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AFF4 [nucleoplasm]
Stable Identifier
R-HSA-8932788
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
AF4/FMR2 family member 4, AFF4_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Abortive termination of elongation after arrest (Homo sapiens)
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Elongating transcript encounters a lesion in the template (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Resumption of elongation after recovery from pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription Elongation (Homo sapiens)
Addition of nucleotides leads to transcript elongation (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Formation of RNA Pol II elongation complex (Homo sapiens)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Recruitment of elongation factors to form elongation complex (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Pol II elongation complex moves on the template as transcript elongates (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Separation of elongating transcript from template (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
AFF4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UHB7 AFF4
Gene Names
AFF4, AF5Q31, MCEF, HSPC092
Chain
chain:1-1163
Reference Genes
BioGPS Gene:27125 AFF4
COSMIC (genes):AFF4 AFF4
CTD Gene:27125 AFF4
dbSNP Gene:27125 AFF4
ENSEMBL:ENSG00000072364 AFF4
ENSEMBL_homo_sapiens_GENE:ENSG00000072364 AFF4
HGNC:17869 AFF4
KEGG Gene (Homo sapiens):27125 AFF4
Monarch:27125 AFF4
NCBI Gene:27125 AFF4
OMIM:604417 AFF4
UCSC:Q9UHB7 AFF4
Reference Transcript
RefSeq:NM_014423.3 AFF4
RefSeq:XM_005271963.4 AFF4
Other Identifiers
0004610519
11720420_at
11720421_at
11720422_s_at
11720423_at
11745285_x_at
11748674_x_at
1555436_a_at
16999897
219199_at
225229_at
232864_s_at
232865_at
23690
239439_at
243487_at
27125
2875557
2875558
2875559
2875560
2875562
2875563
2875564
2875566
2875567
2875568
2875570
2875571
2875573
2875574
2875577
2875580
2875581
2875583
2875584
2875585
2875586
2875589
2875592
2875601
2875603
2875604
2875605
2875606
2875614
2875615
2875616
29634
46059_at
4IMY
4OGR
4OR5
52929_at
55886_at
5JW9
5L1Z
80329_at
8114083
87410_at
A_23_P218977
A_24_P286079
A_24_P394408
A_24_P8318
A_24_P942636
AAF18981
AAF28915
AAH63007
AAI00288
AAI37227
AAM00184
AFF4
AFF4-201
AFF4-203
BAD92784
CCDS4164
EAW62305
ENSG00000072364
ENSP00000265343
ENSP00000367858
ENST00000265343
ENST00000378595
EntrezGene:27125
g7656878_3p_at
GE61681
GE61997
GO:0000003
GO:0001650
GO:0003674
GO:0003677
GO:0003690
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0006355
GO:0006366
GO:0006368
GO:0007286
GO:0008023
GO:0008150
GO:0009058
GO:0030154
GO:0032783
GO:0032991
GO:0034641
GO:0035327
GO:0043226
GO:0048856
HGNC:17869
HPA023690
HPA029634
Hs.11637.0.A1_3p_at
Hs.231967.1.A1_3p_a_at
Hs.282908.0.A1_3p_at
Hs.88808.0.A1_3p_at
ILMN_1708502
IPR007797
MIM:604417
MIM:616368
NM_014423
NP_055238
PF05110
PH_hs_0026122
TC05001776.hg
TC05003238.hg
uc003kyd.4
uc003kye.2
UPI000006F558
UPI000066DA10
XM_005271963
XM_005271964
XM_006714587
XP_005272020
XP_005272021
XP_006714650
Participant Of
input
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
output
Elongating transcript encounters a lesion in the template
hasComponent
Aborted elongation complex after arrest [nucleoplasm]
Arrested processive elongation complex [nucleoplasm]
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm]
Elongation complex prior to separation [nucleoplasm]
Elongation complex with separated and uncleaved transcript [nucleoplasm]
Paused processive elongation complex [nucleoplasm]
Processive elongation complex [nucleoplasm]
Inferred To
AFF4 [nucleoplasm] (Bos taurus)
AFF4 [nucleoplasm] (Canis familiaris)
AFF4 [nucleoplasm] (Danio rerio)
AFF4 [nucleoplasm] (Drosophila melanogaster)
AFF4 [nucleoplasm] (Gallus gallus)
AFF4 [nucleoplasm] (Mus musculus)
AFF4 [nucleoplasm] (Rattus norvegicus)
AFF4 [nucleoplasm] (Sus scrofa)
AFF4 [nucleoplasm] (Taeniopygia guttata)
AFF4 [nucleoplasm] (Xenopus tropicalis)
Homologues of AFF4 [nucleoplasm] (Canis familiaris)
Homologues of AFF4 [nucleoplasm] (Danio rerio)
Homologues of AFF4 [nucleoplasm] (Sus scrofa)
Ghost homologue of AFF4 [nucleoplasm] (Caenorhabditis elegans)
Ghost homologue of AFF4 [nucleoplasm] (Dictyostelium discoideum)
Cross References
RefSeq
NP_055238.1
,
XP_005272020.1
OpenTargets
ENSG00000072364
GeneCards
Q9UHB7
DOCK Blaster
4IMY
,
4OR5
,
4OGR
,
5L1Z
,
5JW9
PRO
Q9UHB7
Orphanet
23593
PDB
4IMY
,
4OGR
,
4OR5
,
5L1Z
,
5JW9
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P50750 CDK9
1
CDK9 [nucleoplasm]
(R-HSA-51801)
0.783
8
UniProt:Q03111 MLLT1
1
MLLT1 [nucleoplasm]
(R-HSA-8932918)
0.691
8
UniProt:O60563 CCNT1
1
CCNT1 [nucleoplasm]
(R-HSA-51611)
0.691
5
UniProt:P51825 AFF1
0.597
8
UniProt:P42568 MLLT3
1
MLLT3 [nucleoplasm]
(R-HSA-8932789)
0.564
4
UniProt:P04608 tat
1
Tat (P04608) [nucleoplasm]
(R-HIV-175856)
0.558
4
UniProt:P63010 AP2B1
4
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [cytosol]
(R-HSA-182166)
AP2B1 [plasma membrane]
(R-HSA-167690)
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
0.556
3
UniProt:Q5JR59 MTUS2
0.556
3
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:Q08379 GOLGA2
3
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q8IUQ4 SIAH1
1
SIAH1 [cytosol]
(R-HSA-374563)
0.556
5
UniProt:O00472 ELL2
1
ELL2 [nucleoplasm]
(R-HSA-6807506)
0.527
3
UniProt:O95402 MED26
1
MED26 [nucleoplasm]
(R-HSA-556783)
0.527
4
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