Reactome | CCR5 [plasma membrane]

CCR5 [plasma membrane]

Stable Identifier

R-HSA-171279

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

C-C chemokine receptor type 5

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Early Phase of HIV Life Cycle (Homo sapiens)
        
        Binding and entry of HIV virion (Homo sapiens)
        
        CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4 (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
        
        CD4:Env gp120:CCR5,CXCR4:complex [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Conformational changes in gp120 exposes gp41 (Homo sapiens)
        
        Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
        
        CD4:Env gp120:CCR5,CXCR4:complex [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Virion with gp41 exposed [extracellular region] (Homo sapiens)
        
        CCR5/CXCR4:CD4:Env gp120 (second conformation change) complex [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Fusion of viral membrane with host cell membrane (Homo sapiens)
        
        CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Fusogenic activation of gp41 (Homo sapiens)
        
        Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41 fusion peptide complex:CCR5 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Virion with gp41 exposed [extracellular region] (Homo sapiens)
        
        CCR5/CXCR4:CD4:Env gp120 (second conformation change) complex [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Insertion of gp41 fusion peptide into the target membrane (Homo sapiens)
        
        Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41 fusion peptide complex:CCR5 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41insertion complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        N and C terminal heptad repeat helices of gp41 form six-helix bundle (Homo sapiens)
        
        Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41insertion complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptors CCR3, 4 and 5 bind CCL5 ligand (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P51681 CCR5

Gene Names

CCR5, CMKBR5

Chain

chain:1-352

Reference Genes

BioGPS Gene:1234 CCR5

COSMIC (genes):CCR5 CCR5

CTD Gene:1234 CCR5

dbSNP Gene:1234 CCR5

ENSEMBL:ENSG00000160791 CCR5

HGNC:1606 CCR5

KEGG:hsa:1234 CCR5

Monarch:1234 CCR5

NCBI Gene:1234 CCR5

OMIM:601373 CCR5

UCSC:P51681 CCR5

Reference Transcript

Other Identifiers

11730909_s_at

11730910_s_at

11748062_s_at

1234

16940182

206991_PM_s_at

206991_s_at

2620858

2620859

2620861

36724_s_at

4047176

4047177

4047179

8079401

8093298

A_23_P412321

GE80926

GO:0000165

GO:0001618

GO:0002376

GO:0002407

GO:0003779

GO:0003824

GO:0004435

GO:0004930

GO:0004950

GO:0005515

GO:0005737

GO:0005768

GO:0005886

GO:0006816

GO:0006935

GO:0006952

GO:0006954

GO:0006955

GO:0006968

GO:0007166

GO:0007186

GO:0007204

GO:0007267

GO:0008092

GO:0009897

GO:0009986

GO:0014808

GO:0015026

GO:0016020

GO:0016493

GO:0016787

GO:0019722

GO:0019957

GO:0023052

GO:0031410

GO:0042802

GO:0043226

GO:0046718

GO:0048870

GO:0055085

GO:0060089

GO:0060326

GO:0070098

GO:0070723

GO:0071222

GO:0071791

GO:2000110

HMNXSV003029170

ILMN_1653395

ILMN_2145033

PH_hs_0031237

TC03002321.hg

U83326_s_at

U95626_rna3_at

X99393_s_at

g4502638_3p_a_at

Participates

as a member of

Inferred To

Ccr5 [plasma membrane] (Mus musculus)

Ccr5 [plasma membrane] (Rattus norvegicus)

CCR5 [plasma membrane] (Bos taurus)

CCR5 [plasma membrane] (Canis familiaris)

CCR5 [plasma membrane] (Gallus gallus)

CCR5 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_000570.1, NP_001093638.1

ZINC - World Drugs

CCR5_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000160791

ENSEMBL

ENSP00000292303, ENST00000292303, ENST00000445772, ENSP00000404881

ZINC - FDA approved

CCR5_HUMAN

ZINC - Substances

CCR5_HUMAN

ZINC - Biogenic

CCR5_HUMAN

ZINC target

P51681

PRO

P51681

GlyGen

P51681

PDB

2RRS, 2RLL, 2L87, 5YY4, 2MZX, 6MET, 7O7F, 5YD5, 5YD4, 7NJZ, 6FGP, 5UIW, 7F1Q, 8AS2, 6MEO, 5YD3, 7F1S, 8AS3, 4MBS, 7NW3, 7F1R

ZINC - Investigational

CCR5_HUMAN

ZINC - Metabolites

CCR5_HUMAN

HPA

ENSG00000160791-CCR5

Pharos - Targets

P51681

ZINC - Predictions - Purchasable

CCR5_HUMAN

HMDB Protein

HMDBP07578

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61073 CXCR4	1	CXCR4 [plasma membrane] (R-HSA-2980772)	0.675	4
UniProt:P01730 CD4	4	CD4 [plasma membrane] (R-HSA-167542) CD4 [endoplasmic reticulum membrane] (R-HSA-180575) CD4 [early endosome] (R-HSA-182147) CD4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869082)	0.667	3
UniProt:P13501 CCL5	1	CCL5(24-91) [extracellular region] (R-HSA-373108)	0.656	6

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