Reactome | CXCR4 [plasma membrane]

CXCR4 [plasma membrane]

Stable Identifier

R-HSA-2980772

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

C-X-C chemokine receptor type 4, CXCR4_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q8TD22 SFXN5

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External Reference Information

External Reference

UniProt:P61073 CXCR4

Gene Names

CXCR4

Chain

chain:1-352

Reference Genes

BioGPS Gene:7852 CXCR4

COSMIC - genes:CXCR4 CXCR4

CTD Gene:7852 CXCR4

dbSNP Gene:7852 CXCR4

ENSEMBL:ENSG00000121966 CXCR4

HGNC:2561 CXCR4

KEGG:hsa:7852 CXCR4

Monarch:7852 CXCR4

NCBI Gene:7852 CXCR4

OMIM:162643 CXCR4

UCSC:P61073 CXCR4

Reference Transcript

Other Identifiers

11728189_a_at

11728190_s_at

11728191_x_at

11739094_a_at

16903140

209201_3p_x_at

209201_PM_x_at

209201_x_at

211919_PM_s_at

211919_s_at

217028_PM_at

217028_at

2578041

2578042

2578043

2578044

2578045

2578046

2578047

2578048

2578049

2578050

2578051

2578052

2578053

649_s_at

7852

8055465

A_23_P102000

GE54062

GO:0001618

GO:0001666

GO:0002376

GO:0002407

GO:0003779

GO:0004930

GO:0004950

GO:0005515

GO:0005737

GO:0005764

GO:0005768

GO:0005769

GO:0005770

GO:0005886

GO:0006915

GO:0006935

GO:0006954

GO:0006955

GO:0007165

GO:0007186

GO:0007189

GO:0007193

GO:0007204

GO:0007420

GO:0008092

GO:0009615

GO:0009897

GO:0009986

GO:0015026

GO:0016020

GO:0016477

GO:0016493

GO:0016494

GO:0019722

GO:0019955

GO:0019957

GO:0022008

GO:0030154

GO:0030155

GO:0030334

GO:0030335

GO:0031252

GO:0031410

GO:0031625

GO:0032027

GO:0032991

GO:0038147

GO:0038160

GO:0043130

GO:0043217

GO:0046718

GO:0048714

GO:0048856

GO:0048870

GO:0060326

GO:0061024

GO:0070062

GO:0070098

GO:0070161

GO:0071345

GO:0120162

GO:1904018

GO:2000448

HMNXSV003031179

Hs.89414.1.S1_3p_at

ILMN_1801584

ILMN_1898567

ILMN_2246410

ILMN_2320888

L06797_s_at

PH_hs_0019757

TC02002378.hg

g13549089_3p_s_at

g189313_3p_a_at

Participates

as an output of

as a member of

as a protein marker of

definitive endoderm cell (Homo sapiens)

as a component of

CXCR4:CXCL12 [plasma membrane] (Homo sapiens)

Inferred To

npr-32 [plasma membrane] (Caenorhabditis elegans)

cxcr4a [plasma membrane] (Danio rerio)

cxcr4 [plasma membrane] (Xenopus tropicalis)

CXCR4 [plasma membrane] (Bos taurus)

CXCR4 [plasma membrane] (Gallus gallus)

CXCR4 [plasma membrane] (Sus scrofa)

Cxcr4 [plasma membrane] (Mus musculus)

Cxcr4 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001334989.1, NP_001334988.1, NP_001334985.1, NP_003458.1, NP_001008540.1

ZINC - World Drugs

CXCR4_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000121966

ENSEMBL

ENSG00000121966, ENST00000241393, ENSP00000386884, ENSP00000241393, ENST00000409817

ZINC - FDA approved

CXCR4_HUMAN

ZINC - Substances

CXCR4_HUMAN

ZINC target

P61073

PRO

P61073

GlyGen

P61073

PDB

9MEN, 8ZPM, 8ZPL, 3OE6, 3ODU, 3OE9, 2N55, 9MDU, 8U4T, 8K3Z, 3OE0, 9MEJ, 2K05, 2K03, 2K04, 3OE8, 8GP3, 8U4Q, 8I0Q, 8U4O, 8U4N, 8U4P, 8U4R, 4RWS, 8U4S, 9ME1, 9MET, 8YU7, 8ZPN, 9MEU

