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NEIL3 [nucleoplasm]
Stable Identifier
R-HSA-9629184
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Endonuclease 8-like 3 ecNumber3.2.2.-/ecNumber ecNumber4.2.99.18/ecNumber, NEIL3_HUMAN, DNA glycosylase FPG2, DNA glycosylase/AP lyase Neil3, Endonuclease VIII-like 3, Nei-like protein 3
Icon
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Base-Excision Repair, AP Site Formation (Homo sapiens)
Depurination (Homo sapiens)
Cleavage of the damaged purine (Homo sapiens)
NEIL3 cleaves 5-guanidinohydantoin (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:AP-DNA [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:Gh-DNA [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3 cleaves spiroiminodihydantoin (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:AP-DNA [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:Sp-DNA [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected purine (Homo sapiens)
NEIL3 recognizes and binds to 5-guanidinohydantoin (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:Gh-DNA [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3 recognizes and binds to spiroiminodihydantoin (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:Sp-DNA [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3 recognizes and binds to spiroiminodihydantoin in telomeric DNA (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
Depyrimidination (Homo sapiens)
Cleavage of the damaged pyrimidine (Homo sapiens)
NEIL3 cleaves thymine glycol (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:AP-DNA [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:Tg-DNA [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3 cleaves thymine glycol from telomeric DNA (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Homo sapiens)
NEIL3 recognizes and binds to thymine glycol (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:Tg-DNA [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3 recognizes and binds to thymine glycol in telomeric DNA (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3:Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3-mediated resolution of ICLs (Homo sapiens)
NEIL3 resolves abasic site-induced ICLs (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
NEIL3 resolves psoralen-induced ICLs (Homo sapiens)
NEIL3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TAT5 NEIL3
Gene Names
NEIL3
Chain
initiator methionine:, chain:2-605
Reference Genes
BioGPS Gene:55247 NEIL3
COSMIC (genes):NEIL3 NEIL3
CTD Gene:55247 NEIL3
dbSNP Gene:55247 NEIL3
ENSEMBL:ENSG00000109674 NEIL3
HGNC:24573 NEIL3
Monarch:55247 NEIL3
NCBI Gene:55247 NEIL3
OMIM:608934 NEIL3
UCSC:Q8TAT5 NEIL3
Reference Transcript
RefSeq:NM_018248.2 NEIL3
Other Identifiers
11740012_a_at
11740013_at
16972616
219502_PM_at
219502_at
2752728
2752729
2752730
2752731
2752732
2752735
2752736
2752740
2752741
2752746
2752747
2752749
2752750
2752751
2752752
2752753
2752754
55247
8098423
82239_at
A_14_P135128
GE55888
GO:0000012
GO:0000405
GO:0003676
GO:0003677
GO:0003684
GO:0003690
GO:0003697
GO:0003824
GO:0003906
GO:0005634
GO:0005654
GO:0005694
GO:0006281
GO:0006284
GO:0006285
GO:0008270
GO:0016787
GO:0016798
GO:0016799
GO:0016829
GO:0019104
GO:0036297
GO:0043226
GO:0045007
GO:0046872
GO:0140078
GO:0140097
GO:1904931
HMNXSV003013450
ILMN_1757697
ILMN_2114747
PH_hs_0024652
TC04000874.hg
g8922721_3p_at
Participates
as an input of
NEIL3 recognizes and binds to thymine glycol in telomeric DNA (Homo sapiens)
NEIL3 recognizes and binds to thymine glycol (Homo sapiens)
NEIL3 recognizes and binds to spiroiminodihydantoin in telomeric DNA (Homo sapiens)
NEIL3 recognizes and binds to spiroiminodihydantoin (Homo sapiens)
NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Homo sapiens)
NEIL3 recognizes and binds to 5-guanidinohydantoin (Homo sapiens)
as a component of
NEIL3:Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
NEIL3:Tg-DNA [nucleoplasm] (Homo sapiens)
NEIL3:Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
NEIL3:Sp-DNA [nucleoplasm] (Homo sapiens)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
NEIL3:AP-DNA [nucleoplasm] (Homo sapiens)
NEIL3:Gh-DNA [nucleoplasm] (Homo sapiens)
Other forms of this molecule
NEIL3 D132V [nucleoplasm]
Inferred To
Neil3 [nucleoplasm]
(Rattus norvegicus)
NEIL3 [nucleoplasm]
(Bos taurus)
NEIL3 [nucleoplasm]
(Canis familiaris)
NEIL3 [nucleoplasm]
(Gallus gallus)
NEIL3 [nucleoplasm]
(Mus musculus)
NEIL3 [nucleoplasm]
(Sus scrofa)
neil3 [nucleoplasm]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENST00000264596
,
ENSP00000264596
OpenTargets
ENSG00000109674
HPA
ENSG00000109674-NEIL3
PRO
Q8TAT5
Pharos - Targets
Q8TAT5
GlyGen
Q8TAT5
HMDB Protein
HMDBP13642
PDB
7TMY
,
7JL5
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15185 PTGES3
2
PTGES3 [nucleoplasm]
(R-HSA-5082403)
PTGES3 [cytosol]
(R-HSA-265269)
0.527
3
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