Reactome | CERS5 [endoplasmic reticulum membrane]

CERS5 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-428168

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

LASS5, LAG1 homolog, ceramide synthase 5

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q8N5B7 CERS5

Gene Names

CERS5, LASS5

Chain

chain:1-392

Reference Genes

BioGPS Gene:91012 CERS5

COSMIC (genes):CERS5 CERS5

CTD Gene:91012 CERS5

dbSNP Gene:91012 CERS5

ENSEMBL:ENSG00000139624 CERS5

HGNC:23749 CERS5

KEGG:hsa:91012 CERS5

Monarch:91012 CERS5

NCBI Gene:91012 CERS5

OMIM:615335 CERS5

UCSC:Q8N5B7 CERS5

Reference Transcript

Other Identifiers

11730217_a_at

11730218_s_at

11747619_a_at

16764535

224951_PM_at

224951_at

239491_PM_at

239491_at

3454295

3454297

3454298

3454299

3454300

3454303

3454304

3454305

3454306

3454307

3454308

3454309

3454310

3454311

3454312

3454313

3454314

3454315

3454316

3454317

3454318

3454319

3454320

3454321

3454322

3454323

3454329

3454330

49885_at

53053_at

7963174

91012

A_23_P76515

A_33_P3285038

GE87172

GO:0003677

GO:0005634

GO:0005783

GO:0005789

GO:0006629

GO:0006665

GO:0014003

GO:0016020

GO:0016740

GO:0030148

GO:0046513

GO:0048856

GO:0050291

HMNXSV003007898

HMNXSV003011722

Hs.101368.0.A1_3p_at

Hs.5331.0.S1_3p_at

ILMN_2208495

PH_hs_0026386

TC12001490.hg

TC12001491.hg

Participates

as a member of

Ceramide synthases [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

crsA [endoplasmic reticulum membrane] (Dictyostelium discoideum)

cers5 [endoplasmic reticulum membrane] (Danio rerio)

cers5 [endoplasmic reticulum membrane] (Xenopus tropicalis)

lac1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

CERS5 [endoplasmic reticulum membrane] (Bos taurus)

CERS5 [endoplasmic reticulum membrane] (Canis familiaris)

CERS5 [endoplasmic reticulum membrane] (Gallus gallus)

CERS5 [endoplasmic reticulum membrane] (Plasmodium falciparum)

CERS5 [endoplasmic reticulum membrane] (Sus scrofa)

LAG1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

schlank [endoplasmic reticulum membrane] (Drosophila melanogaster)

Cers5 [endoplasmic reticulum membrane] (Mus musculus)

Cers5 [endoplasmic reticulum membrane] (Rattus norvegicus)

Homologues of CERS5 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Homologues of CERS5 [endoplasmic reticulum membrane] (Plasmodium falciparum)

Homologues of CERS5 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Homologues of CERS5 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

hyl-2 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

hyl-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

LAC1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

lag1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_671723.1, NP_001268660.1

Guide to Pharmacology - Targets

2478

ENSEMBL

ENSP00000325485, ENST00000317551, ENSG00000139624, ENSP00000389050, ENST00000422340

OpenTargets

ENSG00000139624

IntEnz

2.3.1.291

GeneCards

CERS5

HPA

ENSG00000139624-CERS5

PRO

Q8N5B7

Pharos - Targets

Q8N5B7

GlyGen

Q8N5B7

HMDB Protein

HMDBP10978

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y639 NPTN	1	NPTN [plasma membrane] (R-HSA-8856422)	0.527	2
UniProt:Q16581 C3AR1	3	C3AR1 [plasma membrane] (R-HSA-444727) C3AR1 [specific granule membrane] (R-HSA-6799516) C3AR1 [azurophil granule membrane] (R-HSA-6799517)	0.527	2
UniProt:P51684 CCR6	1	CCR6 [plasma membrane] (R-HSA-373089)	0.527	2
UniProt:Q9H244 P2RY12	1	P2RY12 [plasma membrane] (R-HSA-391959)	0.527	2
UniProt:P25090 FPR2	4	FPR2 [plasma membrane] (R-HSA-416408) FPR2 [ficolin-1-rich granule membrane] (R-HSA-6803335) FPR2 [specific granule membrane] (R-HSA-6803319) FPR2 [tertiary granule membrane] (R-HSA-6803296)	0.527	2
UniProt:P61073 CXCR4	1	CXCR4 [plasma membrane] (R-HSA-2980772)	0.527	2
UniProt:Q9H8X2 IPPK	2	IPPK [cytosol] (R-HSA-1604598) IPPK [nucleoplasm] (R-HSA-2023949)	0.527	2

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