Reactome | Ac-K3016-ATM [nucleoplasm]

Ac-K3016-ATM [nucleoplasm]

Stable Identifier

R-HSA-5682043

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13315 ATM

Gene Names

ATM

Chain

initiator methionine:, chain:2-3056

Reference Genes

BioGPS Gene:472 ATM

COSMIC (genes):ATM ATM

CTD Gene:472 ATM

dbSNP Gene:472 ATM

ENSEMBL:ENSG00000149311 ATM

ENSEMBL_homo_sapiens_GENE:ENSG00000149311.21 ATM

HGNC:795 ATM

KEGG Gene (Homo sapiens):472 ATM

Monarch:472 ATM

NCBI Gene:472 ATM

OMIM:607585 ATM

UCSC:Q13315 ATM

Reference Transcript

Other Identifiers

11720013_a_at

11720014_a_at

11741374_x_at

11745546_a_at

11751874_a_at

16730845

1862_at

1863_s_at

2000_at

2001_g_at

208442_PM_s_at

208442_s_at

210858_PM_x_at

210858_x_at

212672_PM_at

212672_at

3002284

3347659

3347660

3347662

3347665

3347666

3347667

3347668

3347675

3347678

3347679

3347680

3347681

3347682

3347683

3347684

3347685

3347686

3347687

3347688

3347689

3347690

3347691

3347693

3347694

3347695

3347696

3347697

3347698

3347699

3347700

3347701

3347702

3347703

3347704

3347707

3347708

3347709

3347710

3347712

3347713

3347714

3347715

3347716

3347719

3347721

3347722

3347723

3347724

3347725

3347727

3347729

3347730

3347731

3347734

3347736

3347738

3347739

3347740

3347741

3347742

3347743

3347744

3347745

3347747

3347748

3347750

3347751

3347752

3347754

3347757

3347758

3347759

3347763

3347764

3347766

3347769

3347770

3347772

3347773

3347774

3347775

3347776

3347777

3347778

472

7943620

91853_at

A_14_P117132

A_14_P119595

A_14_P131864

A_14_P134778

A_23_P35916

A_23_P374812

A_33_P3589722

GE80884

GE87169

GO:0000077

GO:0000166

GO:0000278

GO:0000425

GO:0000723

GO:0000724

GO:0000781

GO:0001541

GO:0001666

GO:0001756

GO:0002331

GO:0002376

GO:0003677

GO:0003824

GO:0004672

GO:0004674

GO:0004677

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005777

GO:0005782

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0006281

GO:0006302

GO:0006303

GO:0006310

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006468

GO:0006629

GO:0006914

GO:0006954

GO:0006974

GO:0006977

GO:0007049

GO:0007059

GO:0007094

GO:0007095

GO:0007131

GO:0007140

GO:0007143

GO:0007155

GO:0007165

GO:0007292

GO:0007420

GO:0007507

GO:0008340

GO:0008585

GO:0008630

GO:0009791

GO:0010212

GO:0010506

GO:0010628

GO:0012501

GO:0016071

GO:0016301

GO:0016303

GO:0016310

GO:0016740

GO:0018105

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0030335

GO:0030889

GO:0031410

GO:0032200

GO:0032210

GO:0032212

GO:0033151

GO:0034614

GO:0035264

GO:0035979

GO:0036092

GO:0036211

GO:0036289

GO:0042159

GO:0042770

GO:0042802

GO:0042981

GO:0043065

GO:0043226

GO:0043231

GO:0043517

GO:0043525

GO:0044877

GO:0045141

GO:0045785

GO:0045944

GO:0046777

GO:0048538

GO:0048584

GO:0048599

GO:0048856

GO:0048870

GO:0051171

GO:0051402

GO:0051726

GO:0060255

GO:0065003

GO:0070192

GO:0071044

GO:0071300

GO:0071479

GO:0071480

GO:0071481

GO:0071500

GO:0080090

GO:0080135

GO:0090398

GO:0090399

GO:0097694

GO:0097695

GO:0106310

GO:0140013

GO:0140014

GO:0140096

GO:1900034

GO:1901796

GO:1903626

GO:1903978

GO:1904262

GO:1904354

GO:1904358

GO:1904884

GO:1990391

HMNXSV003008456

HMNXSV003025399

Hs.194382.2.S1_3p_at

ILMN_1713630

ILMN_1779214

ILMN_2370825

PH_hs_0026560

TC11000980.hg

TC11002857.hg

U33841_at

U67092_s_at

X91196_s_at

g4502266_3p_a_at

Participates

as a component of

Ac-K3016-ATM dimer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

ATM [nucleoplasm]

p-S1981,Ac-K3016-ATM [nucleoplasm]

ATM [peroxisomal matrix]

ATM [cytosol]

Inferred To

TEL1 [nucleoplasm] (Saccharomyces cerevisiae)

tel1 [nucleoplasm] (Schizosaccharomyces pombe)