ZINC - Investigational

CXCR4_HUMAN

GeneCards

CXCR4

HPA

ENSG00000121966-CXCR4

Pharos - Targets

P61073

Orphanet

CXCR4

ZINC - Predictions - Purchasable

CXCR4_HUMAN

HMDB Protein

HMDBP07643

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25106 ACKR3	1	CXCR7 [plasma membrane] (R-HSA-373859)	0.853	18
UniProt:Q16643 DBN1	1	DBN1 [cytosol] (R-HSA-9714666)	0.702	5
UniProt:P51681 CCR5	1	CCR5 [plasma membrane] (R-HSA-171279)	0.675	4
UniProt:Q5T3F8 TM63B			0.643	3
UniProt:P35348 ADRA1A	1	ADRA1A [plasma membrane] (R-HSA-390669)	0.606	10
UniProt:P35368 ADRA1B	1	ADRA1B [plasma membrane] (R-HSA-390661)	0.606	9
UniProt:O60603 TLR2	3	TLR2 [plasma membrane] (R-HSA-167992) TLR2 [secretory granule membrane] (R-HSA-6804777) TLR2 [plasma membrane] (R-HSA-9637646)	0.59	3
UniProt:P04233 CD74	13	CD74 [plasma membrane] (R-HSA-2130666) CD74 [lysosomal membrane] (R-HSA-2130320) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(81-104) [lysosomal lumen] (R-HSA-2213220)	0.556	4
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.556	5
UniProt:Q07266-1 DBN1			0.556	3
UniProt:Q96J02-2 ITCH			0.537	3
UniProt:Q9BTX1 NDC1	1	NDC1 [nuclear envelope] (R-HSA-6805183)	0.527	2
UniProt:Q99720 SIGMAR1	1	SIGMAR1 [cytosol] (R-HSA-9679757)	0.527	2
UniProt:O15554 KCNN4	1	KCNN4 [plasma membrane] (R-HSA-977543)	0.527	2
UniProt:O15360 FANCA	2	FANCA [cytosol] (R-HSA-420796) FANCA [nucleoplasm] (R-HSA-419541)	0.527	3
UniProt:Q8TD22 SFXN5			0.527	2
UniProt:Q6IBW4 NCAPH2	2	p-S-NCAPH2 [nucleoplasm] (R-HSA-2294589) NCAPH2 [nucleoplasm] (R-HSA-1629797)	0.527	2
UniProt:Q86U38 NOP9			0.527	3
UniProt:O75907 DGAT1	3	DGAT1 [plasma membrane] (R-HSA-6806313) DGAT1 [specific granule membrane] (R-HSA-6799564) DGAT1 [endoplasmic reticulum membrane] (R-HSA-53579)	0.527	2
UniProt:Q8N5B7 CERS5	1	CERS5 [endoplasmic reticulum membrane] (R-HSA-428168)	0.527	2
UniProt:O43909 EXTL3	2	EXTL3 [Golgi membrane] (R-HSA-9941179) EXTL3 [endoplasmic reticulum membrane] (R-HSA-535476)	0.527	2
UniProt:Q8WV83 S35F5			0.527	2
UniProt:O60427 FADS1	1	FADS1 [endoplasmic reticulum membrane] (R-HSA-400122)	0.527	2
UniProt:Q9BXJ8 TACAN			0.527	2
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.527	2
UniProt:Q92508 PIEZO1	1	PIEZO1 [plasma membrane] (R-HSA-9855044)	0.527	2
UniProt:Q9Y5W7 SNX14			0.527	2
UniProt:Q9Y5W8 SNX13			0.527	2
UniProt:Q6P1A2 LPCAT3	1	LPCAT3 [endoplasmic reticulum membrane] (R-HSA-428994)	0.527	2
UniProt:Q9GZM5 YIPF3			0.527	3
UniProt:P42695 NCAPD3	3	p-T1415,S1419-NCAPD3 [nucleoplasm] (R-HSA-2294594) p-T1415-NCAPD3 [nucleoplasm] (R-HSA-2294587) NCAPD3 [nucleoplasm] (R-HSA-1629790)	0.527	2
UniProt:Q96CB8 INTS12	1	INTS12 [nucleoplasm] (R-HSA-6807456)	0.527	2
UniProt:Q96ED9 HOOK2			0.527	2
UniProt:O14939 PLD2	2	PLD2 [plasma membrane] (R-HSA-2029075) PLD2 [endoplasmic reticulum membrane] (R-HSA-1498791)	0.527	2
UniProt:A0PK00 T120B			0.527	2
UniProt:P49682 CXCR3	1	CXCR3 [plasma membrane] (R-HSA-2980699)	0.512	5
UniProt:Q04900 MUC24			0.499	2

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