SNCA is monoubiquitinated and under some circumstances released to accumulate in the cell. Alternatively Ub-SNCA may undergo further rounds of ubiquitination producing diubiquitinated or polyubiquitinated forms. The precise mechanism of release and subsequent further ubiquitination is unclear (Sadowski et al. 2011); the E3 ligase may remain bound to SNCA while the E2 ligase dissociates to be replaced by a Ubiquitin-associated replacement, or the E2/E3 complex may dissociate completely allowing a different E3 to bind the SNCA substrate.
Sadowski, M, Tan, AR, Suryadinata, R, Roesley, SN, Sarcevic, B
Liani, E, Avraham, E, Rott, R, Engelender, S, Shainskaya, A, Haskin, J, Szargel, R, Manov, I, Shani, V
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