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VPU (P05919) protein [extracellular region]
Stable Identifier
R-HIV-175522
Type
Protein [EntityWithAccessionedSequence]
Species
Human immunodeficiency virus 1
Compartment
extracellular region
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Binding and entry of HIV virion (Homo sapiens)
Binding of gp120 of ENV oligomer to the host CD4 (Homo sapiens)
Mature HIV virion [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with CD4 bound to gp120 [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4 (Homo sapiens)
Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with exposed coreceptor binding sites [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Conformational change in gp120 of Env oligomer (Homo sapiens)
Virion with CD4 bound to gp120 [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with exposed coreceptor binding sites [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Conformational changes in gp120 exposes gp41 (Homo sapiens)
Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with gp41 exposed [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Fusion of viral membrane with host cell membrane (Homo sapiens)
Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Fusogenic activation of gp41 (Homo sapiens)
Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with gp41 exposed [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Insertion of gp41 fusion peptide into the target membrane (Homo sapiens)
Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
N and C terminal heptad repeat helices of gp41 form six-helix bundle (Homo sapiens)
Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Late Phase of HIV Life Cycle (Homo sapiens)
Budding and maturation of HIV virion (Homo sapiens)
HIV Virion Budding (Homo sapiens)
Immature HIV virion [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Maturation of HIV Virion (Homo sapiens)
Immature HIV virion [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Mature HIV virion [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
External Reference Information
External Reference
UniProt:P05919 vpu
Gene Names
vpu
Chain
chain:1-82
Reference Genes
BioGPS Gene:155945 vpu
KEGG:vg:155945 vpu
Monarch:155945 vpu
NCBI Gene:155945 vpu
UCSC:P05919 vpu
Reference Transcript
RefSeq:NC_001802.1 vpu
Participates
as a component of
Immature HIV virion [extracellular region] (Homo sapiens)
Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
Mature HIV virion [extracellular region] (Homo sapiens)
Virion with CD4 bound to gp120 [extracellular region] (Homo sapiens)
Virion with exposed coreceptor binding sites [extracellular region] (Homo sapiens)
Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
Virion with gp41 exposed [extracellular region] (Homo sapiens)
Other forms of this molecule
VPU (P05919) protein [cytosol]
VPU (P05919) [endoplasmic reticulum membrane]
VPU (P05919) protein [nucleoplasm]
VPU (P05919) [Golgi membrane]
VPU (P05919) [plasma membrane]
Cross References
PDB
2N29
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.597
3
UniProt:Q13616 CUL1
3
CUL1 [cytosol]
(R-HSA-174230)
CUL1 [nucleoplasm]
(R-HSA-187551)
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
0.597
4
UniProt:P01730 CD4
4
CD4 [plasma membrane]
(R-HSA-167542)
CD4 [endoplasmic reticulum membrane]
(R-HSA-180575)
CD4 [early endosome]
(R-HSA-182147)
CD4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869082)
0.524
3
UniProt:P13598 ICAM2
1
ICAM2 [plasma membrane]
(R-HSA-197852)
0.462
2
UniProt:Q9NQC3 RTN4
1
RTN4 [plasma membrane]
(R-HSA-194556)
0.462
4
UniProt:Q63HN8 RNF213
3
RNF213(1-1172)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9715284)
