Reactome | Cytosolic tRNA aminoacylation

Cytosolic tRNA aminoacylation

Stable Identifier

R-HSA-379716

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

Cytosolic tRNA synthetases catalyze the reactions of tRNAs encoded in the nuclear genome, their cognate amino acids, and ATP to form aminoacyl-tRNAs, AMP, and pyrophosphate. Eight of the tRNA synthetases, those specific for arginine, aspartate, glutamate and proline, glutamine, isoleucine, leucine, lysine, and methionine, associate to form a complex with three accessory proteins. Each of the component synthetases is active in vitro as a purified protein; complex formation is thought to channel aminoacylated tRNAs more efficiently to the site of protein synthesis in mRNA:ribosome complexes (Quevillon et al. 1999; Wolfe et al. 2003, 2005).

Literature References

PubMed ID	Title	Journal	Year
9878398	Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein Quevillon, S, Robinson, JC, Berthonneau, E, Siatecka, M, Mirande, M	J Mol Biol	1999
16169847	A three-dimensional working model of the multienzyme complex of aminoacyl-tRNA synthetases based on electron microscopic placements of tRNA and proteins Wolfe, CL, Warrington, JA, Treadwell, L, Norcum, MT	J Biol Chem	2005
14500886	Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII Wolfe, CL, Warrington, JA, Davis, S, Green, S, Norcum, MT	Protein Sci	2003