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CXCR3 [plasma membrane]
Stable Identifier
R-HSA-2980699
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
C-X-C chemokine receptor type 3, CXCR3_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
CXCR3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
CXCR3 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
CXCR3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
CXCR3 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
CXCR3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
CXCR3 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptor CXCR3 binds ligands CXCL9 to 11 (Homo sapiens)
CXCR3 [plasma membrane] (Homo sapiens)
CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
CXCR3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49682 CXCR3
Gene Names
CXCR3, GPR9
Chain
chain:1-368
Reference Genes
BioGPS Gene:2833 CXCR3
COSMIC (genes):CXCR3 CXCR3
CTD Gene:2833 CXCR3
dbSNP Gene:2833 CXCR3
ENSEMBL:ENSG00000186810 CXCR3
HGNC:4540 CXCR3
KEGG:hsa:2833 CXCR3
Monarch:2833 CXCR3
NCBI Gene:2833 CXCR3
OMIM:300574 CXCR3
UCSC:P49682 CXCR3
Reference Transcript
RefSeq:XM_054326871.1 CXCR3
RefSeq:NM_001504.2 CXCR3
RefSeq:XM_017029435.2 CXCR3
RefSeq:NM_001142797.2 CXCR3
Participates
as an input of
Receptor CXCR3 binds ligands CXCL9 to 11 (Homo sapiens)
as a component of
CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
Inferred To
CXCR3 [plasma membrane]
(Bos taurus)
CXCR3 [plasma membrane]
(Canis familiaris)
CXCR3 [plasma membrane]
(Sus scrofa)
cxcr3.1 [plasma membrane]
(Danio rerio)
Cxcr3 [plasma membrane]
(Mus musculus)
Cxcr3 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001136269.1
,
NP_001495.1
,
XP_054182846.1
,
XP_016884924.1
Guide to Pharmacology - Targets
70
OpenTargets
ENSG00000186810
ENSEMBL
ENSP00000362797
,
ENSP00000362795
,
ENST00000373691
,
ENST00000373693
,
ENSG00000186810
ZINC - Substances
CXCR3_HUMAN
ZINC target
P49682
PRO
P49682
GlyGen
P49682
PDB
8K2W
,
8K2X
,
8Y0H
,
8XXY
,
8Y0N
,
8HNK
,
8HNM
,
8XYI
,
8XYK
,
8HNN
,
8HNL
,
8XXZ
HPA
ENSG00000186810-CXCR3
GeneCards
CXCR3
Pharos - Targets
P49682
ZINC - Predictions - Purchasable
CXCR3_HUMAN
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N6F1-2 CLDN19
0.556
3
UniProt:Q9Y6G1 TM14A
0.556
3
UniProt:O14523 C2C2L
0.556
3
UniProt:P61073 CXCR4
1
CXCR4 [plasma membrane]
(R-HSA-2980772)
0.512
5
UniProt:P49682 CXCR3
1
CXCR3 [plasma membrane]
(R-HSA-2980699)
0.463
3
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