Reactome | KCNJ10 [plasma membrane]

KCNJ10 [plasma membrane]

Stable Identifier

R-HSA-975290

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ATP-sensitive inward rectifier potassium channel 10, IRK10_HUMAN, kir 4.1

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Inwardly rectifying K+ channels (Homo sapiens)
    - G protein gated Potassium channels (Homo sapiens)
      - Activation of G protein gated Potassium channels (Homo sapiens)
        
        Activation of GIRK/Kir3 Channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)
        
        Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)
        
        Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)
        
        Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)
        
        Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)
    - Potassium transport channels (Homo sapiens)
      - Activation of Potassium transport channels (Homo sapiens)
        
        Potassium transport channels (Kir 1.1 and Kir 4.1/5.1) [plasma membrane] (Homo sapiens)
        
        Kir 4.1/5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)
- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Homo sapiens)
        
        Activation of GIRK/Kir3 Channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)
        
        Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)
        
        Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)
        
        Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)
        
        Kir4.1:Kir5.1 heterotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ10 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P78508 KCNJ10

Gene Names

KCNJ10

Chain

chain:1-379

Reference Genes

BioGPS Gene:3766 KCNJ10

COSMIC (genes):KCNJ10 KCNJ10

CTD Gene:3766 KCNJ10

dbSNP Gene:3766 KCNJ10

ENSEMBL:ENSG00000177807 KCNJ10

HGNC:6256 KCNJ10

KEGG Gene (Homo sapiens):3766 KCNJ10

Monarch:3766 KCNJ10

NCBI Gene:3766 KCNJ10

OMIM:602208 KCNJ10

UCSC:P78508 KCNJ10

Reference Transcript

RefSeq:NM_002241.4 KCNJ10

Other Identifiers

0000520132

11723211_at

11723212_at

11758609_s_at

16695262

206692_at

228581_at

2439959

2439961

2439962

2439963

2439964

2439965

2439968

33951_at

3766

46478_at

46631_at

47699_at

7921533

82525_at

A_23_P114736

A_24_P387875

GE59226

GO:0000166

GO:0003674

GO:0005242

GO:0005244

GO:0005267

GO:0005515

GO:0005524

GO:0005575

GO:0005886

GO:0005887

GO:0006810

GO:0006811

GO:0006813

GO:0007267

GO:0007601

GO:0007628

GO:0008150

GO:0014003

GO:0015272

GO:0016020

GO:0016021

GO:0016323

GO:0022010

GO:0022857

GO:0030154

GO:0034765

GO:0042391

GO:0042592

GO:0043167

GO:0044297

GO:0048169

GO:0048856

GO:0050877

GO:0051935

GO:0055075

GO:0055085

GO:0060075

GO:0071805

GO:0097449

GO:0098793

GO:1990573

Hs.6899.0.A1_3p_at

Hs.6899.0.A1_3p_x_at

ILMN_1808272

PH_hs_0004060

TC01003396.hg

U52155_at

g4504832_3p_at

Participant Of

hasComponent

hasMember

Kirx.x that interacts with Kir2.1 [plasma membrane]

Inferred To

Kcnj10 [plasma membrane] (Mus musculus)

Kcnj10 [plasma membrane] (Rattus norvegicus)

irk-2 [plasma membrane] (Caenorhabditis elegans)

kcnj10a [plasma membrane] (Danio rerio)

kcnj10 [plasma membrane] (Xenopus tropicalis)

irk-3 [plasma membrane] (Caenorhabditis elegans)

Homologues of KCNJ10 [plasma membrane] (Caenorhabditis elegans)

KCNJ10 [plasma membrane] (Bos taurus)

KCNJ10 [plasma membrane] (Sus scrofa)

Irk3 [plasma membrane] (Drosophila melanogaster)

irk-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002232.2

OpenTargets

ENSG00000177807

HPA

ENSG00000177807-KCNJ10

GeneCards

P78508

ZINC target

P78508

Ensembl

ENST00000638868, ENST00000638728, ENSP00000491250, ENSG00000177807, ENSP00000492619, ENST00000644903, ENSP00000495557

PRO

P78508

Orphanet

18371

HMDB Protein

HMDBP08735

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.556	3

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