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EZH2 [nucleoplasm]
Stable Identifier
R-HSA-212298
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
KMT6
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
E2F1/2/3 stimulates EZH2 transcription (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
Formation of PRC2-EZH2 complex (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Activation of HOX genes during differentiation (Homo sapiens)
Activation of anterior HOX genes in hindbrain development during early embryogenesis (Homo sapiens)
HOXA2 chromatin is activated (Homo sapiens)
HOXA2 bivalent chromatin [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
HOXA3 chromatin is activated (Homo sapiens)
HOXA3 bivalent chromatin [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
HOXB2 chromatin is activated (Homo sapiens)
HOXB2 bivalent chromatin [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
HOXB3 chromatin is activated (Homo sapiens)
HOXB3 bivalent chromatin [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
HOXC4 chromatin is activated (Homo sapiens)
HOXC4 bivalent chromatin [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
HOXD1 chromatin is activated (Homo sapiens)
HOXD1 bivalent chromatin [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
HOXD3 chromatin is activated (Homo sapiens)
HOXD3 bivalent chromatin [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXA1 chromatin (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
RARA,G:RXRA at HOXA1 bivalent chromatin [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXA4 chromatin (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
RARA,B:RXRA at HOXA4 bivalent chromatin [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXB1 chromatin (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
RARA,G:RXRA at HOXB1 bivalent chromatin [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXB4 chromatin (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
RARA,B:RXRA at HOXB4 bivalent chromatin [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXD4 chromatin (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
RARA,B:RXRA at HOXD4 bivalent chromatin [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective pyroptosis (Homo sapiens)
The GSDME gene promoter is hypermethylated (Homo sapiens)
DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Homo sapiens)
PRC2 Core:Chromatin [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Early Events (Homo sapiens)
Activation of Latent HCMV Genome (Homo sapiens)
Latent Transcriptionally Repressed HCMV Genome [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
Latent Transcriptinally Repressed HCMV Genome (Homo sapiens)
Latent Transcriptionally Repressed HCMV Genome [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
PRC2 methylates histones and DNA (Homo sapiens)
DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Homo sapiens)
DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3) [nucleoplasm] (Homo sapiens)
PRC2:Chromatin (5-methylcytosine, H3K27me3) [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Homo sapiens)
PRC2 Core:Chromatin [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 recruits DNA methyltransferases (Homo sapiens)
DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Homo sapiens)
PRC2 Core:Chromatin [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 Core:Chromatin [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 trimethylates histone H3 at lysine-27 (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2:Chromatin (H3K27me3) [nucleoplasm] (Homo sapiens)
PRC2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2:JARID2:MTF2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2:PHF1 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2:PHF19 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2:Chromatin [nucleoplasm] (Homo sapiens)
PRC2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2:JARID2:MTF2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2:PHF1 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2:PHF19 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Homo sapiens)