Atm [nucleoplasm] (Mus musculus)

Atm [nucleoplasm] (Rattus norvegicus)

tefu [nucleoplasm] (Drosophila melanogaster)

Ac-K3016-ATM [nucleoplasm] (Gallus gallus)

atr1 [nucleoplasm] (Dictyostelium discoideum)

ATM [nucleoplasm] (Bos taurus)

ATM [nucleoplasm] (Canis familiaris)

ATM [nucleoplasm] (Sus scrofa)

Modified Residues

Name

N6-acetyl-L-lysine at 3016

Coordinate

3016

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

XP_006718906.1, XP_016873279.1, XP_006718908.1, XP_005271619.2, XP_005271618.2, XP_011541142.1, XP_016873278.1, NP_000042.3

Guide to Pharmacology - Targets

1934

OpenTargets

ENSG00000149311

ZINC - Substances

ATM_HUMAN

ZINC target

Q13315

ZINC - Biogenic

ATM_HUMAN

PRO

Q13315

PDB

5NP0, 6HKA, 7NI6, 7SID, 8OXQ, 8OXM, 7NI5, 7SIC, 7NI4, 5NP1, 6K9L, 6K9K, 8OXO, 8OXP

ZINC - Metabolites

ATM_HUMAN

IntEnz

2.7.11.1

GeneCards

Q13315

HPA

ENSG00000149311-ATM

Ensembl

ENST00000675843, ENST00000452508, ENSP00000501606, ENST00000278616, ENSP00000388058, ENSP00000278616, ENSG00000149311

Pharos - Targets

Q13315

ZINC - Predictions - Purchasable

ATM_HUMAN

Orphanet

15962

HMDB Protein

HMDBP01231

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00519 ABL1	6	p-Y393-ABL1 [cytosol] (R-HSA-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.704	4
UniProt:Q9Y4R8 TELO2			0.677	4
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.659	8
UniProt:P54274-2 TERF1			0.65	5
UniProt:O43156 TTI1			0.612	5
UniProt:P54274 TERF1	1	TERF1 [nucleoplasm] (R-HSA-164618)	0.609	3
UniProt:Q14676 MDC1	6	monoSUMO1-K1840-MDC1 [nucleoplasm] (R-HSA-4570546) polySUMO2,3-K1840-MDC1 [nucleoplasm] (R-HSA-4570473) K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684074) SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684061) p-5T-MDC1 [nucleoplasm] (R-HSA-75236) MDC1 [nucleoplasm] (R-HSA-75231)	0.604	3
UniProt:Q9BQ15 NABP2	1	NABP2 [nucleoplasm] (R-HSA-6814916)	0.602	4
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) TP53BP1 [nucleoplasm] (R-HSA-61175)	0.571	2
UniProt:O43313 ATMIN			0.556	5
UniProt:P27958-PRO_0000037577			0.556	3
UniProt:P62508-3 ESRRG			0.556	3
UniProt:Q15554 TERF2	2	TERF2 [nucleoplasm] (R-HSA-174895) p-S365-TERF2 [nucleoplasm] (R-HSA-9686530)	0.544	2
UniProt:Q5XUX0 FBXO31	1	FBXO31 [cytosol] (R-HSA-8850911)	0.544	2
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.544	3
UniProt:Q9NZQ7 CD274	1	CD274 [plasma membrane] (R-HSA-3211776)	0.527	2
UniProt:P32970 CD70	1	CD70 [plasma membrane] (R-HSA-5667139)	0.527	2
UniProt:P49146 NPY2R	1	NPY2R [plasma membrane] (R-HSA-388905)	0.527	2
UniProt:Q86VZ1 P2RY8			0.527	2
UniProt:Q99677 LPAR4	1	LPAR4 [plasma membrane] (R-HSA-418020)	0.527	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.524	4
UniProt:P11245 NAT2	2	AcC-NAT2 [cytosol] (R-HSA-158833) NAT2 [cytosol] (R-HSA-158692)	0.508	2
UniProt:Q9BZ95 NSD3	1	WHSC1L1 [nucleoplasm] (R-HSA-1183230)	0.508	3
UniProt:Q13007 IL24	1	IL24 [extracellular region] (R-HSA-448438)	0.508	2
UniProt:Q7LG56 RRM2B	1	RRM2B [cytosol] (R-HSA-111792)	0.499	3
UniProt:O60934 NBN	3	p-S343-NBN [nucleoplasm] (R-HSA-75237) NBN [cytosol] (R-HSA-5684005) NBN [nucleoplasm] (R-HSA-75163)	0.499	2
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.491	2
IntAct:EBI-9086707 NS3			0.463	2
IntAct:EBI-6863782 NS3			0.463	6
UniProt:Q6PJG6 BRAT1			0.463	3

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