
,
2NSI
,
5TP6
,
6JWM
,
6KEY
,
6JWN
,
4CX7
,
3HR4
,
5XN3
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04406 GAPDH
1
GAPDH [cytosol]
(R-HSA-70428)
0.499
8
UniProt:P05109 S100A8
3
S100A8 [secretory granule lumen]
(R-HSA-6804772)
S100A8 [cytosol]
(R-HSA-9626834)
S100A8 [extracellular region]
(R-HSA-5432846)
0.462
4
UniProt:P06702 S100A9
3
S100A9 [secretory granule lumen]
(R-HSA-6804774)
S100A9 [cytosol]
(R-HSA-9626869)
S100A9 [extracellular region]
(R-HSA-5432857)
0.462
7
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