Reactome | PVRL2 [plasma membrane]

PVRL2 [plasma membrane]

Stable Identifier

R-HSA-419006

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Nectin-2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q92692 NECTIN2

Gene Names

NECTIN2, HVEB, PRR2, PVRL2

Chain

signal peptide:1-31, chain:32-538

Reference Genes

BioGPS Gene:5819 NECTIN2

COSMIC (genes):NECTIN2 NECTIN2

CTD Gene:5819 NECTIN2

dbSNP Gene:5819 NECTIN2

ENSEMBL:ENSG00000130202 NECTIN2

ENSEMBL_homo_sapiens_GENE:ENSG00000130202.10 NECTIN2

HGNC:9707 NECTIN2

KEGG Gene (Homo sapiens):5819 NECTIN2

Monarch:5819 NECTIN2

NCBI Gene:5819 NECTIN2

OMIM:600798 NECTIN2

UCSC:Q92692 NECTIN2

Reference Transcript

Other Identifiers

11718065_a_at

11719528_at

16863091

203149_PM_at

203149_at

225418_PM_at

225418_at

232078_PM_at

232078_at

232079_PM_s_at

232079_s_at

2688498

2688502

2688503

32156_at

3835815

3835816

3835817

3835823

3835824

3835825

3835827

3835830

3835831

3835836

3835837

3835838

3835839

3835840

3835843

3835845

3835846

3835847

3835848

50318_at

50320_g_at

5819

63982_at

64021_r_at

8029507

A_23_P208293

A_23_P352870

GE63090

GO:0001618

GO:0001675

GO:0002376

GO:0002860

GO:0002891

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0005911

GO:0005915

GO:0005925

GO:0007005

GO:0007010

GO:0007155

GO:0007156

GO:0007286

GO:0007289

GO:0009566

GO:0009986

GO:0015026

GO:0016020

GO:0019064

GO:0022414

GO:0023052

GO:0030154

GO:0030382

GO:0032989

GO:0033005

GO:0042271

GO:0042802

GO:0042803

GO:0043226

GO:0043296

GO:0044291

GO:0044406

GO:0044782

GO:0045954

GO:0046596

GO:0046718

GO:0046814

GO:0048856

GO:0050839

GO:0050862

GO:0051649

GO:0051654

GO:0060089

GO:0060370

GO:0061024

GO:0070062

GO:0098542

HMNXSV003004539

Hs.324036.0.S1_3p_s_at

Hs.8372.2.S1_3p_at

ILMN_1718303

ILMN_2255382

ILMN_2337336

PH_hs_0010845

TC19000631.hg

TC19002164.hg

g5360209_3p_at

Participates

as a component of

as an input of

as a member of

Nectin [plasma membrane] (Homo sapiens)

Inferred To

Nectin2 [plasma membrane] (Mus musculus)

Nectin2 [plasma membrane] (Rattus norvegicus)

NECTIN2 [plasma membrane] (Bos taurus)

NECTIN2 [plasma membrane] (Canis familiaris)

NECTIN2 [plasma membrane] (Sus scrofa)

nectin2 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001036189.1, NP_002847.1

OpenTargets

ENSG00000130202

HPA

ENSG00000130202-NECTIN2

GeneCards

Q92692

Ensembl

ENSP00000252483, ENSG00000130202, ENST00000252483, ENST00000252485, ENSP00000252485

PRO

Q92692

Pharos - Targets

Q92692

PDB

4HZA, 3R0N, 4DFH, 5V52, 4DFI

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92692 NECTIN2	1	PVRL2 [plasma membrane] (R-HSA-419006)	0.89	8
UniProt:Q495A1 TIGIT			0.786	6
UniProt:Q9NQS3 NECTIN3	1	PVRL3 [plasma membrane] (R-HSA-449762)	0.702	4
UniProt:Q99750 MDFI			0.666	4
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q7Z3S9 NT2NA			0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:P60370 KRTAP10-5	1	KRTAP10-5 [cytosol] (R-HSA-6810260)	0.556	3
IntAct:EBI-10173330 386677			0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.556	3
UniProt:P55196 AFDN			0.499	2
UniProt:Q9H3Z4 DNAJC5	5	DNAJC5 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-9659623) DNAJC5 [specific granule membrane] (R-HSA-6800990) DNAJC5 [azurophil granule membrane] (R-HSA-6799144) DNAJC5 [plasma membrane] (R-HSA-936512) DNAJC5 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888598)	0.471	2

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