Reactome | DCC interaction with SIAH1

DCC interaction with SIAH1

Stable Identifier

R-HSA-374665

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Siah-1 binds DCC and promotes its proteolysis via the ubiquitin-proteasome pathway. Siah-1 contains an N-terminal RING domain that is involved in proteolysis function and a C-terminal sequence that is involved in its oligomerization and binding to target proteins, such as DCC.

Literature References

PubMed ID	Title	Journal	Year
9858595	Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins Hu, G, Fearon, ER	Mol Cell Biol	1999