Reactome | MAP1LC3C(1-147) [cytosol]

MAP1LC3C(1-147) [cytosol]

Stable Identifier

R-HSA-5682653

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Microtubule-associated proteins 1A/1B light chain 3C, MLP3C_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BXW4 MAP1LC3C

Gene Names

MAP1LC3C

Chain

chain:1-126, propeptide:127-147

Reference Genes

BioGPS Gene:440738 MAP1LC3C

COSMIC (genes):MAP1LC3C MAP1LC3C

CTD Gene:440738 MAP1LC3C

dbSNP Gene:440738 MAP1LC3C

ENSEMBL:ENSG00000197769.6 MAP1LC3C

HGNC:13353 MAP1LC3C

KEGG Gene (Homo sapiens):440738 MAP1LC3C

Monarch:440738 MAP1LC3C

NCBI Gene:440738 MAP1LC3C

OMIM:609605 MAP1LC3C

UCSC:Q9BXW4 MAP1LC3C

Reference Transcript

Other Identifiers

11738432_at

11738433_at

16701110

221697_PM_at

221697_at

440738

7925504

A_24_P216456

GE79708

GO:0000045

GO:0000421

GO:0000422

GO:0005515

GO:0005737

GO:0005773

GO:0005776

GO:0005829

GO:0005856

GO:0005874

GO:0006886

GO:0006914

GO:0006995

GO:0007005

GO:0008017

GO:0008092

GO:0009267

GO:0012505

GO:0016020

GO:0016236

GO:0031090

GO:0031410

GO:0031625

GO:0032527

GO:0035973

GO:0036464

GO:0043226

GO:0097352

HMNXSV003049957

ILMN_1711331

PH_hs_0035147

TC01004028.hg

g13625772_3p_at

Participates

as a member of

LC3 family precursors [cytosol] (Homo sapiens)

Other forms of this molecule

MAP1LC3C [autophagosome membrane]

MAP1LC3C [cytosol]

Inferred To

MAP1-LC3C [cytosol] (Danio rerio)

MAP1LC3C [cytosol] (Bos taurus)

MAP1LC3C [cytosol] (Sus scrofa)

Homologues of MAP1LC3C(1-147) [cytosol] (Dictyostelium discoideum)

atg8 [cytosol] (Dictyostelium discoideum)

atg8 [cytosol] (Schizosaccharomyces pombe)

LOC100496229 [cytosol] (Xenopus tropicalis)

ATG8 [cytosol] (Saccharomyces cerevisiae)

MAP1LC3C(1-147) [cytosol] (Caenorhabditis elegans)

MAP1LC3C(1-147) [cytosol] (Canis familiaris)

MAP1LC3C(1-147) [cytosol] (Dictyostelium discoideum)

MAP1LC3C(1-147) [cytosol] (Gallus gallus)

MAP1LC3C(1-147) [cytosol] (Plasmodium falciparum)

Cross References

RefSeq

XP_005273196.1, NP_001004343.1

OpenTargets

ENSG00000197769

HPA

ENSG00000197769-MAP1LC3C

GeneCards

Q9BXW4

Ensembl

ENSG00000197769, ENSP00000349785, ENST00000357246

PRO

Q9BXW4

Pharos - Targets

Q9BXW4

PDB

3WAM, 3WAP, 3VVW, 5DPW, 2NCN

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.862	7
UniProt:Q14596 NBR1	2	NBR1 [peroxisomal membrane] (R-HSA-9665177) NBR1 [cytosol] (R-HSA-9665180)	0.676	3
UniProt:O75385 ULK1	7	ULK1 [recycling endosome] (R-HSA-8854761) p-S758-ULK1 [cytosol] (R-HSA-5672131) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858)	0.656	3
UniProt:Q3MII6 TBC1D25	1	TBC1D25 [autophagosome] (R-HSA-8854607)	0.556	3
UniProt:O43561-2 LAT	2	p-5Y-LAT-2 [plasma membrane] (R-HSA-2396597) LAT-2 [plasma membrane] (R-HSA-2396548)	0.556	3
UniProt:Q96A56 TP53INP1	1	TP53INP1 [nucleoplasm] (R-HSA-3215226)	0.556	3
UniProt:Q13188 STK3	4	p-T180-STK3(1-322) [cytosol] (R-HSA-2028696) STK3(323-491) [cytosol] (R-HSA-2028684) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) STK3(1-491) [cytosol] (R-HSA-2028280)	0.544	2
UniProt:O00410 IPO5	1	IPO5 [nucleoplasm] (R-HSA-192675)	0.544	2
UniProt:Q676U5 ATG16L1	1	ATG16L1 [cytosol] (R-HSA-5671734)	0.525	4

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