PRC2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2:JARID2:MTF2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2:PHF1 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2:PHF19 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2:Chromatin [nucleoplasm] (Homo sapiens)
PRC2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2:JARID2:MTF2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2:PHF1 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2:PHF19 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
E2F6:TFDP1:EPC1 binds the PRC2 complex (Homo sapiens)
E2F6:TFDP1:EPC1:PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15910 EZH2
Gene Names
EZH2, KMT6
Chain
chain:1-746
Reference Genes
BioGPS Gene:2146 EZH2
COSMIC (genes):EZH2 EZH2
CTD Gene:2146 EZH2
dbSNP Gene:2146 EZH2
ENSEMBL:ENSG00000106462 EZH2
ENSEMBL_homo_sapiens_GENE:ENSG00000106462.12 EZH2
HGNC:3527 EZH2
KEGG Gene (Homo sapiens):2146 EZH2
Monarch:2146 EZH2
NCBI Gene:2146 EZH2
OMIM:601573 EZH2
UCSC:Q15910 EZH2
Reference Transcript
RefSeq:XM_011515884.2 EZH2
RefSeq:NM_152998.2 EZH2
RefSeq:NM_001203247.1 EZH2
RefSeq:NM_004456.4 EZH2
RefSeq:NM_001203249.1 EZH2
RefSeq:NM_001203248.1 EZH2
Other Identifiers
11717657_a_at
11748690_a_at
17064105
203358_PM_s_at
203358_s_at
2146
3078349
3078350
3078352
3078353
3078356
3078358
3078360
3078362
3078364
3078369
3078371
3078374
3078377
3078382
3078383
3078384
3078385
3078386
3078391
3078392
3078393
3078399
3078400
3078401
37305_at
3919611
3930675
8143663
A_23_P259641
A_33_P3252196
GE59277
GO:0000082
GO:0000122
GO:0000278
GO:0000781
GO:0000785
GO:0000976
GO:0000978
GO:0000979
GO:0001222
GO:0001932
GO:0002376
GO:0003012
GO:0003677
GO:0003682
GO:0003714
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005677
GO:0005694
GO:0005721
GO:0006306
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0006954
GO:0008168
GO:0008284
GO:0009913
GO:0010468
GO:0010629
GO:0010718
GO:0014013
GO:0014834
GO:0014898
GO:0016279
GO:0016570
GO:0016740
GO:0018024
GO:0021695
GO:0021766
GO:0023052
GO:0030097
GO:0030154
GO:0030183
GO:0030216
GO:0031490
GO:0031507
GO:0031509
GO:0032200
GO:0032259
GO:0032355
GO:0034244
GO:0035098
GO:0035984
GO:0036211
GO:0036333
GO:0042054
GO:0042127
GO:0042752
GO:0043021
GO:0043226
GO:0043406
GO:0043433
GO:0043547
GO:0043565
GO:0045120
GO:0045202
GO:0045605
GO:0045617
GO:0045814
GO:0045892
GO:0046976
GO:0048387
GO:0048511
GO:0048856
GO:0048863
GO:0050767
GO:0051154
GO:0051932
GO:0070301
GO:0070314
GO:0070734
GO:0070878
GO:0071168
GO:0071902
GO:0090183
GO:0097421
GO:0098532
GO:0106222
GO:0140096
GO:0140110
GO:0140718
GO:0140951
GO:1900006
GO:1900016
GO:1902808
GO:1904772
GO:1990841
GO:2000134
GO:2000737
HMNXSV003004831
ILMN_1652913
ILMN_1708105
ILMN_2364529
PH_hs_0025941
TC07001993.hg
U61145_at
g4758323_3p_a_at
Participates
as an output of
E2F1/2/3 stimulates EZH2 transcription (Homo sapiens)
as an input of
Formation of PRC2-EZH2 complex (Homo sapiens)
as a component of
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
Inferred To
EZH2 [nucleoplasm]
(Bos taurus)
EZH2 [nucleoplasm]
(Canis familiaris)
EZH2 [nucleoplasm]
(Gallus gallus)
EZH2 [nucleoplasm]
(Sus scrofa)
ezh2 [nucleoplasm]
(Danio rerio)
ezh2 [nucleoplasm]
(Xenopus tropicalis)
Ezh2 [nucleoplasm]
(Mus musculus)
Ezh2 [nucleoplasm]
(Rattus norvegicus)
mes-2 [nucleoplasm]
(Caenorhabditis elegans)
E(z) [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001190176.1
,
NP_004447.2
,
XP_011514186.1
,
NP_694543.1
,
NP_001190178.1
,
NP_001190177.1
Guide to Pharmacology - Targets
2654
OpenTargets
ENSG00000106462
ZINC - Substances
EZH2_HUMAN
ZINC target
Q15910
PRO
Q15910
PDB
5LS6
,
6C23
,
7QJU
,
5WG6
,
7QK4
,
4MI0
,
5H19
,
5HYN
,
5GSA
,
7AT8
,
6WKR
,
7QJG
,
6LO2
,
5H25
,
5H15
,
6P5L
,
5H17
,
5U62
,
5IJ8
,
6C24
,
6U4Y
,
5WUK
,
5IJ7
,
5U5T
,
5H24
,
5H14
,
4MI5
ZINC - Investigational
EZH2_HUMAN
GeneCards
Q15910
HPA
ENSG00000106462-EZH2
Ensembl
ENST00000478654
,
ENSP00000419050
,
ENST00000320356
,
ENSP00000417062
,
ENST00000476773
,
ENST00000483967
,
ENST00000460911
