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AFF4 [nucleoplasm]
Stable Identifier
R-HSA-8932788
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
AF4/FMR2 family member 4, AFF4_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Abortive termination of elongation after arrest (Homo sapiens)
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Elongating transcript encounters a lesion in the template (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Resumption of elongation after recovery from pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription Elongation (Homo sapiens)
Addition of nucleotides leads to transcript elongation (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Formation of RNA Pol II elongation complex (Homo sapiens)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Recruitment of elongation factors to form elongation complex (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Pol II elongation complex moves on the template as transcript elongates (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Separation of elongating transcript from template (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UHB7 AFF4
Gene Names
AFF4, AF5Q31, MCEF, HSPC092
Chain
chain:1-1163
Reference Genes
BioGPS Gene:27125 AFF4
COSMIC (genes):AFF4 AFF4
CTD Gene:27125 AFF4
dbSNP Gene:27125 AFF4
ENSEMBL:ENSG00000072364 AFF4
ENSEMBL_homo_sapiens_GENE:ENSG00000072364.13 AFF4
HGNC:17869 AFF4
KEGG Gene (Homo sapiens):27125 AFF4
Monarch:27125 AFF4
NCBI Gene:27125 AFF4
OMIM:604417 AFF4
UCSC:Q9UHB7 AFF4
Reference Transcript
RefSeq:XM_005271963.4 AFF4
RefSeq:NM_014423.3 AFF4
Other Identifiers
11720420_at
11720421_at
11720422_s_at
11720423_at
11745285_x_at
11748674_x_at
1555436_PM_a_at
1555436_a_at
16999897
219199_PM_at
219199_at
225229_PM_at
225229_at
232864_PM_s_at
232864_s_at
232865_PM_at
232865_at
239439_PM_at
239439_at
243487_PM_at
243487_at
244628_PM_at
244628_at
27125
2875546
2875548
2875550
2875552
2875554
2875556
2875557
2875558
2875559
2875560
2875562
2875563
2875564
2875566
2875567
2875568
2875570
2875571
2875573
2875574
2875577
2875580
2875581
2875583
2875584
2875585
2875586
2875589
2875592
2875601
2875603
2875604
2875605
2875606
2875614
2875615
2875616
43728_at
46059_at
52929_at
55886_at
80329_at
8114083
87410_at
A_23_P218977
A_24_P286079
A_24_P394408
A_24_P8318
A_24_P942636
GE61681
GE61997
GO:0000791
GO:0001650
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0007286
GO:0008023
GO:0010468
GO:0022414
GO:0030154
GO:0032783
GO:0034976
GO:0043226
GO:0048856
HMNXSV003020957
Hs.11637.0.A1_3p_at
Hs.231967.1.A1_3p_a_at
Hs.269664.0.A1_3p_at
Hs.269664.0.A1_3p_x_at
Hs.282908.0.A1_3p_at
Hs.88808.0.A1_3p_at
ILMN_1708502
PH_hs_0026122
TC05001776.hg
TC05003238.hg
g7656878_3p_at
Participates
as an output of
Elongating transcript encounters a lesion in the template (Homo sapiens)
as a component of
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
as an input of
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
Inferred To
AFF4 [nucleoplasm]
(Bos taurus)
AFF4 [nucleoplasm]
(Canis familiaris)
AFF4 [nucleoplasm]
(Gallus gallus)
AFF4 [nucleoplasm]
(Sus scrofa)
lilli [nucleoplasm]
(Drosophila melanogaster)
Aff4 [nucleoplasm]
(Mus musculus)
Aff4 [nucleoplasm]
(Rattus norvegicus)
aff4 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of AFF4 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of AFF4 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of AFF4 [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of AFF4 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_055238.1
,
XP_005272020.1
OpenTargets
ENSG00000072364
GeneCards
Q9UHB7
HPA
ENSG00000072364-AFF4
Ensembl
ENSP00000367858
,
ENSG00000072364
,
ENSP00000265343
,
ENST00000265343
,
ENST00000378595
PRO
Q9UHB7
Pharos - Targets
Q9UHB7
Orphanet
23593
PDB
6K7P
,
6KN5
,
5L1Z
,
4IMY
,
4OR5
,
6R80
,
6CYT
,
5JW9
,
4OGR
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P50750 CDK9
1
CDK9 [nucleoplasm]
(R-HSA-51801)
0.87
12
UniProt:O60563 CCNT1
1
CCNT1 [nucleoplasm]
(R-HSA-51611)
0.81
8
UniProt:Q03111 MLLT1
1
MLLT1 [nucleoplasm]
(R-HSA-8932918)
0.758
11
UniProt:O00472 ELL2
1
ELL2 [nucleoplasm]
(R-HSA-6807506)
0.725
6
UniProt:P55199 ELL
1
ELL [nucleoplasm]
(R-HSA-54257)
0.643
4
UniProt:Q96JC9 EAF1
1
EAF1 [nucleoplasm]
(R-HSA-8932787)
0.643
6
UniProt:Q96CJ1 EAF2
1
EAF2 [nucleoplasm]
(R-HSA-8932790)
0.643
3
UniProt:P51825 AFF1
0.597
8
UniProt:P42568 MLLT3
1
MLLT3 [nucleoplasm]
(R-HSA-8932789)
0.564
4
UniProt:P04608 tat
1
Tat (P04608) [nucleoplasm]
(R-HIV-175856)
0.558
4
UniProt:P63010 AP2B1
4
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [cytosol]
(R-HSA-182166)
AP2B1 [plasma membrane]
(R-HSA-167690)
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q5JR59 MTUS2
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:Q8IUQ4 SIAH1
1
SIAH1 [cytosol]
(R-HSA-374563)
0.556
5
UniProt:O94992 HEXI1
0.527
2
UniProt:O95402 MED26
1
MED26 [nucleoplasm]
(R-HSA-556783)
0.527
4
UniProt:Q9HB65 ELL3
1
ELL3 [nucleoplasm]
(R-HSA-6807497)
0.527
3
UniProt:Q9H6A0 DENND2D
1
DENND2D [cytosol]
(R-HSA-8876071)
0.527
2
UniProt:P40425 PBX2
0.527
2
UniProt:Q5VWQ0 RSBN1
0.527
2
UniProt:O00541 PES1
1
PES1 [nucleoplasm]
(R-HSA-6791207)
0.527
2
UniProt:Q8IZU1 FAM9A
0.527
2
UniProt:P48426 PIP4K2A
2
PIP4K2A [nucleoplasm]
(R-HSA-6811484)
PIP4K2A [cytosol]
(R-HSA-1604641)
0.527
2
UniProt:P21741 MDK
1
MDK [extracellular region]
(R-HSA-2160953)
0.527
2
UniProt:O60583 CCNT2
1
CCNT2 [nucleoplasm]
(R-HSA-51613)
0.527
3
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