Reactome | PRKAB1 [nucleoplasm]

PRKAB1 [nucleoplasm]

Stable Identifier

R-HSA-2151199

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

AMPK beta1, 5'-AMP-activated protein kinase subunit beta-1, AAKB1_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        AMPK phosphorylates TP53 (Homo sapiens)
        
        Activated AMPK heterotrimer [nucleoplasm] (Homo sapiens)
        
        AMPK beta [nucleoplasm] (Homo sapiens)
        
        PRKAB1 [nucleoplasm] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Activation of PPARGC1A (PGC-1alpha) by phosphorylation (Homo sapiens)
    - AMPK phosphorylates PPARGC1A (Homo sapiens)
      - p-AMPK heterotrimer:AMP [nucleoplasm] (Homo sapiens)
        
        p-AMPK heterotrimer [nucleoplasm] (Homo sapiens)
        
        AMPK beta [nucleoplasm] (Homo sapiens)
        
        PRKAB1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y478 PRKAB1

Gene Names

PRKAB1, AMPK

Chain

initiator methionine:, chain:2-270

Reference Genes

BioGPS Gene:5564 PRKAB1

COSMIC (genes):PRKAB1 PRKAB1

CTD Gene:5564 PRKAB1

dbSNP Gene:5564 PRKAB1

ENSEMBL:ENSG00000111725 PRKAB1

HGNC:9378 PRKAB1

KEGG:hsa:5564 PRKAB1

Monarch:5564 PRKAB1

NCBI Gene:5564 PRKAB1

OMIM:602740 PRKAB1

UCSC:Q9Y478 PRKAB1

Reference Transcript

Other Identifiers

11716217_a_at

11716218_s_at

11751635_a_at

16757806

201834_PM_at

201834_at

201835_PM_s_at

201835_s_at

3434144

3434145

3434146

3434147

3434148

3434149

3434150

3434151

3434152

3434153

3434155

3434156

3434157

3434158

3434159

35348_at

5564

7959123

A_14_P116465

A_23_P204503

GE54167

GO:0003824

GO:0004672

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006468

GO:0006629

GO:0006633

GO:0007165

GO:0010628

GO:0016740

GO:0019901

GO:0031588

GO:0031669

GO:0032991

GO:0035878

GO:0043226

GO:0048856

GO:0120162

GO:0140096

HMNXSV003025719

ILMN_1793522

PH_hs_0028730

TC12000936.hg

Y12556_at

g12654368_3p_at

g5453967_3p_a_at

Participates

as a member of

AMPK beta [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PRKAB1 [cytosol]

Inferred To

prkab1a [nucleoplasm] (Danio rerio)

alc [nucleoplasm] (Drosophila melanogaster)

PRKAB1 [nucleoplasm] (Bos taurus)

PRKAB1 [nucleoplasm] (Canis familiaris)

PRKAB1 [nucleoplasm] (Sus scrofa)

Prkab1 [nucleoplasm] (Mus musculus)

Prkab1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_006244.2, XP_005253966.1

Guide to Pharmacology - Targets

1543

OpenTargets

ENSG00000111725

ENSEMBL

ENSP00000441369, ENST00000541640, ENSP00000229328, ENST00000229328

HPA

ENSG00000111725-PRKAB1

ZINC target

Q9Y478

PRO

Q9Y478

Pharos - Targets

Q9Y478

PDB

6C9G, 6C9F, 5ISO, 5EZV, 6B1U, 4CFE, 4ZHX, 6C9J, 6C9H, 4CFF, 7MYJ, 8BIK

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.845	10
UniProt:O75385 ULK1	7	ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-S758-ULK1 [cytosol] (R-HSA-5672131) ULK1 [recycling endosome] (R-HSA-8854761)	0.641	3
UniProt:P16152 CBR1	1	CBR1 [cytosol] (R-HSA-2142784)	0.564	2
UniProt:O70302 Cidea	2	Cidea [cytosol] (R-MMU-9855021) Cidea [cytosol] (R-MMU-8856626)	0.556	4
UniProt:Q8IYL2 TRMT44	1	TRMT44 [cytosol] (R-HSA-6788685)	0.527	2
UniProt:P49590 HARS2	1	HARS2 [mitochondrial matrix] (R-HSA-379581)	0.527	2
UniProt:P32239 CCKBR	1	CCKBR [plasma membrane] (R-HSA-388515)	0.527	2
UniProt:Q07820 MCL1	1	MCL1 [cytosol] (R-HSA-5661490)	0.527	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.508	2