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EGLN1 [cytosol]
Stable Identifier
R-HSA-1234108
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Egl nine homolog 1, EGLN1_HUMAN, PHD2
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN1 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN1 [cytosol] (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN1 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN1 [cytosol] (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN1 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN1 [cytosol] (Homo sapiens)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN1 [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN1 [cytosol] (Homo sapiens)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN1 [cytosol] (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN1 [cytosol] (Homo sapiens)
Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)
VBC complex (with or without LIMD1) [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN1 [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9GZT9 EGLN1
Gene Names
EGLN1, C1orf12, PNAS-118, PNAS-137
Chain
initiator methionine:, chain:2-426
Reference Genes
BioGPS Gene:54583 EGLN1
COSMIC (genes):EGLN1 EGLN1
CTD Gene:54583 EGLN1
dbSNP Gene:54583 EGLN1
ENSEMBL:ENSG00000135766 EGLN1
HGNC:1232 EGLN1
KEGG:hsa:54583 EGLN1
Monarch:54583 EGLN1
NCBI Gene:54583 EGLN1
OMIM:606425 EGLN1
UCSC:Q9GZT9 EGLN1
Reference Transcript
RefSeq:NM_022051.2 EGLN1
Other Identifiers
11733856_s_at
11733857_x_at
11753665_x_at
1561893_PM_at
1561893_at
16700489
221497_PM_x_at
221497_x_at
223045_3p_at
223045_PM_at
223045_at
223046_PM_at
223046_at
224314_3p_s_at
224314_PM_s_at
224314_s_at
2460550
2460552
2460553
2460554
2460555
2460557
2460558
2460559
2460560
2460561
2460562
2460563
2460564
2460577
2460578
2460579
2460580
2460581
2460582
2460583
2460584
2460585
3605787
3605791
3605794
3605796
3605798
46228_at
54583
59784_at
61030_at
72412_at
77159_at
7925048
A_23_P343935
A_23_P34710
A_24_P410363
GE82642
GE86610
GO:0001666
GO:0003824
GO:0005506
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006355
GO:0006879
GO:0008198
GO:0014069
GO:0016491
GO:0016705
GO:0016706
GO:0019899
GO:0031418
GO:0031543
GO:0031545
GO:0032364
GO:0043226
GO:0043231
GO:0043433
GO:0045765
GO:0045944
GO:0046872
GO:0048856
GO:0051213
GO:0051344
GO:0055008
GO:0060347
GO:0060412
GO:0060711
GO:0071456
GO:0071731
GO:0098978
GO:0099159
GO:0140096
GO:0140252
GO:0160082
HMNXSV003011780
HMNXSV003013772
Hs.6523.1.A1_3p_at
Hs.6523.1.A1_3p_x_at
Hs.6523.1.A4_3p_at
Hs2.221730.1.A1_3p_at
ILMN_1749892
PH_hs_0027826
TC01003968.hg
TC01006192.hg
g12751078_3p_a_at
g12751078_3p_s_at
g13529208_3p_a_at
Participates
as a component of
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Inferred To
EGLN1 [cytosol]
(Bos taurus)
EGLN1 [cytosol]
(Caenorhabditis elegans)
EGLN1 [cytosol]
(Canis familiaris)
EGLN1 [cytosol]
(Gallus gallus)
EGLN1 [cytosol]
(Mus musculus)
EGLN1 [cytosol]
(Rattus norvegicus)
EGLN1 [cytosol]
(Sus scrofa)
egln1 [cytosol]
(Xenopus tropicalis)
Hph [cytosol]
(Drosophila melanogaster)
Cross References
ZINC - World Drugs
EGLN1_HUMAN
Guide to Pharmacology - Targets
2833
OpenTargets
ENSG00000135766
ENSEMBL
ENST00000366641
,
ENSP00000355601
ZINC - Substances
EGLN1_HUMAN
ZINC - Biogenic
EGLN1_HUMAN
ZINC target
Q9GZT9
PRO
Q9GZT9
GlyGen
Q9GZT9
PDB
6YW4
,
5LBB
,
6QGV
,
2HBU
,
4KBZ
,
5LBE
,
4BQW
,
5L9V
,
6YW2
,
7Q5V
,
5LAT
,
5L9B
,
6ZBO
,
6YW1
,
6ZBN
,
5V18
,
8J1K
,
2G1M
,
7UJV
,
6ST3
,
5OX5
,
3OUH
,
6YVW
,
3OUI
,
6YVT
,
2G19
,
2Y33
,
2HBT
,
4UWD
,
4BQY
,
7Q5X
,
5A3U
,
2Y34
,
5LBF
,
6YW3
,
4BQX
,
5LBC
,
5LB6
,
3HQR
,
7UMP
,
6YW0
,
5LAS
,
5L9R
,
3HQU
,
4JZR
,
6NMQ
,
6YVZ
,
5LA9
,
6YVX
,
5OX6
,
3OUJ
ZINC - Investigational
EGLN1_HUMAN
ZINC - Metabolites
EGLN1_HUMAN
HPA
ENSG00000135766-EGLN1
Pharos - Targets
Q9GZT9
Orphanet
EGLN1
ZINC - Predictions - Purchasable
EGLN1_HUMAN
HMDB Protein
HMDBP09210
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16665 HIF1A
7
HIF1A [nucleoplasm]
(R-HSA-1234135)
HIF1A [cytosol]
(R-HSA-1234102)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
HN-HIF1A [cytosol]
(R-HSA-1234110)
0.803
5
UniProt:Q99814 EPAS1 (HIF2A)
5
EPAS1 [cytosol]
(R-HSA-1234119)
EPAS1 [nucleoplasm]
(R-HSA-452560)
2xHP-EPAS1 [cytosol]
(R-HSA-1234149)
2xHP-EPAS1 [nucleoplasm]
(R-HSA-1234151)
HN-EPAS1 [cytosol]
(R-HSA-1234112)
0.635
3
UniProt:Q15185 PTGES3
2
PTGES3 [nucleoplasm]
(R-HSA-5082403)
PTGES3 [cytosol]
(R-HSA-265269)
0.527
3
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