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KCNJ10 [plasma membrane]
Stable Identifier
R-HSA-975290
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ATP-sensitive inward rectifier potassium channel 10, IRK10_HUMAN, kir 4.1
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Potassium Channels (Homo sapiens)
Inwardly rectifying K+ channels (Homo sapiens)
G protein gated Potassium channels (Homo sapiens)
Activation of G protein gated Potassium channels (Homo sapiens)
Activation of GIRK/Kir3 Channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
Potassium transport channels (Homo sapiens)
Activation of Potassium transport channels (Homo sapiens)
Potassium transport channels (Kir 1.1 and Kir 4.1/5.1) [plasma membrane] (Homo sapiens)
Kir 4.1/5.1 heterotetramer [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
GABA receptor activation (Homo sapiens)
GABA B receptor activation (Homo sapiens)
Activation of GABAB receptors (Homo sapiens)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Homo sapiens)
Activation of GIRK/Kir3 Channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
Kir heterotetramers [plasma membrane] (Homo sapiens)
Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
KCNJ10 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78508 KCNJ10
Gene Names
KCNJ10
Chain
chain:1-379
Reference Genes
BioGPS Gene:3766 KCNJ10
COSMIC (genes):KCNJ10 KCNJ10
CTD Gene:3766 KCNJ10
dbSNP Gene:3766 KCNJ10
ENSEMBL:ENSG00000177807 KCNJ10
HGNC:6256 KCNJ10
KEGG Gene (Homo sapiens):3766 KCNJ10
Monarch:3766 KCNJ10
NCBI Gene:3766 KCNJ10
OMIM:602208 KCNJ10
UCSC:P78508 KCNJ10
Reference Transcript
RefSeq:NM_002241.4 KCNJ10
Other Identifiers
0000520132
11723211_at
11723212_at
11758609_s_at
16695262
206692_PM_at
206692_at
228581_PM_at
228581_at
2439959
2439961
2439962
2439963
2439964
2439965
2439968
33951_at
3766
46478_at
46631_at
47699_at
7921533
82525_at
A_23_P114736
A_24_P387875
GE59226
GO:0000166
GO:0003674
GO:0005242
GO:0005244
GO:0005267
GO:0005515
GO:0005524
GO:0005575
GO:0005886
GO:0005887
GO:0005929
GO:0006810
GO:0006811
GO:0006813
GO:0007267
GO:0007601
GO:0007628
GO:0008150
GO:0014003
GO:0015272
GO:0016020
GO:0016021
GO:0016323
GO:0022010
GO:0022607
GO:0022857
GO:0030154
GO:0034765
GO:0042391
GO:0042592
GO:0043167
GO:0043226
GO:0044297
GO:0048169
GO:0048856
GO:0050877
GO:0051935
GO:0055075
GO:0055085
GO:0060075
GO:0071805
GO:0097449
GO:0097546
GO:0098793
GO:1905515
GO:1990573
HMNXSV003007727
Hs.6899.0.A1_3p_at
Hs.6899.0.A1_3p_x_at
ILMN_1808272
PH_hs_0004060
TC01003396.hg
U52155_at
g4504832_3p_at
Participates
as a component of
Kir 4.1/5.1 heterotetramer [plasma membrane] (Homo sapiens)
Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
as a member of
Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
Inferred To
Kcnj10 [plasma membrane]
(Mus musculus)
Kcnj10 [plasma membrane]
(Rattus norvegicus)
irk-2 [plasma membrane]
(Caenorhabditis elegans)
kcnj10a [plasma membrane]
(Danio rerio)
kcnj10 [plasma membrane]
(Xenopus tropicalis)
Irk1 [plasma membrane]
(Drosophila melanogaster)
irk-3 [plasma membrane]
(Caenorhabditis elegans)
Homologues of KCNJ10 [plasma membrane]
(Caenorhabditis elegans)
Homologues of KCNJ10 [plasma membrane]
(Drosophila melanogaster)
KCNJ10 [plasma membrane]
(Bos taurus)
KCNJ10 [plasma membrane]
(Canis familiaris)
KCNJ10 [plasma membrane]
(Sus scrofa)
Irk3 [plasma membrane]
(Drosophila melanogaster)
irk-1 [plasma membrane]
(Caenorhabditis elegans)
Irk2 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_002232.2
Guide to Pharmacology - Targets
438
OpenTargets
ENSG00000177807
ZINC - Substances
KCJ10_HUMAN
ZINC target
P78508
ZINC - Biogenic
KCJ10_HUMAN
PRO
P78508
ZINC - Investigational
KCJ10_HUMAN
ZINC - Metabolites
KCJ10_HUMAN
GeneCards
P78508
HPA
ENSG00000177807-KCNJ10
Ensembl
ENSP00000491250
,
ENSG00000177807
,
ENSP00000492619
,
ENST00000644903
,
ENST00000638868
,
ENSP00000495557
,
ENST00000638728
Pharos - Targets
P78508
Orphanet
18371
HMDB Protein
HMDBP08735
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IUQ4 SIAH1
1
SIAH1 [cytosol]
(R-HSA-374563)
0.556
3
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