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KLK3 [extracellular region]
Stable Identifier
R-HSA-381416
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Prostate Specific Antigen, KLK3_HUMAN, PSA
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
Prostate Specific Antigen [extracellular region] (Homo sapiens)
KLK3 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
PKN1 in complex with AR positively regulates expression of KLK2 and KLK3 (Homo sapiens)
KLK2,KLK3 [extracellular region] (Homo sapiens)
KLK3 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07288 KLK3
Gene Names
KLK3, APS
Chain
signal peptide:1-17, propeptide:18-24, chain:25-261
Reference Genes
BioGPS Gene:354 KLK3
COSMIC (genes):KLK3 KLK3
CTD Gene:354 KLK3
dbSNP Gene:354 KLK3
ENSEMBL:ENSG00000142515 KLK3
HGNC:6364 KLK3
KEGG:hsa:354 KLK3
Monarch:354 KLK3
NCBI Gene:354 KLK3
OMIM:176820 KLK3
UCSC:P07288 KLK3
Reference Transcript
RefSeq:NM_001030048.1 KLK3
RefSeq:NM_001648.2 KLK3
RefSeq:NM_001030047.1 KLK3
Other Identifiers
11740321_a_at
11740322_at
11741021_x_at
11741307_a_at
11743956_a_at
11745753_x_at
11755731_a_at
1513_at
1514_g_at
1661_i_at
1662_r_at
16864616
1804_at
1805_g_at
204582_PM_s_at
204582_s_at
204583_PM_x_at
204583_x_at
354
3839539
3839540
3839541
3839542
3839543
3839544
3839545
3839546
3839547
3839548
3839549
3839550
3839551
3839552
3839553
3839554
3839555
3839556
3839557
3839558
3839559
3839560
3839562
3839581
40794_at
69598_at
76108_at
8030753
89468_at
A_14_P108963
A_14_P137892
A_23_P334538
A_24_P108401
A_24_P344510
A_33_P3215838
A_33_P3215843
GE79325
GE85191
GO:0002803
GO:0003824
GO:0004175
GO:0004252
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0006508
GO:0008236
GO:0016525
GO:0016787
GO:0016811
GO:0030141
GO:0031410
GO:0032991
GO:0043226
GO:0070062
GO:0140096
HMNXSV003014446
HMNXSV003015360
HMNXSV003035426
HMNXSV003038817
ILMN_1655426
ILMN_1663787
ILMN_1748981
PH_hs_0010302
PH_hs_0031989
TC19000770.hg
TC19002207.hg
X07730_at
g4502172_3p_a_at
g595945_3p_a_at
Participates
as a member of
Prostate Specific Antigen [extracellular region] (Homo sapiens)
KLK2,KLK3 [extracellular region] (Homo sapiens)
Inferred To
ENSRNOG00000066972 [extracellular region]
(Rattus norvegicus)
Klk7 [extracellular region]
(Rattus norvegicus)
ENSRNOG00000067174 [extracellular region]
(Rattus norvegicus)
ENSRNOG00000069479 [extracellular region]
(Rattus norvegicus)
Homologues of KLK3 [extracellular region]
(Rattus norvegicus)
Klk12 [extracellular region]
(Rattus norvegicus)
Klk6 [extracellular region]
(Rattus norvegicus)
Klk9 [extracellular region]
(Rattus norvegicus)
Klk1c4 [extracellular region]
(Rattus norvegicus)
Ngfg [extracellular region]
(Rattus norvegicus)
Klk10 [extracellular region]
(Rattus norvegicus)
Klk1c6 [extracellular region]
(Rattus norvegicus)
ENSRNOG00000071144 [extracellular region]
(Rattus norvegicus)
KLK3 [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_001639.1
,
NP_001025219.1
,
NP_001025218.1
Guide to Pharmacology - Targets
2373
ENSEMBL
ENSP00000471155
,
ENST00000326003
,
ENSP00000314151
,
ENSP00000353829
,
ENST00000595952
,
ENSP00000472907
,
ENST00000360617
,
ENST00000593997
OpenTargets
ENSG00000142515
ZINC - Substances
KLK3_HUMAN
ZINC target
P07288
PRO
P07288
GlyGen
P07288
PDB
3QUM
,
2ZCH
,
2ZCK
,
2ZCL
IntEnz
3.4.21.77
HPA
ENSG00000142515-KLK3
Pharos - Targets
P07288
ZINC - Predictions - Purchasable
KLK3_HUMAN
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10275 AR
4
AR [cytosol]
(R-HSA-5618082)
AR [nucleoplasm]
(R-HSA-446174)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
0.604
3
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