Reactome | CXCR4 [plasma membrane]

CXCR4 [plasma membrane]

Stable Identifier

R-BTA-2980772

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

CXCR4, P25930

Locations in the PathwayBrowser

Expand all

Signal Transduction (Bos taurus)

- Signaling by GPCR (Bos taurus)
  - GPCR downstream signalling (Bos taurus)
    - G alpha (i) signalling events (Bos taurus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Bos taurus)
        
        CXCR4,7 [plasma membrane] (Bos taurus)
        
        CXCR4 [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Bos taurus)
        
        CXCR4,7 [plasma membrane] (Bos taurus)
        
        CXCR4 [plasma membrane] (Bos taurus)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Bos taurus)
        
        CXCR4,7 [plasma membrane] (Bos taurus)
        
        CXCR4 [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Bos taurus)
        
        CXCR4,7 [plasma membrane] (Bos taurus)
        
        CXCR4 [plasma membrane] (Bos taurus)
      - The Ligand:GPCR:Gi complex dissociates (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Bos taurus)
        
        CXCR4,7 [plasma membrane] (Bos taurus)
        
        CXCR4 [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Bos taurus)
        
        CXCR4,7 [plasma membrane] (Bos taurus)
        
        CXCR4 [plasma membrane] (Bos taurus)
  - GPCR ligand binding (Bos taurus)
    - Class A/1 (Rhodopsin-like receptors) (Bos taurus)
      - Peptide ligand-binding receptors (Bos taurus)
        
        Chemokine receptors bind chemokines (Bos taurus)
        
        Receptors CXCR4 and 7 bind CXCL12 ligand (Bos taurus)
        
        CXCR4,7 [plasma membrane] (Bos taurus)
        
        CXCR4 [plasma membrane] (Bos taurus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Bos taurus)
        
        CXCR4,7 [plasma membrane] (Bos taurus)
        
        CXCR4 [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:P25930

Gene Names

CXCR4

Reference Genes

BioGPS Gene:281736 CXCR4

ENSEMBL:ENSBTAG00000001060

KEGG Gene (Bos taurus):281736 CXCR4

Monarch:281736 CXCR4

NCBI Gene:281736 CXCR4

Reference Transcript

RefSeq:NM_174301.3 CXCR4

Other Identifiers

GO:0001666

GO:0002376

GO:0003779

GO:0004930

GO:0004950

GO:0005764

GO:0005768

GO:0005769

GO:0005770

GO:0005773

GO:0005886

GO:0006935

GO:0006955

GO:0007155

GO:0007165

GO:0007186

GO:0007204

GO:0007420

GO:0008092

GO:0009897

GO:0009986

GO:0016020

GO:0016493

GO:0019722

GO:0019955

GO:0019957

GO:0022008

GO:0023052

GO:0030154

GO:0030155

GO:0030335

GO:0031252

GO:0031410

GO:0031625

GO:0032027

GO:0032991

GO:0038147

GO:0038160

GO:0043130

GO:0043226

GO:0048856

GO:0048870

GO:0050920

GO:0060089

GO:0060326

GO:0070098

GO:0070161

GO:0071345

GO:1904018

GO:2000448

Participates

as a component of

CXCR4:CXCL12 [plasma membrane] (Bos taurus)

as a member of

CXCR4,7 [plasma membrane] (Bos taurus)

Inferred From

CXCR4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_776726.1

OpenTargets

ENSG00000121966

Ensembl

ENSBTAP00000001406, ENSBTAG00000001060, ENSBTAT00000001406

VGNC

27856

HMDB Protein

HMDBP13788