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CXCR3 [plasma membrane]
Stable Identifier
R-HSA-2980699
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
C-X-C chemokine receptor type 3, CXCR3_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
CXCR3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
CXCR3 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
CXCR3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
CXCR3 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
CXCR3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
CXCR3 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptor CXCR3 binds ligands CXCL9 to 11 (Homo sapiens)
CXCR3 [plasma membrane] (Homo sapiens)
CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
CXCR3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49682 CXCR3
Gene Names
CXCR3, GPR9
Chain
chain:1-368
Reference Genes
BioGPS Gene:2833 CXCR3
COSMIC (genes):CXCR3 CXCR3
CTD Gene:2833 CXCR3
dbSNP Gene:2833 CXCR3
ENSEMBL:ENSG00000186810 CXCR3
HGNC:4540 CXCR3
KEGG:hsa:2833 CXCR3
Monarch:2833 CXCR3
NCBI Gene:2833 CXCR3
OMIM:300574 CXCR3
UCSC:P49682 CXCR3
Reference Transcript
RefSeq:XM_017029435.1 CXCR3
RefSeq:NM_001504.1 CXCR3
RefSeq:NM_001142797.1 CXCR3
Other Identifiers
11734606_a_at
17111955
207681_PM_at
207681_at
217119_PM_s_at
217119_s_at
2833
34077_at
4011990
4011991
4011992
4011993
4011994
4011995
4011996
4011997
4011998
4011999
8173493
A_23_P114299
A_33_P3389230
GE87847
GO:0001525
GO:0001937
GO:0002376
GO:0002685
GO:0004930
GO:0004950
GO:0005515
GO:0005737
GO:0005886
GO:0006355
GO:0006915
GO:0006935
GO:0006954
GO:0006955
GO:0007155
GO:0007166
GO:0007186
GO:0007189
GO:0007204
GO:0008284
GO:0009897
GO:0009986
GO:0012501
GO:0016020
GO:0016493
GO:0016494
GO:0016525
GO:0019722
GO:0019956
GO:0019957
GO:0019958
GO:0030155
GO:0038023
GO:0045766
GO:0045944
GO:0048870
GO:0050921
GO:0051281
GO:0060089
GO:0060326
GO:0070098
GO:1900118
GO:1900119
HMNXSV003005786
Hs.198252.1.S1_3p_a_at
ILMN_1797975
PH_hs_0027971
TC0X001128.hg
U32674_s_at
X95876_at
g4504098_3p_at
Participates
as an input of
Receptor CXCR3 binds ligands CXCL9 to 11 (Homo sapiens)
as a component of
CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
Inferred To
CXCR3 [plasma membrane]
(Bos taurus)
CXCR3 [plasma membrane]
(Canis familiaris)
CXCR3 [plasma membrane]
(Sus scrofa)
cxcr3.1 [plasma membrane]
(Danio rerio)
Cxcr3 [plasma membrane]
(Mus musculus)
Cxcr3 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001136269.1
,
NP_001495.1
,
XP_016884924.1
Guide to Pharmacology - Targets
70
ENSEMBL
ENST00000373691
,
ENSP00000362795
,
ENSP00000362797
,
ENST00000373693
OpenTargets
ENSG00000186810
HPA
ENSG00000186810-CXCR3
ZINC - Substances
CXCR3_HUMAN
ZINC target
P49682
PRO
P49682
Pharos - Targets
P49682
GlyGen
P49682
ZINC - Predictions - Purchasable
CXCR3_HUMAN
PDB
8HNN
,
8HNL
,
8HNM
,
8HNK
,
8K2W
,
8K2X
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14523 C2C2L
0.556
3
UniProt:Q9Y6G1 TM14A
0.556
3
UniProt:Q8N6F1-2 CLDN19
0.556
3
UniProt:P61073 CXCR4
1
CXCR4 [plasma membrane]
(R-HSA-2980772)
0.512
5
UniProt:P49682 CXCR3
1
CXCR3 [plasma membrane]
(R-HSA-2980699)
0.463
3
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