RNF213(1-1172)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9715291)
RNF213 [cytosol]
(R-HSA-9635613)
0.462
2
UniProt:P42704 LRPPRC
1
LRPPRC [mitochondrial matrix]
(R-HSA-5336174)
0.462
4
UniProt:O14828 SCAM3
0.462
4
UniProt:Q9UHQ9 CYB5R1
3
CYB5R1 [plasma membrane]
(R-HSA-8848888)
CYB5R1 [platelet alpha granule membrane]
(R-HSA-8848891)
CYB5R1 [endoplasmic reticulum membrane]
(R-HSA-6806847)
0.462
4
UniProt:P63208 SKP1
2
SKP1 [cytosol]
(R-HSA-174150)
SKP1 [nucleoplasm]
(R-HSA-187538)
0.462
4
UniProt:P78357 CNTNAP1
1
CNTNAP1 [plasma membrane]
(R-HSA-373626)
0.462
2
UniProt:Q16537 PPP2R5E
1
PPP2R5E [cytosol]
(R-HSA-1638770)
0.462
2
UniProt:Q9NVI7 ATD3A
0.462
4
UniProt:P24539 ATP5PB
1
ATP5PB [mitochondrial inner membrane]
(R-HSA-164537)
0.462
2
UniProt:Q9HAV4 XPO5
2
XPO5 [cytosol]
(R-HSA-847719)
XPO5 [nucleoplasm]
(R-HSA-847721)
0.462
2
UniProt:O14980 XPO1
2
XPO1 [cytosol]
(R-HSA-165539)
XPO1 [nucleoplasm]
(R-HSA-165529)
0.462
2
UniProt:Q96P70 IPO9
0.462
4
UniProt:Q96F15 GIMA5
0.462
2
UniProt:P26038 MSN
4
MSN [cytosol]
(R-HSA-437350)
MSN(2-448)-ALK(1064-1620) fusion [cytosol]
(R-HSA-9711966)
MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol]
(R-HSA-9711971)
p-T558-MSN [cytosol]
(R-HSA-9663005)
0.462
2
UniProt:P48047 ATP5PO
1
ATP5PO [mitochondrial inner membrane]
(R-HSA-164533)
0.462
2
UniProt:Q86XR8 CEP57
1
CEP57 [cytosol]
(R-HSA-380271)
0.462
2
UniProt:P30049 ATP5F1D
1
ATP5F1D [mitochondrial matrix]
(R-HSA-164574)
0.462
2
UniProt:O95573 ACSL3
2
ACSL3 [mitochondrial outer membrane]
(R-HSA-9632656)
ACSL3 [endoplasmic reticulum membrane]
(R-HSA-548787)
0.462
2
UniProt:Q53GQ0 HSD17B12
1
HSD17B12 [endoplasmic reticulum membrane]
(R-HSA-548766)
0.462
2
UniProt:Q969Z0 TBRG4
1
TBRG4 [mitochondrial matrix]
(R-HSA-9837166)
0.462
2
UniProt:Q9Y6D6 BIG1
0.462
2
UniProt:Q9Y6D5 ARFGEF2
1
ARFGEF2 [cytosol]
(R-HSA-391301)
0.462
2
UniProt:O95197 RTN3
1
RTN3 [plasma membrane]
(R-HSA-8849907)
0.462
4
UniProt:P18859 ATP5PF
1
ATP5PF [mitochondrial inner membrane]
(R-HSA-164532)
0.462
4
UniProt:P55084 HADHB
1
HADHB [mitochondrial inner membrane]
(R-HSA-77266)
0.462
4
UniProt:Q5T9A4 ATAD3B
3
ATAD3B [secretory granule membrane]
(R-HSA-6801313)
ATAD3B [plasma membrane]
(R-HSA-6806518)
ATAD3B [ficolin-1-rich granule membrane]
(R-HSA-6801277)
0.462
4
UniProt:P06576 ATP5F1B
6
ATP5F1B [mitochondrial matrix]
(R-HSA-164576)
ATP5B(1-529) [cytosol]
(R-HSA-1267973)
ATP5B(1-529) [mitochondrial intermembrane space]
(R-HSA-1267985)
ATP5B(1-47) [mitochondrial matrix]
(R-HSA-8986172)
ATP5B(1-529) [mitochondrial inner membrane]
(R-HSA-1299440)
ATP5B [mitochondrial inner membrane]
(R-HSA-1299441)
0.462
2
UniProt:P40939 HADHA
1
HADHA [mitochondrial inner membrane]
(R-HSA-77264)
0.462
4
UniProt:Q86T03 TMEM55B
2
TMEM55B [nucleoplasm]
(R-HSA-6810405)
TMEM55B [late endosome membrane]
(R-HSA-6810395)
0.462
4
UniProt:Q9UBB4 ATX10
0.462
4
UniProt:P20020 ATP2B1
1
ATP2B1 [plasma membrane]
(R-HSA-418301)
0.462
2
UniProt:P78527 PRKDC
4
PRKDC [nucleoplasm]
(R-HSA-62161)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [cytosol]
(R-HSA-3134816)
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
0.462
2
UniProt:Q8TC07 TBC1D15
1
TBC1D15 [cytosol]
(R-HSA-8854150)
0.462
2
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.462
4
UniProt:P42695 NCAPD3
3
p-T1415,S1419-NCAPD3 [nucleoplasm]
(R-HSA-2294594)
p-T1415-NCAPD3 [nucleoplasm]
(R-HSA-2294587)
NCAPD3 [nucleoplasm]
(R-HSA-1629790)
0.462
2
UniProt:Q99653 CHP1
1
p-CHP1 [plasma membrane]
(R-HSA-5333747)
0.462
2
UniProt:Q9GZT3 SLIRP
1
SLIRP [mitochondrial matrix]
(R-HSA-9837039)
0.462
4
UniProt:Q15185 PTGES3
2
PTGES3 [nucleoplasm]
(R-HSA-5082403)
PTGES3 [cytosol]
(R-HSA-265269)
0.462
2
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