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RTEL1 [nucleoplasm]
Stable Identifier
R-HSA-5686112
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Regulator of telomere elongation helicase 1, NHL
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere Extension By Telomerase (Homo sapiens)
Alignment Of The RNA Template On The Telomeric Chromosome End (Homo sapiens)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Homo sapiens)
RTEL1 [nucleoplasm] (Homo sapiens)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Homo sapiens)
RTEL1 [nucleoplasm] (Homo sapiens)
Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)
RTEL1 [nucleoplasm] (Homo sapiens)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Homo sapiens)
RTEL1 [nucleoplasm] (Homo sapiens)
Elongation Of The Telomeric Chromosome End (Homo sapiens)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Homo sapiens)
RTEL1 [nucleoplasm] (Homo sapiens)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
RTEL1 [nucleoplasm] (Homo sapiens)
Elongation of Extended Telomeric Chromosome End (Homo sapiens)
Telomerase Holoenzyme Base-paired to the Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
RTEL1 [nucleoplasm] (Homo sapiens)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Homo sapiens)
RTEL1 [nucleoplasm] (Homo sapiens)
Recruitment of Telomerase RNP to the Telomeric Chromosome End (Homo sapiens)
RTEL1 [nucleoplasm] (Homo sapiens)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Homo sapiens)
RTEL1 [nucleoplasm] (Homo sapiens)
Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Homo sapiens)
Telomerase Holoenzyme Base-paired to the Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
RTEL1 [nucleoplasm] (Homo sapiens)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
RTEL1 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
Resolution of D-Loop Structures (Homo sapiens)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) (Homo sapiens)
D-loop dissociation and strand annealing (Homo sapiens)
RTEL1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NZ71 RTEL1
Gene Names
RTEL1, C20orf41, KIAA1088, NHL
Chain
chain:1-1219
Reference Genes
BioGPS Gene:51750 RTEL1
COSMIC (genes):RTEL1 RTEL1
CTD Gene:51750 RTEL1
dbSNP Gene:51750 RTEL1
ENSEMBL:ENSG00000258366 RTEL1
HGNC:15888 RTEL1
KEGG:hsa:51750 RTEL1
Monarch:51750 RTEL1
NCBI Gene:51750 RTEL1
OMIM:608833 RTEL1
UCSC:Q9NZ71 RTEL1
Reference Transcript
RefSeq:NM_032957.4 RTEL1
RefSeq:NM_001283009.1 RTEL1
RefSeq:NM_016434.3 RTEL1
RefSeq:NM_001283010.1 RTEL1
Other Identifiers
11720019_x_at
11720021_a_at
11745427_x_at
11746619_a_at
11756620_x_at
16916012
206092_PM_x_at
206092_x_at
211526_PM_s_at
211526_s_at
213829_PM_x_at
213829_x_at
216325_PM_x_at
216325_x_at
2739892
2739898
2739904
2739914
35381_at
3893523
3893524
3893525
3893526
3893527
3893528
3893530
3893531
3893532
3893533
3893534
3893535
3893536
3893537
3893538
3893539
3893540
3893541
3893543
3893545
3893546
3893548
3893549
3893550
3893551
3893552
3893554
3893555
3893556
3893557
3893558
3893559
3893560
3893561
3893562
3893565
3893566
3893567
3893568
3893569
3893570
3893571
3893572
3893573
3893574
3893575
3893576
3893577
3893578
3893579
3893580
3893581
3893582
3893584
3893585
3893586
3893587
3893588
3893589
3893590
3893591
3893592
3893593
3893594
3893597
3893598
3893599
3893600
3893601
3893602
51750
8064111
A_23_P378526
A_33_P3305571
GO:0000723
GO:0000732
GO:0000781
GO:0003676
GO:0003677
GO:0003678
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0006139
GO:0006259
GO:0006260
GO:0006281
GO:0006310
GO:0010569
GO:0016607
GO:0016787
GO:0016818
GO:0016887
GO:0031297
GO:0031965
GO:0032200
GO:0032206
GO:0032508
GO:0043226
GO:0043247
GO:0045910
GO:0046872
GO:0051539
GO:0070182
GO:0090657
GO:0140097
GO:0140640
GO:0140657
GO:1902990
GO:1904355
GO:1904358
GO:1904430
GO:1904506
GO:1904535
HMNXSV003046792
Hs.281383.2.S1_3p_s_at
ILMN_1661825
ILMN_1709538
ILMN_1778629
ILMN_1803162
ILMN_2331232
PH_hs_0035980
TC20000521.hg
TC20001358.hg
g7706540_3p_s_at
Participates
as an input of
Recruitment of Telomerase RNP to the Telomeric Chromosome End (Homo sapiens)
as a component of
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Homo sapiens)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Homo sapiens)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Telomerase Holoenzyme Base-paired to the Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Homo sapiens)
as an output of
Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)
Other forms of this molecule
RTEL1 [cytosol]
Inferred To
RTEL1 [nucleoplasm]
(Bos taurus)
RTEL1 [nucleoplasm]
(Canis familiaris)
RTEL1 [nucleoplasm]
(Gallus gallus)
RTEL1 [nucleoplasm]
(Mus musculus)
RTEL1 [nucleoplasm]
(Rattus norvegicus)
RTEL1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001269939.1
,
NP_116575.3
,
NP_001269938.1
,
NP_057518.1
ENSEMBL
ENSP00000353332
,
ENSP00000322287
,
ENST00000508582
,
ENST00000318100
,
ENST00000360203
,
ENST00000482936
,
ENST00000370018
,
ENSP00000424307
,
ENSP00000457868
,
ENSP00000359035
OpenTargets
ENSG00000258366
HPA
ENSG00000258366-RTEL1
PRO
Q9NZ71
Pharos - Targets
Q9NZ71
Orphanet
RTEL1
HMDB Protein
HMDBP11928
PDB
8YA8
,
8P8H
,
7WU8
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96T76 MMS19
1
MMS19 [cytosol]
(R-HSA-2161121)
0.641
4
UniProt:Q15185 PTGES3
2
PTGES3 [nucleoplasm]
(R-HSA-5082403)
PTGES3 [cytosol]
(R-HSA-265269)
0.527
2
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