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KIF18A [cytosol]
Stable Identifier
R-HSA-376239
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Kinesins (Homo sapiens)
Kinesin-8 is a dimer (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
KIF18A dimer [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Kinesins bind microtubules (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
KIF18A dimer [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
KIF18A dimer [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Kinesins move along microtubules consuming ATP (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
KIF18A dimer [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
KIF18A dimer [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
KIF18A dimer [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
KIF18A dimer [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
KIF18A dimer [cytosol] (Homo sapiens)
KIF18A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NI77 KIF18A
Gene Names
KIF18A, OK/SW-cl.108
Chain
chain:1-898
Reference Genes
BioGPS Gene:81930 KIF18A
COSMIC (genes):KIF18A KIF18A
CTD Gene:81930 KIF18A
dbSNP Gene:81930 KIF18A
ENSEMBL:ENSG00000121621 KIF18A
HGNC:29441 KIF18A
KEGG:hsa:81930 KIF18A
Monarch:81930 KIF18A
NCBI Gene:81930 KIF18A
OMIM:611271 KIF18A
UCSC:Q8NI77 KIF18A
Reference Transcript
RefSeq:XM_017018379.1 KIF18A
RefSeq:NM_031217.3 KIF18A
Other Identifiers
11727458_at
16736891
221258_PM_s_at
221258_s_at
3367346
3367347
3367348
3367350
3367351
3367352
3367354
3367357
3367358
3367360
3367362
3367363
3367366
3367367
3367368
3367369
3367370
3367371
3367373
3367374
3367375
3367376
3367377
76774_at
7947248
81930
A_23_P150667
A_33_P3242649
GE83216
GO:0000070
GO:0000776
GO:0001726
GO:0003774
GO:0003777
GO:0003779
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005819
GO:0005828
GO:0005829
GO:0005856
GO:0005871
GO:0005874
GO:0005901
GO:0007010
GO:0007018
GO:0007019
GO:0007059
GO:0007080
GO:0007140
GO:0008017
GO:0008092
GO:0008574
GO:0015031
GO:0015630
GO:0016787
GO:0016887
GO:0022414
GO:0042995
GO:0043226
GO:0048856
GO:0051010
GO:0061673
GO:0070463
GO:0070507
GO:0071392
GO:0072520
GO:0140013
GO:0140657
GO:1990023
HMNXSV003018679
ILMN_2132161
PH_hs_0015506
TC11001517.hg
g13654289_3p_s_at
Participates
as an input of
Kinesin-8 is a dimer (Homo sapiens)
as a component of
KIF18A dimer [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Inferred To
KIF18A [cytosol]
(Caenorhabditis elegans)
KIF18A [cytosol]
(Canis familiaris)
KIF18A [cytosol]
(Danio rerio)
KIF18A [cytosol]
(Dictyostelium discoideum)
KIF18A [cytosol]
(Drosophila melanogaster)
KIF18A [cytosol]
(Gallus gallus)
KIF18A [cytosol]
(Mus musculus)
KIF18A [cytosol]
(Plasmodium falciparum)
KIF18A [cytosol]
(Rattus norvegicus)
KIF18A [cytosol]
(Saccharomyces cerevisiae)
KIF18A [cytosol]
(Schizosaccharomyces pombe)
KIF18A [cytosol]
(Sus scrofa)
Ghost homologue of KIF18A [cytosol]
(Bos taurus)
Ghost homologue of KIF18A [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_112494.3
,
XP_016873868.1
ENSEMBL
ENSG00000121621
,
ENSP00000263181
,
ENST00000263181
OpenTargets
ENSG00000121621
GeneCards
KIF18A
HPA
ENSG00000121621-KIF18A
PRO
Q8NI77
Pharos - Targets
Q8NI77
GlyGen
Q8NI77
PDB
5OAM
,
5OGC
,
7RSI
,
5OCU
,
3LRE
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.794
5
UniProt:Q96EK5 KBP
0.643
4
UniProt:Q9UJX5 ANAPC4
2
ANAPC4 [cytosol]
(R-HSA-174168)
ANAPC4 [nucleoplasm]
(R-HSA-174115)
0.623
3
UniProt:Q15185 PTGES3
2
PTGES3 [nucleoplasm]
(R-HSA-5082403)
PTGES3 [cytosol]
(R-HSA-265269)
0.527
3
UniProt:P36873 PPP1CC
1
PPP1CC [cytosol]
(R-HSA-163443)
0.527
4
UniProt:P62140 PPP1CB
4
PPP1CB [cytosol]
(R-HSA-163405)
PPP1CB [nucleoplasm]
(R-HSA-62003)
PPP1CB P49R [cytosol]
(R-HSA-9660547)
PPP1CB A56P [cytosol]
(R-HSA-9660543)
0.508
2
UniProt:Q15435 PP1R7
0.508
2
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