,
ENST00000350995
,
ENSG00000106462
,
ENSP00000419856
,
ENSP00000419711
,
ENSP00000223193
,
ENSP00000320147
Pharos - Targets
Q15910
Orphanet
20793
ZINC - Predictions - Purchasable
EZH2_HUMAN
HMDB Protein
HMDBP09013
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15022 SUZ12
2
SUZ12 [nucleoplasm]
(R-HSA-212217)
monoSUMO1-K75-SUZ12 [nucleoplasm]
(R-HSA-4615932)
0.949
27
UniProt:O75530 EED
1
EED [nucleoplasm]
(R-HSA-212278)
0.914
15
UniProt:O43189 PHF1
1
PHF1 [nucleoplasm]
(R-HSA-5084105)
0.854
7
UniProt:Q9UBC3 DNMT3B
2
SUMO1-K-DNMT3B [nucleoplasm]
(R-HSA-4655334)
DNMT3B [nucleoplasm]
(R-HSA-212316)
0.834
14
UniProt:Q6ZN18 AEBP2
1
AEBP2 [nucleoplasm]
(R-HSA-5082342)
0.731
6
UniProt:Q96JN0 LCOR
0.725
5
UniProt:Q92833 JARID2
1
JARID2 [nucleoplasm]
(R-HSA-2160949)
0.725
5
UniProt:P26358 DNMT1
2
monoSUMO1-K-DNMT1 [nucleoplasm]
(R-HSA-4655353)
DNMT1 [nucleoplasm]
(R-HSA-212181)
0.693
8
UniProt:Q9Y6K1 DNMT3A
2
monoSUMO1-K-DNMT3A [nucleoplasm]
(R-HSA-4655415)
DNMT3A [nucleoplasm]
(R-HSA-212287)
0.677
6
UniProt:Q96MT8 CEP63
1
CEP63 [cytosol]
(R-HSA-380267)
0.666
4
UniProt:Q5T6S3 PHF19
1
PHF19 [nucleoplasm]
(R-HSA-5084115)
0.643
4
UniProt:Q9Y483 MTF2
1
MTF2 [nucleoplasm]
(R-HSA-5084119)
0.643
4
UniProt:A6NHQ4 EPOP
0.643
4
UniProt:Q16576 RBBP7
1
RBBP7 [nucleoplasm]
(R-HSA-212227)
0.643
4
UniProt:Q13620 CUL4B
2
CUL4B [nucleoplasm]
(R-HSA-975973)
G76-NEDD8-K859-CUL4B [nucleoplasm]
(R-HSA-8952522)
0.597
15
UniProt:P84243 H3-3A
17
MeK-H3F3A [nucleoplasm]
(R-HSA-427369)
2xAcK-H3F3A [nucleoplasm]
(R-HSA-427504)
MeK28-H3-3A [nucleoplasm]
(R-HSA-9822942)
H3R17me2a [nucleoplasm]
(R-HSA-9822613)
H3F3A [extracellular region]
(R-HSA-977567)
p-T12-H3F3A [nucleoplasm]
(R-HSA-5625878)
p-T12,MeK-H3F3A [nucleoplasm]
(R-HSA-5625858)
p-T12, Me2K-10-H3F3A [nucleoplasm]
(R-HSA-5625800)
p-T12,Me3K-10-H3F3A [nucleoplasm]
(R-HSA-5625758)
Me3K-10-H3F3A [nucleoplasm]
(R-HSA-5625747)
AcK10-H3F3A [nucleoplasm]
(R-HSA-5250654)
Me2K5,Me2aR2-H3F3A [nucleoplasm]
(R-HSA-8936573)
Me2K-10-H3F3A [nucleoplasm]
(R-HSA-427324)
Me3K5-H3F3A [nucleoplasm]
(R-HSA-1214216)
Me3K-28-H3F3A [nucleoplasm]
(R-HSA-212282)
H3F3A [nucleoplasm]
(R-HSA-212295)
Me2K5-H3F3A [nucleoplasm]
(R-HSA-1214206)
0.597
7
UniProt:Q15156 Q15156
0.576
8
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [cytosol]
(R-HSA-5618082)
AR [nucleoplasm]
(R-HSA-446174)
0.564
2
UniProt:Q8IXJ9 ASXL1
1
ASXL1 [nucleoplasm]
(R-HSA-5689645)
0.558
6
UniProt:Q92833-1 JARID2
0.558
7
UniProt:P35226 BMI1
3
BMI1 [nucleoplasm]
(R-HSA-389121)
p-S-BMI1 [nucleoplasm]
(R-HSA-3229116)
monoSUMO1-K88-BMI1 [nucleoplasm]
(R-HSA-4551729)
0.527
7
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.527
3
UniProt:P62877 RBX1
2
RBX1 [nucleoplasm]
(R-HSA-1234142)
RBX1 [cytosol]
(R-HSA-180582)
0.527
4
UniProt:P46100 ATRX
20
ATRX E288* [nucleoplasm]
(R-HSA-9670958)
ATRX K329Ifs*3 [nucleoplasm]
(R-HSA-9672232)
ATRX Q176* [nucleoplasm]
(R-HSA-9671592)
ATRX C268Qfs*18 [nucleoplasm]
(R-HSA-9672233)
ATRX Q177* [nucleoplasm]
(R-HSA-9671589)
ATRX K330Nfs*2 [nucleoplasm]
(R-HSA-9672231)
ATRX G161* [nucleoplasm]
(R-HSA-9671266)
ATRX Q176Hfs*13 [nucleoplasm]
(R-HSA-9671806)
ATRX R160Pfs*29 [nucleoplasm]
(R-HSA-9671801)
ATRX K319* [nucleoplasm]
(R-HSA-9671669)
ATRX W222* [nucleoplasm]
(R-HSA-9671670)
ATRX E63* [nucleoplasm]
(R-HSA-9670961)
ATRX S79* [nucleoplasm]
(R-HSA-9671244)
ATRX H166Mfs*4 [nucleoplasm]
(R-HSA-9672205)
ATRX Y266* [nucleoplasm]
(R-HSA-9671624)
ATRX L253* [nucleoplasm]
(R-HSA-9671688)
ATRX W263* [nucleoplasm]
(R-HSA-9671685)
ATRX Y187* [nucleoplasm]
(R-HSA-9671622)
ATRX Y204* [nucleoplasm]
(R-HSA-9671619)
ATRX Q292* [nucleoplasm]
(R-HSA-9671581)
0.524
2
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.508
2
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.499
5
UniProt:Q9CWR8 Dnmt3l
1
Dnmt3l [nucleoplasm]
(R-MMU-5334127)
0.499
2
UniProt:A4PIW0 A4PIW0
0.462
5
IntAct:EBI-1265559 MYC
0.462
2
IntAct:EBI-5276484 ACTB
0.462
2
UniProt:Q16531 DDB1
1
DDB1 [nucleoplasm]
(R-HSA-53489)
0.462
10
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.462
2
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