Reactome | AFF4 [nucleoplasm]

AFF4 [nucleoplasm]

Stable Identifier

R-HSA-8932788

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

AF4/FMR2 family member 4, AFF4_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UHB7 AFF4

Gene Names

AFF4, AF5Q31, MCEF, HSPC092

Chain

chain:1-1163

Reference Genes

BioGPS Gene:27125 AFF4

COSMIC (genes):AFF4 AFF4

CTD Gene:27125 AFF4

dbSNP Gene:27125 AFF4

ENSEMBL:ENSG00000072364 AFF4

HGNC:17869 AFF4

KEGG Gene (Homo sapiens):27125 AFF4

Monarch:27125 AFF4

NCBI Gene:27125 AFF4

OMIM:604417 AFF4

UCSC:Q9UHB7 AFF4

Reference Transcript

Other Identifiers

0004610519

11720420_at

11720421_at

11720422_s_at

11720423_at

11745285_x_at

11748674_x_at

1555436_a_at

16999897

219199_at

225229_at

232864_s_at

232865_at

239439_at

243487_at

244628_at

27125

2875546

2875548

2875550

2875552

2875554

2875556

2875557

2875558

2875559

2875560

2875562

2875563

2875564

2875566

2875567

2875568

2875570

2875571

2875573

2875574

2875577

2875580

2875581

2875583

2875584

2875585

2875586

2875589

2875592

2875601

2875603

2875604

2875605

2875606

2875614

2875615

2875616

43728_at

46059_at

52929_at

55886_at

80329_at

8114083

87410_at

A_23_P218977

A_24_P286079

A_24_P394408

A_24_P8318

A_24_P942636

GE61681

GE61997

GO:0000003

GO:0001650

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006366

GO:0006368

GO:0007286

GO:0008023

GO:0008150

GO:0009058

GO:0010468

GO:0030154

GO:0032783

GO:0032991

GO:0034641

GO:0035327

GO:0043226

GO:0048856

HMNXSV003020957

Hs.11637.0.A1_3p_at

Hs.231967.1.A1_3p_a_at

Hs.269664.0.A1_3p_at

Hs.269664.0.A1_3p_x_at

Hs.282908.0.A1_3p_at

Hs.88808.0.A1_3p_at

ILMN_1708502

PH_hs_0026122

TC05001776.hg

TC05003238.hg

g7656878_3p_at

Participates

as an output of

Elongating transcript encounters a lesion in the template (Homo sapiens)

as a component of

as an input of

Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)

Inferred To

AFF4 [nucleoplasm] (Bos taurus)

AFF4 [nucleoplasm] (Canis familiaris)

AFF4 [nucleoplasm] (Gallus gallus)

AFF4 [nucleoplasm] (Sus scrofa)

lilli [nucleoplasm] (Drosophila melanogaster)

kcnab2 [nucleoplasm] (Xenopus tropicalis)

Aff4 [nucleoplasm] (Mus musculus)

Aff4 [nucleoplasm] (Rattus norvegicus)

aff4 [nucleoplasm] (Danio rerio)

Ghost homologue of AFF4 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of AFF4 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of AFF4 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of AFF4 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_055238.1, XP_005272020.1

OpenTargets

ENSG00000072364

GeneCards

Q9UHB7

HPA

ENSG00000072364-AFF4

Ensembl

ENST00000265343, ENST00000378595, ENSG00000072364, ENSP00000265343, ENSP00000367858

PRO

Q9UHB7

Pharos - Targets

Q9UHB7

Orphanet

23593

GlyGen

Q9UHB7

PDB

6KN5, 6K7P, 4OR5, 4IMY, 6CYT, 5JW9, 6R80, 4OGR, 5L1Z

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.831	9
UniProt:O60563 CCNT1	1	CCNT1 [nucleoplasm] (R-HSA-51611)	0.758	6
UniProt:Q03111 MLLT1	1	MLLT1 [nucleoplasm] (R-HSA-8932918)	0.691	8
UniProt:O00472 ELL2	1	ELL2 [nucleoplasm] (R-HSA-6807506)	0.643	4
UniProt:P51825 AFF1			0.597	8
UniProt:P42568 MLLT3	1	MLLT3 [nucleoplasm] (R-HSA-8932789)	0.564	4
UniProt:P04608 tat	1	Tat (P04608) [nucleoplasm] (R-HIV-175856)	0.558	4
UniProt:P63010 AP2B1	4	AP2B1 [endolysosome membrane] (R-HSA-6784827) AP2B1 [plasma membrane] (R-HSA-167690) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [cytosol] (R-HSA-182166)	0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.556	5
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	4
UniProt:Q96CJ1 EAF2	1	EAF2 [nucleoplasm] (R-HSA-8932790)	0.527	2
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.527	3
UniProt:P55199 ELL	1	ELL [nucleoplasm] (R-HSA-54257)	0.527	2

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