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PIEZO1 [plasma membrane]
Stable Identifier
R-HSA-9855044
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Piezo-type mechanosensitive ion channel component 1, PIEZ1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes (Homo sapiens)
PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients (Homo sapiens)
PIEZO1 trimer [plasma membrane] (Homo sapiens)
PIEZO1 [plasma membrane] (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients (Homo sapiens)
PIEZO1 trimer [plasma membrane] (Homo sapiens)
PIEZO1 [plasma membrane] (Homo sapiens)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients (Homo sapiens)
PIEZO1 trimer [plasma membrane] (Homo sapiens)
PIEZO1 [plasma membrane] (Homo sapiens)
PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) (Homo sapiens)
PIEZO1 trimer [plasma membrane] (Homo sapiens)
PIEZO1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92508 PIEZO1
Gene Names
PIEZO1, FAM38A, KIAA0233
Chain
chain:1-2521
Reference Genes
BioGPS Gene:9780 PIEZO1
COSMIC (genes):PIEZO1 PIEZO1
CTD Gene:9780 PIEZO1
dbSNP Gene:9780 PIEZO1
ENSEMBL:ENSG00000103335 PIEZO1
HGNC:28993 PIEZO1
KEGG:hsa:9780 PIEZO1
Monarch:9780 PIEZO1
NCBI Gene:9780 PIEZO1
OMIM:611184 PIEZO1
UCSC:Q92508 PIEZO1
Reference Transcript
RefSeq:NM_001142864.4 PIEZO1
Other Identifiers
11717662_a_at
16829170
202771_PM_at
202771_at
3704339
3704377
3704378
3704379
3704380
3704381
3704382
3704383
3704384
3704385
3704386
3704387
3704388
3704389
3704390
3704391
3704392
3704393
3704394
3704395
3704396
3704397
3704398
3704399
3704400
3704401
3704405
3704406
3704407
3704408
3704409
3704410
3704411
3704412
3704413
3704414
3704415
3704416
3704417
3704418
3704419
3704420
3704421
3704422
3704423
3704424
3704425
3704426
3704427
3704429
3704430
3704431
3704432
3704433
3704434
3704435
3704436
3704437
3704438
3704439
3704440
3704441
3704443
3704444
3704445
3704446
3704447
3704448
3704449
3704450
3704451
3704452
3704453
3704454
3704455
3704456
3704457
3704458
3704459
3704460
3704461
3704462
3704488
3704490
37281_at
8003357
9780
A_19_P00316629
A_19_P00802413
A_23_P140738
D87071_at
GO:0005215
GO:0005261
GO:0005515
GO:0005783
GO:0005789
GO:0005886
GO:0006812
GO:0008381
GO:0010831
GO:0016020
GO:0031258
GO:0032420
GO:0032437
GO:0033116
GO:0033625
GO:0033634
GO:0034220
GO:0042391
GO:0042995
GO:0043226
GO:0050982
GO:0055085
GO:0071260
GO:0098655
GO:0140135
HMNXSV003010287
HMNXSV003016191
HMNXSV003055503
ILMN_1752249
PH_hs_0031350
TC16001343.hg
TC16002024.hg
g7662013_3p_at
Participates
as a component of
PIEZO1 trimer [plasma membrane] (Homo sapiens)
Cross References
RefSeq
NP_001136336.2
Guide to Pharmacology - Targets
2945
ENSEMBL
ENSP00000301015
,
ENSG00000103335
,
ENST00000301015
OpenTargets
ENSG00000103335
GeneCards
PIEZO1
HPA
ENSG00000103335-PIEZO1
PRO
Q92508
Pharos - Targets
Q92508
GlyGen
Q92508
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04155 TFF1
1
TFF1 [extracellular region]
(R-HSA-9017879)
0.602
5
UniProt:P17931 LGALS3
3
LGALS3 [plasma membrane]
(R-HSA-879445)
LGALS3 [secretory granule membrane]
(R-HSA-6803327)
LGALS3 [ficolin-1-rich granule membrane]
(R-HSA-6803307)
0.527
2
UniProt:P61073 CXCR4
1
CXCR4 [plasma membrane]
(R-HSA-2980772)
0.527
2
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