Expression of CXCR4 in primordial germ cells

Stable Identifier
R-HSA-9828028
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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Expression of CXCR4 in primordial germ cells
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Human PGCs express CXCR4 on their cell membranes (Mishra et al. 2021, Tang et al. 2022). In human PGCs differentiated in vitro, SOX17 directly activates expression of CXCR4 (Tang et al. 2022). In mouse embryos (Ara et al. 2003, Molyneaux et al. 2003) and zebrafish embryos (Doitsidou et al. 2002), Cxcr4 on PGCs interacts with its ligand, Cxcl12 which is secreted by somatopleur mesenchyme and genital ridges, and guides the migration of PGCs.
Literature References
PubMed ID Title Journal Year
33470497 Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells

Tilleman, L, Menten, B, van Nieuwerburgh, F, Popovic, M, Chuva De Sousa Lopes, SM, Taelman, J, Mishra, S, Van Der Jeught, M, Boel, A, De Sutter, P, Deforce, D, Duthoo, E, Heindryckx, B

Stem Cells 2021
35411086 Sequential enhancer state remodelling defines human germline competence and specification

Castillo-Venzor, A, Tang, WWC, Surani, MA, Sun, D, Gruhn, WH, Penfold, CA, Kobayashi, T, Irie, N, Morgan, MD

Nat Cell Biol 2022
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
SOX17:CXCR4 gene [nucleoplasm] (Homo sapiens)
Active Unit
SOX17 [nucleoplasm]
Authored
May, B  (2023-02-09)
Reviewed
Tam, PPL  (2023-05-03)
Created
May, B  (2023-02-09)
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