Reactome | Cytosolic tRNA aminoacylation

Cytosolic tRNA aminoacylation

Stable Identifier

R-HSA-379716

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cytosolic tRNA synthetases catalyze the reactions of tRNAs encoded in the nuclear genome, their cognate amino acids, and ATP to form aminoacyl-tRNAs, AMP, and pyrophosphate. Eight of the tRNA synthetases, those specific for arginine, aspartate, glutamate and proline, glutamine, isoleucine, leucine, lysine, and methionine, associate to form a complex with three accessory proteins. Each of the component synthetases is active in vitro as a purified protein; complex formation is thought to channel aminoacylated tRNAs more efficiently to the site of protein synthesis in mRNA:ribosome complexes (Quevillon et al. 1999; Wolfe et al. 2003, 2005).

Literature References

PubMed ID	Title	Journal	Year
9878398	Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein Mirande, M, Quevillon, S, Siatecka, M, Berthonneau, E, Robinson, JC	J Mol Biol	1999
16169847	A three-dimensional working model of the multienzyme complex of aminoacyl-tRNA synthetases based on electron microscopic placements of tRNA and proteins Norcum, MT, Wolfe, CL, Treadwell, L, Warrington, JA	J Biol Chem	2005
14500886	Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII Norcum, MT, Green, S, Wolfe, CL, Davis, S, Warrington, JA	Protein Sci	2003