Reactome | CXCR7 [plasma membrane]

CXCR7 [plasma membrane]

Stable Identifier

R-HSA-373859

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

C-X-C chemokine receptor type 7, CXCR7_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
        
        CXCR4,7 [plasma membrane] (Homo sapiens)
        
        CXCR7 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
        
        CXCR4,7 [plasma membrane] (Homo sapiens)
        
        CXCR7 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
        
        CXCR4,7 [plasma membrane] (Homo sapiens)
        
        CXCR7 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
        
        CXCR4,7 [plasma membrane] (Homo sapiens)
        
        CXCR7 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
        
        CXCR4,7 [plasma membrane] (Homo sapiens)
        
        CXCR7 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
        
        CXCR4,7 [plasma membrane] (Homo sapiens)
        
        CXCR7 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptors CXCR4 and 7 bind CXCL12 ligand (Homo sapiens)
        
        CXCR4,7 [plasma membrane] (Homo sapiens)
        
        CXCR7 [plasma membrane] (Homo sapiens)
        
        CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
        
        CXCR4,7 [plasma membrane] (Homo sapiens)
        
        CXCR7 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25106 ACKR3

Gene Names

ACKR3, CMKOR1, CXCR7, GPR159, RDC1

Chain

chain:1-362

Reference Genes

BioGPS Gene:57007 ACKR3

COSMIC (genes):ACKR3 ACKR3

CTD Gene:57007 ACKR3

dbSNP Gene:57007 ACKR3

ENSEMBL:ENSG00000144476 ACKR3

ENSEMBL_homo_sapiens_GENE:ENSG00000144476.6 ACKR3

HGNC:23692 ACKR3

KEGG Gene (Homo sapiens):57007 ACKR3

Monarch:57007 ACKR3

NCBI Gene:57007 ACKR3

OMIM:610376 ACKR3

UCSC:P25106 ACKR3

Reference Transcript

Other Identifiers

11722597_a_at

11722598_s_at

11744541_a_at

11752501_a_at

16892826

212977_PM_at

212977_at

2534005

2534017

2534018

2534019

2534020

2534021

34288_at

57007

8049471

A_14_P120005

A_14_P200874

A_23_P131676

GE59352

GO:0001525

GO:0001570

GO:0002376

GO:0004930

GO:0005044

GO:0005515

GO:0005768

GO:0005769

GO:0005886

GO:0005905

GO:0006935

GO:0006955

GO:0007155

GO:0007165

GO:0007186

GO:0007204

GO:0008285

GO:0009897

GO:0009986

GO:0012501

GO:0015026

GO:0016020

GO:0016192

GO:0016493

GO:0016494

GO:0019722

GO:0019956

GO:0019957

GO:0019958

GO:0021557

GO:0023052

GO:0030154

GO:0031410

GO:0031623

GO:0038024

GO:0043226

GO:0043231

GO:0048856

GO:0048870

GO:0055037

GO:0060089

GO:0060326

GO:0070098

GO:0070374

GO:1902230

GO:1905322

HMNXSV003001831

Hs.23016.0.S1_3p_at

ILMN_1798360

ILMN_2371458

PH_hs_0023155

U67784_at

Participates

as a member of

CXCR4,7 [plasma membrane] (Homo sapiens)

Inferred To

npr-32 [plasma membrane] (Caenorhabditis elegans)

ackr3b [plasma membrane] (Danio rerio)

Ackr3 [plasma membrane] (Mus musculus)

Ackr3 [plasma membrane] (Rattus norvegicus)

ACKR3 [plasma membrane] (Bos taurus)

ACKR3 [plasma membrane] (Canis familiaris)

ACKR3 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_064707.1, XP_005246154.1, XP_005246155.1, XP_016860005.1

Guide to Pharmacology - Targets

OpenTargets

ENSG00000144476

GeneCards

P25106

HPA

ENSG00000144476-ACKR3

ZINC - Substances

ACKR3_HUMAN

Ensembl

ENST00000272928, ENSP00000272928, ENSG00000144476

ZINC target

P25106

PRO

P25106

Pharos - Targets

P25106

ZINC - Predictions - Purchasable

ACKR3_HUMAN

PDB

7SK3, 6K3F, 7SK7, 7SK5, 7SK4, 7SK9, 7SK8, 7SK6

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61073 CXCR4	1	CXCR4 [plasma membrane] (R-HSA-2980772)	0.853	18
UniProt:P06576 ATP5F1B	6	ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B [mitochondrial inner membrane] (R-HSA-1299441) ATP5F1B [mitochondrial matrix] (R-HSA-164576)	0.643	3
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.463	2